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1.

In vitro scan for enhancers at the TCF7L2 locus.

Savic D, Park SY, Bailey KA, Bell GI, Nobrega MA.

Diabetologia. 2013 Jan;56(1):121-5. doi: 10.1007/s00125-012-2730-y. Epub 2012 Sep 26.

2.

An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers.

Savic D, Bell GI, Nobrega MA.

PLoS One. 2012;7(5):e36501. doi: 10.1371/journal.pone.0036501. Epub 2012 May 10.

3.

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.

Savic D, Ye H, Aneas I, Park SY, Bell GI, Nobrega MA.

Genome Res. 2011 Sep;21(9):1417-25. doi: 10.1101/gr.123745.111. Epub 2011 Jun 14.

4.

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.

Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL.

Am J Hum Genet. 2014 Feb 6;94(2):186-97. doi: 10.1016/j.ajhg.2013.12.011. Epub 2014 Jan 16.

5.

Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.

Pang DX, Smith AJ, Humphries SE.

Nutr Metab Cardiovasc Dis. 2013 Jun;23(6):550-6. doi: 10.1016/j.numecd.2011.12.012. Epub 2012 Mar 7.

6.

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.

Parker SC, Stitzel ML, Taylor DL, Orozco JM, Erdos MR, Akiyama JA, van Bueren KL, Chines PS, Narisu N; NISC Comparative Sequencing Program, Black BL, Visel A, Pennacchio LA, Collins FS; National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program Authors; NISC Comparative Sequencing Program Authors.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17921-6. doi: 10.1073/pnas.1317023110. Epub 2013 Oct 14.

7.

TCF7L2 is a master regulator of insulin production and processing.

Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O.

Hum Mol Genet. 2014 Dec 15;23(24):6419-31. doi: 10.1093/hmg/ddu359. Epub 2014 Jul 11.

8.

Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.

Xia Q, Deliard S, Yuan CX, Johnson ME, Grant SF.

Eur J Hum Genet. 2015 Jan;23(1):103-9. doi: 10.1038/ejhg.2014.48. Epub 2014 Mar 26.

PMID:
24667787
9.

Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus.

Fogarty MP, Panhuis TM, Vadlamudi S, Buchkovich ML, Mohlke KL.

Diabetes. 2013 May;62(5):1756-62. doi: 10.2337/db12-0972. Epub 2013 Jan 17.

10.

Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.

Palmer ND, Hester JM, An SS, Adeyemo A, Rotimi C, Langefeld CD, Freedman BI, Ng MC, Bowden DW.

Diabetes. 2011 Feb;60(2):662-8. doi: 10.2337/db10-0134. Epub 2010 Oct 27.

11.

Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.

Ng MC, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen YD, Bertoni AG, Li M, Grant SF, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD, Freedman BI, Rotter JI, Wilson JG, Bowden DW.

Diabetes. 2013 Mar;62(3):965-76. doi: 10.2337/db12-0266. Epub 2012 Nov 27.

12.

Redundant enhancers and causal variants in the TCF7L2 gene.

Ruiz-Narváez EA.

Eur J Hum Genet. 2014 Nov;22(11):1243-6. doi: 10.1038/ejhg.2014.17. Epub 2014 Feb 12. No abstract available.

PMID:
24518834
13.

A map of open chromatin in human pancreatic islets.

Gaulton KJ, Nammo T, Pasquali L, Simon JM, Giresi PG, Fogarty MP, Panhuis TM, Mieczkowski P, Secchi A, Bosco D, Berney T, Montanya E, Mohlke KL, Lieb JD, Ferrer J.

Nat Genet. 2010 Mar;42(3):255-9. doi: 10.1038/ng.530. Epub 2010 Jan 31.

14.

Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects.

Barra GB, Dutra LA, Watanabe SC, Costa PG, Cruz PS, Azevedo MF, Amato AA.

Arq Bras Endocrinol Metabol. 2012 Nov;56(8):479-84.

15.

On the identification of potential regulatory variants within genome wide association candidate SNP sets.

Chen CY, Chang IS, Hsiung CA, Wasserman WW.

BMC Med Genomics. 2014 Jun 11;7:34. doi: 10.1186/1755-8794-7-34.

16.

Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.

Zhou Y, Zhang E, Berggreen C, Jing X, Osmark P, Lang S, Cilio CM, Göransson O, Groop L, Renström E, Hansson O.

Hum Mol Genet. 2012 Jan 1;21(1):196-207. doi: 10.1093/hmg/ddr454. Epub 2011 Sep 30.

17.

Stronger association of common variants in TCF7L2 gene with nonobese type 2 diabetes in the Latvian population.

Kalnina I, Geldnere K, Tarasova L, Nikitina-Zake L, Peculis R, Fridmanis D, Pirags V, Klovins J.

Exp Clin Endocrinol Diabetes. 2012 Sep;120(8):466-8. doi: 10.1055/s-0032-1306298. Epub 2012 Mar 22.

PMID:
22441719
18.

Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus.

Greenawalt DM, Sieberts SK, Cornelis MC, Girman CJ, Zhong H, Yang X, Guinney J, Qi L, Hu FB.

Am J Epidemiol. 2012 Sep 1;176(5):423-30. doi: 10.1093/aje/kws123. Epub 2012 Aug 2.

19.

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response.

Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu XD, Topol EJ, Rosenfeld MG, Frazer KA.

Nature. 2011 Feb 10;470(7333):264-8. doi: 10.1038/nature09753.

20.

Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population.

Ereqat S, Nasereddin A, Cauchi S, Azmi K, Abdeen Z, Amin R.

Acta Diabetol. 2010 Dec;47 Suppl 1:195-8. doi: 10.1007/s00592-009-0161-0. Epub 2009 Nov 3.

PMID:
19885641
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