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Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype.

Camerino C, Zayzafoon M, Rymaszewski M, Heiny J, Rios M, Hauschka PV.

Endocrinology. 2012 Nov;153(11):5394-405. doi: 10.1210/en.2012-1378. Epub 2012 Sep 25.


Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue.

Narvaez CJ, Matthews D, Broun E, Chan M, Welsh J.

Endocrinology. 2009 Feb;150(2):651-61. doi: 10.1210/en.2008-1118. Epub 2008 Oct 9.


Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice.

Fox EA, Biddinger JE, Jones KR, McAdams J, Worman A.

Neuroscience. 2013 Jan 15;229:176-99. doi: 10.1016/j.neuroscience.2012.09.078. Epub 2012 Oct 13.


White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis.

Cao L, Choi EY, Liu X, Martin A, Wang C, Xu X, During MJ.

Cell Metab. 2011 Sep 7;14(3):324-38. doi: 10.1016/j.cmet.2011.06.020.


Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome.

Burns B, Schmidt K, Williams SR, Kim S, Girirajan S, Elsea SH.

Hum Mol Genet. 2010 Oct 15;19(20):4026-42. doi: 10.1093/hmg/ddq317. Epub 2010 Jul 27.


Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice.

Tsuchida A, Nonomura T, Ono-Kishino M, Nakagawa T, Taiji M, Noguchi H.

Int J Obes Relat Metab Disord. 2001 Sep;25(9):1286-93.


Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate.

Wang C, Bomberg E, Billington C, Levine A, Kotz CM.

Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R992-1002. Epub 2007 Jun 13.


Effects of risperidone on energy balance in female C57BL/6J mice.

Li X, Johnson MS, Smith DL Jr, Li Y, Kesterson RA, Allison DB, Nagy TR.

Obesity (Silver Spring). 2013 Sep;21(9):1850-7. doi: 10.1002/oby.20350. Epub 2013 May 29.


Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure.

Wang C, Bomberg E, Billington CJ, Levine AS, Kotz CM.

Brain Res. 2010 Jun 8;1336:66-77. doi: 10.1016/j.brainres.2010.04.013. Epub 2010 Apr 14.


Conjugated linoleic acid induces uncoupling protein 1 in white adipose tissue of ob/ob mice.

Wendel AA, Purushotham A, Liu LF, Belury MA.

Lipids. 2009 Nov;44(11):975-82. doi: 10.1007/s11745-009-3348-9. Epub 2009 Sep 25.


Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity.

Uçeyler N, Schütt M, Palm F, Vogel C, Meier M, Schmitt A, Lesch KP, Mössner R, Sommer C.

Int J Obes (Lond). 2010 Apr;34(4):701-11. doi: 10.1038/ijo.2009.289. Epub 2010 Jan 19.


Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.

Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF.

Nat Neurosci. 2003 Jul;6(7):736-42.


Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice.

Sha H, Xu J, Tang J, Ding J, Gong J, Ge X, Kong D, Gao X.

Physiol Genomics. 2007 Oct 22;31(2):252-63. Epub 2007 Jul 24.


Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.

Lau P, Tuong ZK, Wang SC, Fitzsimmons RL, Goode JM, Thomas GP, Cowin GJ, Pearen MA, Mardon K, Stow JL, Muscat GE.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E159-71. doi: 10.1152/ajpendo.00056.2014. Epub 2014 Nov 25.


Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.

Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst EM, Keijer J, Klaus S.

Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E469-82. doi: 10.1152/ajpendo.00330.2013. Epub 2013 Dec 17.


Control of hyperphagia prevents obesity in BDNF heterozygous mice.

Coppola V, Tessarollo L.

Neuroreport. 2004 Dec 3;15(17):2665-8.


Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity.

Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M.

J Neurosci. 2007 Dec 26;27(52):14265-74.


FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes.

Tews D, Fischer-Posovszky P, Fromme T, Klingenspor M, Fischer J, Rüther U, Marienfeld R, Barth TF, Möller P, Debatin KM, Wabitsch M.

Endocrinology. 2013 Sep;154(9):3141-51. doi: 10.1210/en.2012-1873. Epub 2013 Jun 10.

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