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23027656,19660469,18218673,21620958,22461523,21486680,23455548,32086724,22112863,26299281,19592621,21604272,28678856,17204833,34713381,16670255,21859816,15173093,15380674,21168400,32607760,21406596,18950702,26822305,29653124,23158927,16698001,19450605,18031568,17916771,18360057,28710503,26054749,28295305,23664830,21278141,24522112,23631848,22426099,20963497,21553131,16413406,19699179,23153365,26796253,20883775,27084042,19850941,19286953,21565173,30831132,20522592,22527657,12728249,19895673,15486319,11494050,20705132,34401977,25766524,28159361,29229534,23279742,20518848,35258628,23519127,26515559,26617794,24632018,23250920,17562954,24037780,26254336,30936017,23751595,31116582,26606860,24231192,26527051,18070887,34623620,31356549,30009776,19103993,21321939,29179205,22232135,28608259,30063064,28617849,21858697,32339784,24902966,30007118,23338126,21937428,24249632,25955698,31918264,26939003,26828775,30535663,18775851,25169008,27342245,31545955,23000260,29297235,26299339,21829519,24554007,28965952,21601858,28261787,23210435,23788170,30735749,21427628,23429587,32671648,34524989,27565713,27973574,27505125,23519142,25475100,26631573,24526703,21948481,24211423,18632596,18845130,26476350,24464789,31488712,19890356,25759382,18948619,29752960,31618665,25270851,22441674,24817286,31228183,18332854,34587120,20943855,19390057,26989696,16651473,32746757,31026186,34301253,16424780,28495616,18952886,20503473,32185414,32673667,23640485,23329650,26837315,30223482,30315806,27902477,20930373,23340498,31093930,23568954,29766336,26884823,25758431,29704392,23999236,27498117,32457254,31266854,31774307,24632453,25665036,25283819,23483263,28098423,19135123,19850916,20004474,26746999,33438065,21938406,20830300,24214856,28245258,25736854,23738736,15792349,31225944,29107939,20382965,18291107,25226612,29715512,21833028,24648241,27912197,29494287,18162054,34364220,28320863,26160305,26526549,31104312,28766116,25628054,24391705,27956351,28865727,30629146,32500386,25386226,23911439,20811699,17508921,29921821,22237206,26906075,24441175,23733346,28483668,29913208,27034410,28986362,22154326,22203419,35209134,31014028,33199237,25997894,21618589,26873966,32524823,28423723,20433879,25896148,30835049,33808398,15799720,26245924,24275640,26571493,34369901,28544034,29141899,31833156,26515054,30576852,27487838,23104132,26577173,18483861,31511497,25515622,25973059,21911753,16735673,29655790,25600813,28946137,32361914,31217360,22956547,24812279,26440532,17651020,25358739,27467102,34477462,23546663,25203460,12439637,23871353,23285096,28947826,20035047,29660505,28554248,35758064,32186283,32509145,25037060,22294440,17339338,25499814,30159756,24594448,28471121,32652078,27233035,27501845,32170053,32468412,31636246,23864022,24072175,27435854,31866378,31445075,29609020,11884408,26675978,25345393,22864983,17545941,29566148,29627934,23296296,23453926,25711856,30636491,34311530,32283691,27167338,25766316,33140921,29688912,26838784,35930219,28643438,25858022,32007664,16013437,31355248,35088374,18756386,17588511,27097055,18234414,34898378,26507774,23724057,26374991,34233258,29794378,27476284,31002281,27802433,19942623,22160304,15703274,32752227,25560802,25617357,31058328,26318906,28609685,17875725,23161364,30810770,24326424,34047412,26420324,28608983,27338072,31957170,28574838,29236219,11027721,26045757,22989704,23965518,22679019,31229536,31034488,14739295,27194299,23297003,23135700,26648253,23246618,15124904,21628952,36562344,36309171,25841593,26132560,27537522,23012366,26230640,25446184,27315818,25305081,32860604,18652870,24839208,28937626,26158288,32075913,24704391,23704323,19261878,25556150,26981525,28428026,31163256,27589040,27357096,32068341,27048259,30843309,28038445,30472367,18451498,17904602,35438302,26007683,23249388,30003648,23678107,23288619,12869213,34313957,33000246,23461363,26833193,33388418,34105389,26089164,25967961,26082188,31741235,28237821,27574116,31054117,35088107,25896364,30734677,23360835,30347077,31004659,17854274,32802259,31434946,14588152,27297806,34562089,18852132,28802718,24914015,24120667,21976675,26573464,30029680,23988617,31881187,21150336,24270669,19700468,16301815,19625648,25300478,27222313,28857948,28971953,31995179,19328808,10952983,31871537,26772824,32879422,26502700,35863589,19038292,28315715,32124237,31210840,26862121,24291008,33583791,28099878,29207090,23190902,26297228,22562121,26838550,34530122,25529476,28960571,18156215,18843266,30558506,31389594,20495188,29054408,25657296,27243897,23521874,32034646,29880809,12505058,30423020,30013448,24727461,25758465,29968904,36834585,30525890,26899469,30596969,28260045,21232037,24121045,32317318,29133306,20862515,16269455,17101790,28807058,25448438,21814770,35171536,16251354,25514037,23628005,19358873,22001402,28683591,29846769,31083537,31773441,32780664,28484120,23338613,28837153,27138844,25539628,25725130,12038964,26756900,21303748,22619697,16565313,19033667,19299643,29363851,27816693,16521128,28230797,19470639,27106802,33737606,32624698,24506563,25552354,30728290,32016695,28760703,25370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Results by year

Year	Number of Results
1975	2
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1,163 results

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Page 1

Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways.

Ma J, Wang Y, Zheng D, Wei M, Xu H, Peng T. Ma J, et al. Cardiovasc Res. 2013 Jan 1;97(1):77-87. doi: 10.1093/cvr/cvs309. Epub 2012 Oct 1. Cardiovasc Res. 2013. PMID: 23027656

Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity.

Yoshida M, Shiojima I, Ikeda H, Komuro I. Yoshida M, et al. J Mol Cell Cardiol. 2009 Nov;47(5):698-705. doi: 10.1016/j.yjmcc.2009.07.024. Epub 2009 Aug 3. J Mol Cell Cardiol. 2009. PMID: 19660469

TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species.

Jin S, Ray RM, Johnson LR. Jin S, et al. Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G928-37. doi: 10.1152/ajpgi.00219.2007. Epub 2008 Jan 24. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18218673 Free article.

β1-Integrin is up-regulated via Rac1-dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response.

Häuselmann SP, Rosc-Schlüter BI, Lorenz V, Plaisance I, Brink M, Pfister O, Kuster GM. Häuselmann SP, et al. Free Radic Biol Med. 2011 Aug 1;51(3):609-18. doi: 10.1016/j.freeradbiomed.2011.05.007. Epub 2011 May 14. Free Radic Biol Med. 2011. PMID: 21620958

Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress.

Gratia S, Kay L, Potenza L, Seffouh A, Novel-Chaté V, Schnebelen C, Sestili P, Schlattner U, Tokarska-Schlattner M. Gratia S, et al. Cardiovasc Res. 2012 Aug 1;95(3):290-9. doi: 10.1093/cvr/cvs134. Epub 2012 Mar 28. Cardiovasc Res. 2012. PMID: 22461523

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis.

Ghosh J, Das J, Manna P, Sil PC. Ghosh J, et al. Biomaterials. 2011 Jul;32(21):4857-66. doi: 10.1016/j.biomaterials.2011.03.048. Epub 2011 Apr 12. Biomaterials. 2011. PMID: 21486680

Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin.

Wang Y, Zheng D, Wei M, Ma J, Yu Y, Chen R, Lacefield JC, Xu H, Peng T. Wang Y, et al. Cardiovasc Res. 2013 Jun 1;98(3):381-90. doi: 10.1093/cvr/cvt048. Epub 2013 Mar 1. Cardiovasc Res. 2013. PMID: 23455548

Human Amnion Membrane Proteins Prevent Doxorubicin-Induced Oxidative Stress Injury and Apoptosis in Rat H9c2 Cardiomyocytes.

Faridvand Y, Haddadi P, Vahedian V, Nozari S, Nejabati HR, Pezeshkian M, Afrasiabi A, Safaie N, Jodati A, Nouri M. Faridvand Y, et al. Cardiovasc Toxicol. 2020 Aug;20(4):370-379. doi: 10.1007/s12012-020-09564-8. Cardiovasc Toxicol. 2020. PMID: 32086724

The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage.

Wang H, Zhou W, Zheng Z, Zhang P, Tu B, He Q, Zhu WG. Wang H, et al. DNA Repair (Amst). 2012 Feb 1;11(2):146-56. doi: 10.1016/j.dnarep.2011.10.014. Epub 2011 Nov 23. DNA Repair (Amst). 2012. PMID: 22112863

Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting reactive oxygen species-activated extracellular signal-regulated kinase 1/2 in H9c2 cardiac myocytes.

Liu MH, Lin XL, Zhang Y, He J, Tan TP, Wu SJ, Liu J, Tian W, Chen L, Yu S, Li J, Yuan C. Liu MH, et al. Mol Med Rep. 2015 Nov;12(5):6841-8. doi: 10.3892/mmr.2015.4234. Epub 2015 Aug 21. Mol Med Rep. 2015. PMID: 26299281

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