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Results: 1 to 20 of 100

1.

Protective effects of alanyl-glutamine supplementation against nelfinavir-induced epithelial impairment in IEC-6 cells and in mouse intestinal mucosa.

Braga-Neto MB, Oliveira BM, Rodrigues RS, Noronha FJ, Leitao RF, Brito GA, Lima AA, Guerrant RL, Warren CA.

Cancer Biol Ther. 2012 Dec;13(14):1482-90. doi: 10.4161/cbt.22251. Epub 2012 Sep 17.

PMID:
22986234
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice.

Braga Neto MB, Aguiar CV, Maciel JG, Oliveira BM, Sevilleja JE, Oriá RB, Brito GA, Warren CA, Guerrant RL, Lima AA.

BMC Gastroenterol. 2010 Aug 11;10:90. doi: 10.1186/1471-230X-10-90.

PMID:
20701796
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro-evidence for a TGF--beta-mediated effect.

Bulut K, Meier JJ, Ansorge N, Felderbauer P, Schmitz F, Hoffmann P, Schmidt WE, Gallwitz B.

Regul Pept. 2004 Sep 15;121(1-3):137-43.

PMID:
15256284
[PubMed - indexed for MEDLINE]
4.

Intestinal epithelial restitution after TcdB challenge and recovery from Clostridium difficile infection in mice with alanyl-glutamine treatment.

Rodrigues RS, Oliveira RA, Li Y, Zaja-Milatovic S, Costa LB, Braga Neto MB, Kolling GL, Lima AA, Guerrant RL, Warren CA.

J Infect Dis. 2013 May 15;207(10):1505-15. doi: 10.1093/infdis/jit041. Epub 2013 Jan 28.

PMID:
23359592
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro.

Braga-Neto MB, Warren CA, Oriá RB, Monteiro MS, Maciel AA, Brito GA, Lima AA, Guerrant RL.

Dig Dis Sci. 2008 Oct;53(10):2687-96. doi: 10.1007/s10620-008-0215-0. Epub 2008 Mar 6.

PMID:
18320312
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Clostridium difficile toxin A induces intestinal epithelial cell apoptosis and damage: role of Gln and Ala-Gln in toxin A effects.

Brito GA, Carneiro-Filho B, Oriá RB, Destura RV, Lima AA, Guerrant RL.

Dig Dis Sci. 2005 Jul;50(7):1271-8.

PMID:
16047471
[PubMed - indexed for MEDLINE]
7.

NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines.

Yang Y, Ikezoe T, Nishioka C, Bandobashi K, Takeuchi T, Adachi Y, Kobayashi M, Takeuchi S, Koeffler HP, Taguchi H.

Br J Cancer. 2006 Dec 18;95(12):1653-62. Epub 2006 Nov 28.

PMID:
17133272
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir induce apoptosis and decrease barrier function in human intestinal epithelial cells.

Bode H, Lenzner L, Kraemer OH, Kroesen AJ, Bendfeldt K, Schulzke JD, Fromm M, Stoltenburg-Didinger G, Zeitz M, Ullrich R.

Antivir Ther. 2005;10(5):645-55.

PMID:
16152758
[PubMed - indexed for MEDLINE]
9.

Effects of azathioprine and its metabolites on repair mechanisms of the intestinal epithelium in vitro.

Schroll S, Sarlette A, Ahrens K, Manns MP, Göke M.

Regul Pept. 2005 Nov;131(1-3):1-11.

PMID:
16122821
[PubMed - indexed for MEDLINE]
10.

The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo.

Bono C, Karlin L, Harel S, Mouly E, Labaume S, Galicier L, Apcher S, Sauvageon H, Fermand JP, Bories JC, Arnulf B.

Haematologica. 2012 Jul;97(7):1101-9. doi: 10.3324/haematol.2011.049981. Epub 2012 Jan 22.

PMID:
22271897
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling.

Yang Y, Ikezoe T, Takeuchi T, Adachi Y, Ohtsuki Y, Takeuchi S, Koeffler HP, Taguchi H.

Cancer Sci. 2005 Jul;96(7):425-33.

PMID:
16053514
[PubMed - indexed for MEDLINE]
12.

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.

Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, Borojerdi J, Warfel NA, Gardner ER, Danish M, Hollander MC, Kawabata S, Tsokos M, Figg WD, Steeg PS, Dennis PA.

Clin Cancer Res. 2007 Sep 1;13(17):5183-94.

PMID:
17785575
[PubMed - indexed for MEDLINE]
Free Article
13.

Effects of exogenous zinc supplementation on intestinal epithelial repair in vitro.

Cario E, Jung S, Harder D'Heureuse J, Schulte C, Sturm A, Wiedenmann B, Goebell H, Dignass AU.

Eur J Clin Invest. 2000 May;30(5):419-28.

PMID:
10809902
[PubMed - indexed for MEDLINE]
14.

Vascular endothelial growth factor (VEGF164) ameliorates intestinal epithelial injury in vitro in IEC-18 and Caco-2 monolayers via induction of TGF-beta release from epithelial cells.

Bulut K, Pennartz C, Felderbauer P, Ansorge N, Banasch M, Schmitz F, Schmidt WE, Hoffmann P.

Scand J Gastroenterol. 2006 Jun;41(6):687-92.

PMID:
16716967
[PubMed - indexed for MEDLINE]
15.

Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis.

Singh VP, Bren GD, Algeciras-Schimnich A, Schnepple D, Navina S, Rizza SA, Dawra RK, Saluja AK, Chari ST, Vege SS, Badley AD.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1040-6. doi: 10.1152/ajpgi.90642.2008. Epub 2009 Mar 12.

PMID:
19282375
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition.

Ueno PM, Oriá RB, Maier EA, Guedes M, de Azevedo OG, Wu D, Willson T, Hogan SP, Lima AA, Guerrant RL, Polk DB, Denson LA, Moore SR.

Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G612-22. doi: 10.1152/ajpgi.00531.2010. Epub 2011 Jul 28.

PMID:
21799183
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Glutamine and alanyl-glutamine increase RhoA expression and reduce Clostridium difficile toxin-a-induced intestinal epithelial cell damage.

Santos AA, Braga-Neto MB, Oliveira MR, Freire RS, Barros EB, Santiago TM, Rebelo LM, Mermelstein C, Warren CA, Guerrant RL, Brito GA.

Biomed Res Int. 2013;2013:152052. doi: 10.1155/2013/152052. Epub 2012 Dec 27.

PMID:
23484083
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Effects of Ganoderma lucidum polysaccharides on IEC-6 cell proliferation, migration and morphology of differentiation benefiting intestinal epithelium healing in vitro.

Sun LX, Chen LH, Lin ZB, Qin Y, Zhang JQ, Yang J, Ma J, Ye T, Li WD.

J Pharm Pharmacol. 2011 Dec;63(12):1595-603. doi: 10.1111/j.2042-7158.2011.01367.x. Epub 2011 Oct 13.

PMID:
22060291
[PubMed - indexed for MEDLINE]
19.

In vivo effects of highly active antiretroviral therapies containing the protease inhibitor nelfinavir on mitochondrially driven apoptosis.

Miró O, Villarroya J, Garrabou G, López S, Rodríguez de la Concepción M, Pedrol E, Martínez E, Giralt M, Gatell JM, Cardellach F, Casademont J, Villarroya F.

Antivir Ther. 2005;10(8):945-51.

PMID:
16430200
[PubMed - indexed for MEDLINE]
20.

Corticosteroids impair intestinal epithelial wound repair mechanisms in vitro.

Jung S, Fehr S, Harder-d'Heureuse J, Wiedenmann B, Dignass AU.

Scand J Gastroenterol. 2001 Sep;36(9):963-70.

PMID:
11521988
[PubMed - indexed for MEDLINE]

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