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Results: 1 to 20 of 70

1.

Correlating conformational shift induction with altered inhibitor potency in a multidrug resistant HIV-1 protease variant.

de Vera IM, Blackburn ME, Fanucci GE.

Biochemistry. 2012 Oct 9;51(40):7813-5. doi: 10.1021/bi301010z. Epub 2012 Sep 28.

PMID:
23009326
[PubMed - indexed for MEDLINE]
2.

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.

Yedidi RS, Muhuhi JM, Liu Z, Bencze KZ, Koupparis K, O'Connor CE, Kovari IA, Spaller MR, Kovari LC.

Biochem Biophys Res Commun. 2013 Sep 6;438(4):703-8. doi: 10.1016/j.bbrc.2013.07.117. Epub 2013 Aug 3.

PMID:
23921229
[PubMed - indexed for MEDLINE]
3.

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.

Yedidi RS, Proteasa G, Martinez JL, Vickrey JF, Martin PD, Wawrzak Z, Liu Z, Kovari IA, Kovari LC.

Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):524-32. doi: 10.1107/S0907444911011541. Epub 2011 May 17.

PMID:
21636892
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Elucidating a relationship between conformational sampling and drug resistance in HIV-1 protease.

de Vera IM, Smith AN, Dancel MC, Huang X, Dunn BM, Fanucci GE.

Biochemistry. 2013 May 14;52(19):3278-88. doi: 10.1021/bi400109d. Epub 2013 May 1.

PMID:
23566104
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Nine crystal structures determine the substrate envelope of the MDR HIV-1 protease.

Liu Z, Wang Y, Brunzelle J, Kovari IA, Kovari LC.

Protein J. 2011 Mar;30(3):173-83. doi: 10.1007/s10930-011-9316-2.

PMID:
21394574
[PubMed - indexed for MEDLINE]
6.

Adaptive inhibitors of the HIV-1 protease.

Ohtaka H, Freire E.

Prog Biophys Mol Biol. 2005 Jun;88(2):193-208. Review.

PMID:
15572155
[PubMed - indexed for MEDLINE]
7.

Monitoring inhibitor-induced conformational population shifts in HIV-1 protease by pulsed EPR spectroscopy.

Blackburn ME, Veloro AM, Fanucci GE.

Biochemistry. 2009 Sep 22;48(37):8765-7. doi: 10.1021/bi901201q.

PMID:
19691291
[PubMed - indexed for MEDLINE]
8.

Molecular dynamics studies on HIV-1 protease: a comparison of the flap motions between wild type protease and the M46I/G51D double mutant.

Lauria A, Ippolito M, Almerico AM.

J Mol Model. 2007 Nov;13(11):1151-6. Epub 2007 Sep 6.

PMID:
17786489
[PubMed - indexed for MEDLINE]
9.

Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes.

Velazquez-Campoy A, Vega S, Freire E.

Biochemistry. 2002 Jul 9;41(27):8613-9.

PMID:
12093278
[PubMed - indexed for MEDLINE]
10.

Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.

Mahalingam B, Louis JM, Hung J, Harrison RW, Weber IT.

Proteins. 2001 Jun 1;43(4):455-64.

PMID:
11340661
[PubMed - indexed for MEDLINE]
11.

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.

Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC.

Structure. 2005 Dec;13(12):1887-95.

PMID:
16338417
[PubMed - indexed for MEDLINE]
Free Article
12.

Accurate ensemble molecular dynamics binding free energy ranking of multidrug-resistant HIV-1 proteases.

Sadiq SK, Wright DW, Kenway OA, Coveney PV.

J Chem Inf Model. 2010 May 24;50(5):890-905. doi: 10.1021/ci100007w.

PMID:
20384328
[PubMed - indexed for MEDLINE]
13.

The folding free-energy surface of HIV-1 protease: insights into the thermodynamic basis for resistance to inhibitors.

Noel AF, Bilsel O, Kundu A, Wu Y, Zitzewitz JA, Matthews CR.

J Mol Biol. 2009 Apr 10;387(4):1002-16. doi: 10.1016/j.jmb.2008.12.061. Epub 2009 Jan 6.

PMID:
19150359
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Drug pressure selected mutations in HIV-1 protease alter flap conformations.

Galiano L, Ding F, Veloro AM, Blackburn ME, Simmerling C, Fanucci GE.

J Am Chem Soc. 2009 Jan 21;131(2):430-1. doi: 10.1021/ja807531v.

PMID:
19140783
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance.

Hong L, Zhang XC, Hartsuck JA, Tang J.

Protein Sci. 2000 Oct;9(10):1898-904.

PMID:
11106162
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations.

Wallqvist A, Smythers GW, Covell DG.

Protein Eng. 1998 Nov;11(11):999-1005.

PMID:
9876920
[PubMed - indexed for MEDLINE]
Free Article
17.

A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A.

Smidt ML, Potts KE, Tucker SP, Blystone L, Stiebel TR Jr, Stallings WC, McDonald JJ, Pillay D, Richman DD, Bryant ML.

Antimicrob Agents Chemother. 1997 Mar;41(3):515-22.

PMID:
9055985
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Multidrug resistance to HIV-1 protease inhibition requires cooperative coupling between distal mutations.

Ohtaka H, Schön A, Freire E.

Biochemistry. 2003 Nov 25;42(46):13659-66.

PMID:
14622012
[PubMed - indexed for MEDLINE]
19.

Solution structure of HIV-1 protease flaps probed by comparison of molecular dynamics simulation ensembles and EPR experiments.

Ding F, Layten M, Simmerling C.

J Am Chem Soc. 2008 Jun 11;130(23):7184-5. doi: 10.1021/ja800893d. Epub 2008 May 15.

PMID:
18479129
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease.

Weikl TR, Hemmateenejad B.

Biochim Biophys Acta. 2013 May;1834(5):867-73. doi: 10.1016/j.bbapap.2013.01.027. Epub 2013 Feb 1.

PMID:
23376188
[PubMed - indexed for MEDLINE]
Free Article

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