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Results: 1 to 20 of 113

1.

A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.

McKoy AF, Chen J, Schupbach T, Hecht MH.

J Biol Chem. 2012 Nov 9;287(46):38992-9000. doi: 10.1074/jbc.M112.348037. Epub 2012 Sep 19.

PMID:
22992731
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structure-Activity Relationships for a Series of Compounds that Inhibit Aggregation of the Alzheimer's Peptide, Aβ42.

McKoy AF, Chen J, Schupbach T, Hecht MH.

Chem Biol Drug Des. 2014 Apr 18. doi: 10.1111/cbdd.12341. [Epub ahead of print]

PMID:
24751138
[PubMed - as supplied by publisher]
3.

Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.

Kim W, Hecht MH.

J Biol Chem. 2005 Oct 14;280(41):35069-76. Epub 2005 Aug 3.

PMID:
16079141
[PubMed - indexed for MEDLINE]
Free Article
4.

Inhibition of Abeta42 aggregation using peptides selected from combinatorial libraries.

Baine M, Georgie DS, Shiferraw EZ, Nguyen TP, Nogaj LA, Moffet DA.

J Pept Sci. 2009 Aug;15(8):499-503. doi: 10.1002/psc.1150.

PMID:
19562726
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A plant cell-based system that predicts aβ42 misfolding: potential as a drug discovery tool for Alzheimer's disease.

Zhao T, Zeng Y, Kermode AR.

Mol Genet Metab. 2012 Nov;107(3):571-9. doi: 10.1016/j.ymgme.2012.08.010. Epub 2012 Aug 18.

PMID:
22944366
[PubMed - indexed for MEDLINE]
6.

Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility.

Lee LL, Ha H, Chang YT, DeLisa MP.

Protein Sci. 2009 Feb;18(2):277-86. doi: 10.1002/pro.33.

PMID:
19177561
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.

Jan A, Gokce O, Luthi-Carter R, Lashuel HA.

J Biol Chem. 2008 Oct 17;283(42):28176-89. doi: 10.1074/jbc.M803159200. Epub 2008 Aug 11.

PMID:
18694930
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit.

Diomede L, Rigacci S, Romeo M, Stefani M, Salmona M.

PLoS One. 2013;8(3):e58893. doi: 10.1371/journal.pone.0058893. Epub 2013 Mar 8.

PMID:
23520540
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.

Hong HS, Rana S, Barrigan L, Shi A, Zhang Y, Zhou F, Jin LW, Hua DH.

J Neurochem. 2009 Feb;108(4):1097-1108. doi: 10.1111/j.1471-4159.2008.05866.x.

PMID:
19141069
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide.

Kim W, Kim Y, Min J, Kim DJ, Chang YT, Hecht MH.

ACS Chem Biol. 2006 Aug 22;1(7):461-9.

PMID:
17168524
[PubMed - indexed for MEDLINE]
11.

Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein.

Zheng X, Gessel MM, Wisniewski ML, Viswanathan K, Wright DL, Bahr BA, Bowers MT.

J Biol Chem. 2012 Feb 24;287(9):6084-8. doi: 10.1074/jbc.C111.328575. Epub 2012 Jan 17.

PMID:
22253440
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles.

Han SH, Chang YJ, Jung ES, Kim JW, Na DL, Mook-Jung I.

Int J Nanomedicine. 2010 Dec 15;6:1-12. doi: 10.2147/IJN.S15278.

PMID:
21289976
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.

Mustafi SM, Garai K, Crick SL, Baban B, Frieden C.

Biochem Biophys Res Commun. 2010 Jul 2;397(3):509-12. doi: 10.1016/j.bbrc.2010.05.144. Epub 2010 May 31.

PMID:
20515649
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity.

Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G.

Biochemistry. 2010 Feb 16;49(6):1259-67. doi: 10.1021/bi902075h.

PMID:
20050679
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Diverse ecdysterones show different effects on amyloid-β42 aggregation but all uniformly inhibit amyloid-β42-induced cytotoxicity.

Yang SG, Zhang X, Sun XS, Ling TJ, Feng Y, Du XY, Zhao M, Yang Y, Xue D, Wang L, Liu RT.

J Alzheimers Dis. 2010;22(1):107-17. doi: 10.3233/JAD-2010-100621.

PMID:
20847437
[PubMed - indexed for MEDLINE]
16.

Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease.

Izuo N, Murakami K, Sato M, Iwasaki M, Izumi Y, Shimizu T, Akaike A, Irie K, Kume T.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):1-5. doi: 10.1016/j.bbrc.2013.05.106. Epub 2013 Jun 4.

PMID:
23747423
[PubMed - indexed for MEDLINE]
17.

Retro-inversal of intracellular selected β-amyloid-interacting peptides: implications for a novel Alzheimer's disease treatment.

Acerra N, Kad NM, Griffith DA, Ott S, Crowther DC, Mason JM.

Biochemistry. 2014 Apr 8;53(13):2101-11. doi: 10.1021/bi5001257. Epub 2014 Mar 21.

PMID:
24601543
[PubMed - indexed for MEDLINE]
18.

Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.

Sato M, Murakami K, Uno M, Nakagawa Y, Katayama S, Akagi K, Masuda Y, Takegoshi K, Irie K.

J Biol Chem. 2013 Aug 9;288(32):23212-24. doi: 10.1074/jbc.M113.464222. Epub 2013 Jun 21.

PMID:
23792961
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.

Izuo N, Kume T, Sato M, Murakami K, Irie K, Izumi Y, Akaike A.

ACS Chem Neurosci. 2012 Sep 19;3(9):674-81. Epub 2012 Jun 6.

PMID:
23019494
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.

Li H, Zemel R, Lopes DH, Monien BH, Bitan G.

ChemMedChem. 2012 Mar 5;7(3):515-22. doi: 10.1002/cmdc.201100584. Epub 2012 Feb 3.

PMID:
22307963
[PubMed - indexed for MEDLINE]
Free PMC Article

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