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Results: 1 to 20 of 126

1.

Inhibition of cell proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1.

Mazzone A, Eisenman ST, Strege PR, Yao Z, Ordog T, Gibbons SJ, Farrugia G.

Biochem Biophys Res Commun. 2012 Oct 19;427(2):248-53. doi: 10.1016/j.bbrc.2012.09.022. Epub 2012 Sep 17.

PMID:
22995309
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01.

Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA.

Br J Pharmacol. 2013 Feb;168(3):773-84. doi: 10.1111/j.1476-5381.2012.02199.x.

PMID:
22946562
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Ano1 as a regulator of proliferation.

Stanich JE, Gibbons SJ, Eisenman ST, Bardsley MR, Rock JR, Harfe BD, Ordog T, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2011 Dec;301(6):G1044-51. doi: 10.1152/ajpgi.00196.2011. Epub 2011 Sep 22.

PMID:
21940901
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.

Gomez-Pinilla PJ, Gibbons SJ, Bardsley MR, Lorincz A, Pozo MJ, Pasricha PJ, Van de Rijn M, West RB, Sarr MG, Kendrick ML, Cima RR, Dozois EJ, Larson DW, Ordog T, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1370-81. doi: 10.1152/ajpgi.00074.2009. Epub 2009 Apr 16.

PMID:
19372102
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics.

Bill A, Hall ML, Borawski J, Hodgson C, Jenkins J, Piechon P, Popa O, Rothwell C, Tranter P, Tria S, Wagner T, Whitehead L, Gaither LA.

J Biol Chem. 2014 Apr 18;289(16):11029-41. doi: 10.1074/jbc.M114.549188. Epub 2014 Mar 5.

PMID:
24599954
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity.

Zhu MH, Kim TW, Ro S, Yan W, Ward SM, Koh SD, Sanders KM.

J Physiol. 2009 Oct 15;587(Pt 20):4905-18. doi: 10.1113/jphysiol.2009.176206. Epub 2009 Aug 24.

PMID:
19703958
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles.

Hwang SJ, Blair PJ, Britton FC, O'Driscoll KE, Hennig G, Bayguinov YR, Rock JR, Harfe BD, Sanders KM, Ward SM.

J Physiol. 2009 Oct 15;587(Pt 20):4887-904. doi: 10.1113/jphysiol.2009.176198. Epub 2009 Aug 17.

PMID:
19687122
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Anoctamins and gastrointestinal smooth muscle excitability.

Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM.

Exp Physiol. 2012 Feb;97(2):200-6. doi: 10.1113/expphysiol.2011.058248. Epub 2011 Oct 14. Review.

PMID:
22002868
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.

Namkung W, Phuan PW, Verkman AS.

J Biol Chem. 2011 Jan 21;286(3):2365-74. doi: 10.1074/jbc.M110.175109. Epub 2010 Nov 17.

PMID:
21084298
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Computational modeling of anoctamin 1 calcium-activated chloride channels as pacemaker channels in interstitial cells of Cajal.

Lees-Green R, Gibbons SJ, Farrugia G, Sneyd J, Cheng LK.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15;306(8):G711-27. doi: 10.1152/ajpgi.00449.2013. Epub 2014 Jan 30.

PMID:
24481603
[PubMed - indexed for MEDLINE]
11.

Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma.

Liu W, Lu M, Liu B, Huang Y, Wang K.

Cancer Lett. 2012 Dec 29;326(1):41-51. doi: 10.1016/j.canlet.2012.07.015. Epub 2012 Jul 20.

PMID:
22820160
[PubMed - indexed for MEDLINE]
12.

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.

Forrest AS, Joyce TC, Huebner ML, Ayon RJ, Wiwchar M, Joyce J, Freitas N, Davis AJ, Ye L, Duan DD, Singer CA, Valencik ML, Greenwood IA, Leblanc N.

Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1229-43. doi: 10.1152/ajpcell.00044.2012. Epub 2012 Oct 3.

PMID:
23034390
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation.

Kashyap P, Gomez-Pinilla PJ, Pozo MJ, Cima RR, Dozois EJ, Larson DW, Ordog T, Gibbons SJ, Farrugia G.

Neurogastroenterol Motil. 2011 Aug;23(8):760-5. doi: 10.1111/j.1365-2982.2011.01729.x. Epub 2011 May 17.

PMID:
21585622
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Altered expression of Ano1 variants in human diabetic gastroparesis.

Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Rae JL, Parkman HP, Linden DR, Szurszewski JH, Ördög T, Gibbons SJ, Farrugia G.

J Biol Chem. 2011 Apr 15;286(15):13393-403. doi: 10.1074/jbc.M110.196089. Epub 2011 Feb 24.

PMID:
21349842
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis.

Iqbal J, Tonta MA, Mitsui R, Li Q, Kett M, Li J, Parkington HC, Hashitani H, Lang RJ.

Br J Pharmacol. 2012 Apr;165(7):2389-408. doi: 10.1111/j.1476-5381.2011.01730.x.

PMID:
22014103
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The multiple expression of Ca²⁺-activated Cl⁻ channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein.

Ohshiro J, Yamamura H, Saeki T, Suzuki Y, Imaizumi Y.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):518-23. doi: 10.1016/j.bbrc.2013.11.117. Epub 2013 Dec 7.

PMID:
24321548
[PubMed - indexed for MEDLINE]
17.

Bradykinin modulates pacemaker currents through bradykinin B2 receptors in cultured interstitial cells of Cajal from the murine small intestine.

Choi S, Park do Y, Yeum CH, Chang IY, You HJ, Park CG, Kim MY, Kong ID, So I, Kim KW, Jun JY.

Br J Pharmacol. 2006 Aug;148(7):918-26. Epub 2006 Jun 19.

PMID:
16783409
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Differential expression of ionic conductances in interstitial cells of Cajal in the murine gastric antrum.

Takeda Y, Koh SD, Sanders KM, Ward SM.

J Physiol. 2008 Feb 1;586(3):859-73. Epub 2007 Nov 22.

PMID:
18033817
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Spontaneous electrical rhythmicity in cultured interstitial cells of cajal from the murine small intestine.

Koh SD, Sanders KM, Ward SM.

J Physiol. 1998 Nov 15;513 ( Pt 1):203-13.

PMID:
9782170
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.

Namkung W, Yao Z, Finkbeiner WE, Verkman AS.

FASEB J. 2011 Nov;25(11):4048-62. doi: 10.1096/fj.11-191627. Epub 2011 Aug 11.

PMID:
21836025
[PubMed - indexed for MEDLINE]
Free PMC Article

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