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Results: 1 to 20 of 90

1.

Medicine. Drug trial offers uncertain start in race to save children with progeria.

Couzin-Frankel J.

Science. 2012 Sep 28;337(6102):1594-5. No abstract available.

PMID:
23019622
[PubMed - indexed for MEDLINE]
2.

Medicine. Mouse study suggests cancer drugs could help prematurely aging kids.

Travis J.

Science. 2006 Feb 17;311(5763):934-5. No abstract available.

PMID:
16484462
[PubMed - indexed for MEDLINE]
3.

Drug development for progeria yields insights into normal aging.

Jiang K.

Nat Med. 2013 May;19(5):515. doi: 10.1038/nm0513-515. No abstract available.

PMID:
23652088
[PubMed - indexed for MEDLINE]
4.

Progeria, the nucleolus and farnesyltransferase inhibitors.

Mehta IS, Bridger JM, Kill IR.

Biochem Soc Trans. 2010 Feb;38(Pt 1):287-91. doi: 10.1042/BST0380287.

PMID:
20074076
[PubMed - indexed for MEDLINE]
5.

New approaches to progeria.

Kieran MW, Gordon L, Kleinman M.

Pediatrics. 2007 Oct;120(4):834-41. Review. Erratum in: Pediatrics. 2007 Dec;120(6):1405.

PMID:
17908771
[PubMed - indexed for MEDLINE]
Free Article
6.

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome.

Gordon LB, Kleinman ME, Miller DT, Neuberg DS, Giobbie-Hurder A, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland R, Snyder BD, Fligor B, Bishop WR, Statkevich P, Regen A, Sonis A, Riley S, Ploski C, Correia A, Quinn N, Ullrich NJ, Nazarian A, Liang MG, Huh SY, Schwartzman A, Kieran MW.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16666-71. doi: 10.1073/pnas.1202529109. Epub 2012 Sep 24.

PMID:
23012407
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Lamin A-linked progerias: is farnesylation the be all and end all?

Smallwood DT, Shackleton S.

Biochem Soc Trans. 2010 Feb;38(Pt 1):281-6. doi: 10.1042/BST0380281.

PMID:
20074075
[PubMed - indexed for MEDLINE]
8.

Lonafarnib for cancer and progeria.

Wong NS, Morse MA.

Expert Opin Investig Drugs. 2012 Jul;21(7):1043-55. doi: 10.1517/13543784.2012.688950. Epub 2012 May 24. Review.

PMID:
22620979
[PubMed - indexed for MEDLINE]
9.

Targeting protein prenylation in progeria.

Young SG, Yang SH, Davies BS, Jung HJ, Fong LG.

Sci Transl Med. 2013 Feb 6;5(171):171ps3. doi: 10.1126/scitranslmed.3005229. Review.

PMID:
23390246
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, Majumdar S, Bergo MO, Young SG, Fong LG.

J Clin Invest. 2006 Aug;116(8):2115-21.

PMID:
16862216
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders.

Barrowman J, Michaelis S.

Biol Chem. 2009 Aug;390(8):761-73. doi: 10.1515/BC.2009.080. Review.

PMID:
19453269
[PubMed - indexed for MEDLINE]
12.

Highlights of the 2007 Progeria Research Foundation scientific workshop: progress in translational science.

Gordon LB, Harling-Berg CJ, Rothman FG.

J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):777-87. No abstract available.

PMID:
18772465
[PubMed - indexed for MEDLINE]
13.

Gene discovery speeds progeria research.

Kuehn BM.

JAMA. 2006 Feb 22;295(8):876-8. No abstract available.

PMID:
16493093
[PubMed - indexed for MEDLINE]
14.

Protein farnesyltransferase inhibitors and progeria.

Meta M, Yang SH, Bergo MO, Fong LG, Young SG.

Trends Mol Med. 2006 Oct;12(10):480-7. Epub 2006 Aug 30. Review.

PMID:
16942914
[PubMed - indexed for MEDLINE]
15.

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.

Glynn MW, Glover TW.

Hum Mol Genet. 2005 Oct 15;14(20):2959-69. Epub 2005 Aug 26.

PMID:
16126733
[PubMed - indexed for MEDLINE]
Free Article
16.

Moving from gene discovery to clinical trials in Hutchinson-Gilford progeria syndrome.

King AA, Heyer GL.

Neurology. 2013 Jul 30;81(5):408-9. doi: 10.1212/WNL.0b013e31829d87cd. Epub 2013 Jun 28. No abstract available.

PMID:
23897868
[PubMed - indexed for MEDLINE]
17.

New cures sought from old drugs.

Wadman M.

Nature. 2012 Oct 4;490(7418):15. doi: 10.1038/490015a. No abstract available.

PMID:
23038441
[PubMed - indexed for MEDLINE]
18.

Farnesyltransferase inihibitors in hematologic malignancies.

Harousseau JL.

Blood Rev. 2007 Jul;21(4):173-82. Epub 2007 Feb 12. Review.

PMID:
17293017
[PubMed - indexed for MEDLINE]
19.

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG.

Science. 2006 Mar 17;311(5767):1621-3. Epub 2006 Feb 16.

PMID:
16484451
[PubMed - indexed for MEDLINE]
Free Article
20.

Farnesyl protein transferase inhibition: a novel approach to anti-tumor therapy. the discovery and development of SCH 66336.

Ganguly AK, Doll RJ, Girijavallabhan VM.

Curr Med Chem. 2001 Oct;8(12):1419-36. Review.

PMID:
11562275
[PubMed - indexed for MEDLINE]

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