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Results: 1 to 20 of 107

1.

Dynamics and functional differences between dendroaspin and rhodostomin: insights into protein scaffolds in integrin recognition.

Cheng CH, Chen YC, Shiu JH, Chang YT, Chang YS, Huang CH, Chen CY, Chuang WJ.

Protein Sci. 2012 Dec;21(12):1872-84. doi: 10.1002/pro.2169. Epub 2012 Nov 6.

PMID:
23033223
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin alphaIIbbeta3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery.

Rahman S, Flynn G, Aitken A, Patel Y, Hussain F, Lu X, Loftus JC, French D, Wijelath E, Strand K, Savidge GF.

Biochem J. 2000 Feb 1;345 Pt 3:701-9.

PMID:
10642531
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Positional importance of Pro53 adjacent to the Arg49-Gly50-Asp51 sequence of rhodostomin in binding to integrin alphaIIbbeta3.

Chang CP, Chang JC, Chang HH, Tsai WJ, Lo SJ.

Biochem J. 2001 Jul 1;357(Pt 1):57-64.

PMID:
11415436
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Evaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion.

Lu X, Sun Y, Shang D, Wattam B, Egglezou S, Hughes T, Hyde E, Scully M, Kakkar V.

Biochem J. 2001 May 1;355(Pt 3):633-8.

PMID:
11311124
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: importance of the interactions between the D residue and integrin.

Chen CY, Shiu JH, Hsieh YH, Liu YC, Chen YC, Chen YC, Jeng WY, Tang MJ, Lo SJ, Chuang WJ.

Proteins. 2009 Sep;76(4):808-21. doi: 10.1002/prot.22387.

PMID:
19280603
[PubMed - indexed for MEDLINE]
9.

The effect of the single substitution of arginine within the RGD tripeptide motif of a modified neurotoxin dendroaspin on its activity of platelet aggregation and cell adhesion.

Lu X, Davies J, Lu D, Xia M, Wattam B, Shang D, Sun Y, Scully M, Kakkar V.

Cell Commun Adhes. 2006 May-Jun;13(3):171-83.

PMID:
16798616
[PubMed - indexed for MEDLINE]
10.

Arg-Tyr-Asp (RYD) and Arg-Cys-Asp (RCD) motifs in dendroaspin promote selective inhibition of beta1 and beta3 integrins.

Wattam B, Shang D, Rahman S, Egglezou S, Scully M, Kakkar V, Lu X.

Biochem J. 2001 May 15;356(Pt 1):11-7.

PMID:
11336631
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Effect of P to A mutation of the N-terminal residue adjacent to the Rgd motif on rhodostomin: importance of dynamics in integrin recognition.

Shiu JH, Chen CY, Chen YC, Chang YT, Chang YS, Huang CH, Chuang WJ.

PLoS One. 2012;7(1):e28833. doi: 10.1371/journal.pone.0028833. Epub 2012 Jan 4.

PMID:
22238583
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Integrin binding characteristics of the disintegrin-like domain of ADAM-15.

Lu D, Chung KF, Xia M, Lu X, Scully M, Kakkar V.

Thromb Haemost. 2006 Nov;96(5):642-51.

PMID:
17080222
[PubMed - indexed for MEDLINE]
13.

Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD.

Fujii Y, Okuda D, Fujimoto Z, Horii K, Morita T, Mizuno H.

J Mol Biol. 2003 Oct 3;332(5):1115-22.

PMID:
14499613
[PubMed - indexed for MEDLINE]
14.

The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization.

Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M, Nagaswami C, Weisel JW, McLane MA.

J Mol Biol. 2004 Oct 1;342(5):1625-36.

PMID:
15364586
[PubMed - indexed for MEDLINE]
15.
16.

Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin.

Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA.

Nat Struct Biol. 1994 Nov;1(11):802-7.

PMID:
7634091
[PubMed - indexed for MEDLINE]
17.

Modulation of integrin-binding selectivity by mutation within the RGD-loop of snake venom proteins: a novel drug development approach.

Lu X, Lu D, Scully MF, Kakkar VV.

Curr Med Chem Cardiovasc Hematol Agents. 2003 Jun;1(2):189-96. Review.

PMID:
15320698
[PubMed - indexed for MEDLINE]
18.

Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion.

Limam I, Bazaa A, Srairi-Abid N, Taboubi S, Jebali J, Zouari-Kessentini R, Kallech-Ziri O, Mejdoub H, Hammami A, El Ayeb M, Luis J, Marrakchi N.

Matrix Biol. 2010 Mar;29(2):117-26. doi: 10.1016/j.matbio.2009.09.009. Epub 2009 Oct 4.

PMID:
19808093
[PubMed - indexed for MEDLINE]
20.

Therapeutic integrin inhibition: allosteric and activation-specific inhibition strategies may surpass the initial ligand-mimetic strategies.

Ahrens I, Peter K.

Thromb Haemost. 2008 May;99(5):803-4. doi: 10.1160/TH08-03-0194. No abstract available.

PMID:
18449408
[PubMed - indexed for MEDLINE]

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