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Items: 1 to 20 of 156


Efficient TALEN-mediated gene knockout in livestock.

Carlson DF, Tan W, Lillico SG, Stverakova D, Proudfoot C, Christian M, Voytas DF, Long CR, Whitelaw CB, Fahrenkrug SC.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17382-7. doi: 10.1073/pnas.1211446109. Epub 2012 Oct 1.


Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs.

Xin J, Yang H, Fan N, Zhao B, Ouyang Z, Liu Z, Zhao Y, Li X, Song J, Yang Y, Zou Q, Yan Q, Zeng Y, Lai L.

PLoS One. 2013 Dec 17;8(12):e84250. doi: 10.1371/journal.pone.0084250. eCollection 2013.


Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation.

Ferguson C, McKay M, Harris RA, Homanics GE.

Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.


Transcription activator-like effector nucleases enable efficient plant genome engineering.

Zhang Y, Zhang F, Li X, Baller JA, Qi Y, Starker CG, Bogdanove AJ, Voytas DF.

Plant Physiol. 2013 Jan;161(1):20-7. doi: 10.1104/pp.112.205179. Epub 2012 Nov 2.


Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs).

Lei Y, Guo X, Liu Y, Cao Y, Deng Y, Chen X, Cheng CH, Dawid IB, Chen Y, Zhao H.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17484-9. doi: 10.1073/pnas.1215421109. Epub 2012 Oct 8.


Efficient nonmeiotic allele introgression in livestock using custom endonucleases.

Tan W, Carlson DF, Lancto CA, Garbe JR, Webster DA, Hackett PB, Fahrenkrug SC.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16526-31. doi: 10.1073/pnas.1310478110. Epub 2013 Sep 6.


Live pigs produced from genome edited zygotes.

Lillico SG, Proudfoot C, Carlson DF, Stverakova D, Neil C, Blain C, King TJ, Ritchie WA, Tan W, Mileham AJ, McLaren DG, Fahrenkrug SC, Whitelaw CB.

Sci Rep. 2013 Oct 10;3:2847. doi: 10.1038/srep02847.


High‑efficiency system for construction and evaluation of customized TALENs for silkworm genome editing.

Wang F, Ma S, Xu H, Duan J, Wang Y, Ding H, Liu Y, Wang X, Zhao P, Xia Q.

Mol Genet Genomics. 2013 Dec;288(12):683-90.


FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions.

Tokumasu D, Sakuma T, Hayashi Y, Hosoi S, Hiyama E, Yamamoto T.

Genes Cells. 2014 May;19(5):419-31. doi: 10.1111/gtc.12142. Epub 2014 Mar 18.


Inclusion of homologous DNA in nuclease-mediated gene targeting facilitates a higher incidence of bi-allelically modified cells.

Beaton BP, Kwon DN, Choi YJ, Kim JH, Samuel MS, Benne JA, Wells KD, Lee K, Kim JH, Prather RS.

Xenotransplantation. 2015 Sep-Oct;22(5):379-90. doi: 10.1111/xen.12194.


Myostatin knockout in bovine fetal fibroblasts by using TALEN.

Yang C, Tong H, Ma X, Du W, Liu D, Yang Y, Yan Y.

Yi Chuan. 2014 Jul;36(7):685-90. doi: 10.3724/SP.J.1005.2014.0685.


TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants.

Wendt T, Holm PB, Starker CG, Christian M, Voytas DF, Brinch-Pedersen H, Holme IB.

Plant Mol Biol. 2013 Oct;83(3):279-85. doi: 10.1007/s11103-013-0078-4. Epub 2013 May 21.


Comparison of TALEN scaffolds in Xenopus tropicalis.

Nakajima K, Yaoita Y.

Biol Open. 2013 Dec 15;2(12):1364-70. doi: 10.1242/bio.20136676.


Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases.

Hauschild J, Petersen B, Santiago Y, Queisser AL, Carnwath JW, Lucas-Hahn A, Zhang L, Meng X, Gregory PD, Schwinzer R, Cost GJ, Niemann H.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12013-7. doi: 10.1073/pnas.1106422108. Epub 2011 Jul 5. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):15010.


TALEN construction via "Unit Assembly" method and targeted genome modifications in zebrafish.

Huang P, Xiao A, Tong X, Zu Y, Wang Z, Zhang B.

Methods. 2014 Aug 15;69(1):67-75. doi: 10.1016/j.ymeth.2014.02.010. Epub 2014 Feb 18.


Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes.

Li C, Qi R, Singleterry R, Hyle J, Balch A, Li X, Sublett J, Berns H, Valentine M, Valentine V, Sherr CJ.

Mol Cell Biol. 2014 May;34(9):1649-58. doi: 10.1128/MCB.00023-14. Epub 2014 Feb 24.


Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering.

Liu J, Gaj T, Patterson JT, Sirk SJ, Barbas CF 3rd.

PLoS One. 2014 Jan 20;9(1):e85755. doi: 10.1371/journal.pone.0085755. eCollection 2014.


A library of TAL effector nucleases spanning the human genome.

Kim Y, Kweon J, Kim A, Chon JK, Yoo JY, Kim HJ, Kim S, Lee C, Jeong E, Chung E, Kim D, Lee MS, Go EM, Song HJ, Kim H, Cho N, Bang D, Kim S, Kim JS.

Nat Biotechnol. 2013 Mar;31(3):251-8. doi: 10.1038/nbt.2517. Epub 2013 Feb 17.


Multiplex genomic structure variation mediated by TALEN and ssODN.

Ma S, Wang X, Liu Y, Gao J, Zhang S, Shi R, Chang J, Zhao P, Xia Q.

BMC Genomics. 2014 Jan 18;15:41. doi: 10.1186/1471-2164-15-41.


Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM.

PLoS One. 2012;7(5):e37877. doi: 10.1371/journal.pone.0037877. Epub 2012 May 24.

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