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Results: 1 to 20 of 145

Similar articles for PubMed (Select 22995073)

1.

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.

Argiriadi MA, Goedken ER, Banach D, Borhani DW, Burchat A, Dixon RW, Marcotte D, Overmeyer G, Pivorunas V, Sadhukhan R, Sousa S, Moore NS, Tomlinson M, Voss J, Wang L, Wishart N, Woller K, Talanian RV.

BMC Struct Biol. 2012 Sep 20;12:22. doi: 10.1186/1472-6807-12-22.

2.

Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study.

Argiriadi MA, Sousa S, Banach D, Marcotte D, Xiang T, Tomlinson MJ, Demers M, Harris C, Kwak S, Hardman J, Pietras M, Quinn L, DiMauro J, Ni B, Mankovich J, Borhani DW, Talanian RV, Sadhukhan R.

BMC Struct Biol. 2009 Mar 18;9:16. doi: 10.1186/1472-6807-9-16.

3.

Design of a peptide inhibitor of tyrosine kinase 2.

Works MG, Song B, Kibler P, Tanga MJ, Galande AK, D'Andrea A.

Protein Pept Lett. 2014 May;21(5):419-25.

PMID:
24304386
4.
5.

Lead identification of novel and selective TYK2 inhibitors.

Liang J, Tsui V, Van Abbema A, Bao L, Barrett K, Beresini M, Berezhkovskiy L, Blair WS, Chang C, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liimatta M, Mantik P, Menghrajani K, Murray J, Sambrone A, Xiao Y, Shia S, Shin Y, Smith J, Sohn S, Stanley M, Ultsch M, Zhang B, Wu LC, Magnuson S.

Eur J Med Chem. 2013 Sep;67:175-87. doi: 10.1016/j.ejmech.2013.03.070. Epub 2013 May 14.

PMID:
23867602
6.

Structure-driven HtL: design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity.

Stocks MJ, Barber S, Ford R, Leroux F, St-Gallay S, Teague S, Xue Y.

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3459-62.

PMID:
15950471
7.

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.

Swahn BM, Huerta F, Kallin E, Malmström J, Weigelt T, Viklund J, Womack P, Xue Y, Ohberg L.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9.

PMID:
16140012
8.

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

Chrencik JE, Patny A, Leung IK, Korniski B, Emmons TL, Hall T, Weinberg RA, Gormley JA, Williams JM, Day JE, Hirsch JL, Kiefer JR, Leone JW, Fischer HD, Sommers CD, Huang HC, Jacobsen EJ, Tenbrink RE, Tomasselli AG, Benson TE.

J Mol Biol. 2010 Jul 16;400(3):413-33. doi: 10.1016/j.jmb.2010.05.020. Epub 2010 May 15.

PMID:
20478313
9.

Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.

Parker LJ, Taruya S, Tsuganezawa K, Ogawa N, Mikuni J, Honda K, Tomabechi Y, Handa N, Shirouzu M, Yokoyama S, Tanaka A.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):392-404. doi: 10.1107/S1399004713028654. Epub 2014 Jan 29.

PMID:
24531473
10.

A new regulatory switch in a JAK protein kinase.

Tsui V, Gibbons P, Ultsch M, Mortara K, Chang C, Blair W, Pulk R, Stanley M, Starovasnik M, Williams D, Lamers M, Leonard P, Magnuson S, Liang J, Eigenbrot C.

Proteins. 2011 Feb;79(2):393-401. doi: 10.1002/prot.22889.

PMID:
21117080
11.

Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.

Kutach AK, Villaseñor AG, Lam D, Belunis C, Janson C, Lok S, Hong LN, Liu CM, Deval J, Novak TJ, Barnett JW, Chu W, Shaw D, Kuglstatter A.

Chem Biol Drug Des. 2010 Aug;76(2):154-63. doi: 10.1111/j.1747-0285.2010.00993.x. Epub 2010 Jun 9.

PMID:
20545945
12.

Selective JAK1 inhibitor and selective Tyk2 inhibitor patents.

Norman P.

Expert Opin Ther Pat. 2012 Oct;22(10):1233-49. Epub 2012 Sep 13. Review.

PMID:
22971156
13.

Crystallography for protein kinase drug design: PKA and SRC case studies.

Breitenlechner CB, Bossemeyer D, Engh RA.

Biochim Biophys Acta. 2005 Dec 30;1754(1-2):38-49. Epub 2005 Oct 21. Review.

PMID:
16269279
14.

Crystallization to obtain protein-ligand complexes for structure-aided drug design.

Danley DE.

Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):569-75. Epub 2006 May 12.

PMID:
16699182
15.

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D.

J Am Chem Soc. 2009 Sep 23;131(37):13286-96. doi: 10.1021/ja902010p.

PMID:
19572644
16.

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.

Liang J, van Abbema A, Balazs M, Barrett K, Berezhkovsky L, Blair W, Chang C, Delarosa D, DeVoss J, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liu Y, Lyssikatos J, Mantik P, Menghrajani K, Murray J, Peng I, Sambrone A, Shia S, Shin Y, Smith J, Sohn S, Tsui V, Ultsch M, Wu LC, Xiao Y, Yang W, Young J, Zhang B, Zhu BY, Magnuson S.

J Med Chem. 2013 Jun 13;56(11):4521-36. doi: 10.1021/jm400266t. Epub 2013 May 29.

PMID:
23668484
17.

Therapeutic potential of tyrosine kinase 2 in autoimmunity.

Liang Y, Zhu Y, Xia Y, Peng H, Yang XK, Liu YY, Xu WD, Pan HF, Ye DQ.

Expert Opin Ther Targets. 2014 May;18(5):571-80. doi: 10.1517/14728222.2014.892925. Epub 2014 Mar 21. Review.

PMID:
24654603
18.

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.

Pastor RM, Burch JD, Magnuson S, Ortwine DF, Chen Y, De La Torre K, Ding X, Eigenbrot C, Johnson A, Liimatta M, Liu Y, Shia S, Wang X, Wu LC, Pei Z.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2448-52. doi: 10.1016/j.bmcl.2014.04.023. Epub 2014 Apr 16.

PMID:
24767842
19.

Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors.

Vulpetti A, Casale E, Roletto F, Amici R, Villa M, Pevarello P.

J Mol Graph Model. 2006 Mar;24(5):341-8. Epub 2005 Nov 2.

PMID:
16260160
20.

Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.

Williams NK, Bamert RS, Patel O, Wang C, Walden PM, Wilks AF, Fantino E, Rossjohn J, Lucet IS.

J Mol Biol. 2009 Mar 20;387(1):219-32. doi: 10.1016/j.jmb.2009.01.041. Epub 2009 Jan 29.

PMID:
19361440
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