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Results: 1 to 20 of 77

Similar articles for PubMed (Select 23035050)

1.

Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness.

Moniz S, Martinho O, Pinto F, Sousa B, Loureiro C, Oliveira MJ, Moita LF, Honavar M, Pinheiro C, Pires M, Lopes JM, Jones C, Costello JF, Paredes J, Reis RM, Jordan P.

Hum Mol Genet. 2013 Jan 1;22(1):84-95. doi: 10.1093/hmg/dds405. Epub 2012 Oct 3.

2.

Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth.

Hong C, Moorefield KS, Jun P, Aldape KD, Kharbanda S, Phillips HS, Costello JF.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10974-9. Epub 2007 Jun 19.

3.

Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.

Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF.

Neuro Oncol. 2009 Aug;11(4):414-22. doi: 10.1215/15228517-2008-096. Epub 2008 Nov 11.

4.

WNK2 modulates MEK1 activity through the Rho GTPase pathway.

Moniz S, Matos P, Jordan P.

Cell Signal. 2008 Oct;20(10):1762-8. doi: 10.1016/j.cellsig.2008.06.002. Epub 2008 Jun 14.

PMID:
18593598
5.

Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development.

Dutruel C, Bergmann F, Rooman I, Zucknick M, Weichenhan D, Geiselhart L, Kaffenberger T, Rachakonda PS, Bauer A, Giese N, Hong C, Xie H, Costello JF, Hoheisel J, Kumar R, Rehli M, Schirmacher P, Werner J, Plass C, Popanda O, Schmezer P.

Oncogene. 2014 Jun 26;33(26):3401-10. doi: 10.1038/onc.2013.312. Epub 2013 Aug 5.

PMID:
23912455
6.

Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.

Moniz S, Veríssimo F, Matos P, Brazão R, Silva E, Kotelevets L, Chastre E, Gespach C, Jordan P.

Oncogene. 2007 Sep 6;26(41):6071-81. Epub 2007 Jul 30. Erratum in: Oncogene. 2008 Jan 3;27(1):155. Kotevelets, L [corrected to Kotelevets, L].

PMID:
17667937
7.

Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.

Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee WK, Cheng SY.

J Clin Invest. 2011 Dec;121(12):4670-84. doi: 10.1172/JCI58559. Epub 2011 Nov 14.

8.

SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation.

Lindemann C, Hackmann O, Delic S, Schmidt N, Reifenberger G, Riemenschneider MJ.

Acta Neuropathol. 2011 Aug;122(2):241-51. doi: 10.1007/s00401-011-0832-0. Epub 2011 May 18.

PMID:
21590492
9.

Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas.

Qiu J, Ai L, Ramachandran C, Yao B, Gopalakrishnan S, Fields CR, Delmas AL, Dyer LM, Melnick SJ, Yachnis AT, Schwartz PH, Fine HA, Brown KD, Robertson KD.

Lab Invest. 2008 Sep;88(9):910-25. doi: 10.1038/labinvest.2008.66. Epub 2008 Jul 7.

10.

Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes.

Senger DL, Tudan C, Guiot MC, Mazzoni IE, Molenkamp G, LeBlanc R, Antel J, Olivier A, Snipes GJ, Kaplan DR.

Cancer Res. 2002 Apr 1;62(7):2131-40.

11.

Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.

Konduri SD, Srivenugopal KS, Yanamandra N, Dinh DH, Olivero WC, Gujrati M, Foster DC, Kisiel W, Ali-Osman F, Kondraganti S, Lakka SS, Rao JS.

Oncogene. 2003 Jul 17;22(29):4509-16.

PMID:
12881707
12.

Changes of the O6-methylguanine-DNA methyltransferase promoter methylation and MGMT protein expression after adjuvant treatment in glioblastoma.

Jung TY, Jung S, Moon KS, Kim IY, Kang SS, Kim YH, Park CS, Lee KH.

Oncol Rep. 2010 May;23(5):1269-76.

PMID:
20372840
13.

Methylation-associated silencing of death-associated protein kinase gene in laryngeal squamous cell cancer.

Kong WJ, Zhang S, Guo C, Zhang S, Wang Y, Zhang D.

Laryngoscope. 2005 Aug;115(8):1395-401.

PMID:
16094112
14.

O6-Methylguanine-DNA methyltransferase is a novel negative effector of invasion in glioblastoma multiforme.

Chahal M, Abdulkarim B, Xu Y, Guiot MC, Easaw JC, Stifani N, Sabri S.

Mol Cancer Ther. 2012 Nov;11(11):2440-50. doi: 10.1158/1535-7163.MCT-11-0977. Epub 2012 Sep 17.

15.

Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma.

Tepel M, Roerig P, Wolter M, Gutmann DH, Perry A, Reifenberger G, Riemenschneider MJ.

Int J Cancer. 2008 Nov 1;123(9):2080-6. doi: 10.1002/ijc.23705.

PMID:
18709645
16.

The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Rutka F, Ennis M, McDonough WS, Berens ME, Symons M, Rutka JT.

Am J Pathol. 2008 Dec;173(6):1828-38. doi: 10.2353/ajpath.2008.080043. Epub 2008 Nov 13.

17.

Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas.

Costa AM, Pinto F, Martinho O, Oliveira MJ, Jordan P, Reis RM.

Oncotarget. 2015 Jan 30;6(3):1422-34.

18.

Ehd3, a regulator of vesicular trafficking, is silenced in gliomas and functions as a tumor suppressor by controlling cell cycle arrest and apoptosis.

Chukkapalli S, Amessou M, Dekhil H, Dilly AK, Liu Q, Bandyopadhyay S, Thomas RD, Bejna A, Batist G, Kandouz M.

Carcinogenesis. 2014 Apr;35(4):877-85. doi: 10.1093/carcin/bgt399. Epub 2013 Dec 4.

19.

MGMT expression and promoter methylation status may depend on the site of surgical sample collection within glioblastoma: a possible pitfall in stratification of patients?

Della Puppa A, Persano L, Masi G, Rampazzo E, Sinigaglia A, Pistollato F, Denaro L, Barzon L, Palù G, Basso G, Scienza R, d'Avella D.

J Neurooncol. 2012 Jan;106(1):33-41. doi: 10.1007/s11060-011-0639-9. Epub 2011 Jul 2.

PMID:
21725802
20.

Ephrin-B3 ligand promotes glioma invasion through activation of Rac1.

Nakada M, Drake KL, Nakada S, Niska JA, Berens ME.

Cancer Res. 2006 Sep 1;66(17):8492-500.

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