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The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.

Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q.

Nat Chem Biol. 2012 Nov;8(11):897-904. doi: 10.1038/nchembio.1069. Epub 2012 Sep 16.


A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro.

Liu JJ, Zeng HN, Zhang LR, Zhan YY, Chen Y, Wang Y, Wang J, Xiang SH, Liu WJ, Wang WJ, Chen HZ, Shen YM, Su WJ, Huang PQ, Zhang HK, Wu Q.

Cancer Res. 2010 May 1;70(9):3628-37. doi: 10.1158/0008-5472.CAN-09-3160. Epub 2010 Apr 13.


The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.

Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L.

J Biol Chem. 2010 Dec 24;285(52):40581-92. doi: 10.1074/jbc.M110.176545. Epub 2010 Oct 18.


eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1.

Thors B, Halld├│rsson H, Thorgeirsson G.

Biochim Biophys Acta. 2011 Feb;1813(2):322-31. doi: 10.1016/j.bbamcr.2010.12.001. Epub 2010 Dec 9.


B-cell translocation gene 2 regulates hepatic glucose homeostasis via induction of orphan nuclear receptor Nur77 in diabetic mouse model.

Kim YD, Kim SG, Hwang SL, Choi HS, Bae JH, Song DK, Im SS.

Diabetes. 2014 Jun;63(6):1870-80. doi: 10.2337/db13-1368. Epub 2014 Mar 19.


Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway.

Murase T, Misawa K, Haramizu S, Hase T.

Biochem Pharmacol. 2009 Jul 1;78(1):78-84. doi: 10.1016/j.bcp.2009.03.021. Epub 2009 Mar 31.


AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.

Zhang YL, Guo H, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC.

Cell Metab. 2013 Oct 1;18(4):546-55. doi: 10.1016/j.cmet.2013.09.005.


Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

Sakamoto K, G├Âransson O, Hardie DG, Alessi DR.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E310-7. Epub 2004 Apr 6.


Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders.

Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F.

Diabetes Metab. 2007 Dec;33(6):395-402. Epub 2007 Nov 7. Review.


Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

Han CY, Ki SH, Kim YW, Noh K, Lee da Y, Kang B, Ryu JH, Jeon R, Kim EH, Hwang SJ, Kim SG.

Antioxid Redox Signal. 2011 Jan 15;14(2):187-202. doi: 10.1089/ars.2010.3190. Epub 2010 Sep 6.


Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase.

Yamada E, Bastie CC.

PLoS One. 2014 Feb 25;9(2):e89604. doi: 10.1371/journal.pone.0089604. eCollection 2014.


The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.

Cao Y, Li H, Liu H, Zheng C, Ji H, Liu X.

Cell Res. 2010 Jan;20(1):99-108. doi: 10.1038/cr.2009.141. Epub 2009 Dec 22.


Cytosporone B is an agonist for nuclear orphan receptor Nur77.

Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC, Shen Y, Wu Q.

Nat Chem Biol. 2008 Sep;4(9):548-56. doi: 10.1038/nchembio.106.


SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.

Zu Y, Liu L, Lee MY, Xu C, Liang Y, Man RY, Vanhoutte PM, Wang Y.

Circ Res. 2010 Apr 30;106(8):1384-93. doi: 10.1161/CIRCRESAHA.109.215483. Epub 2010 Mar 4.


Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice.

Quan HY, Yuan HD, Jung MS, Ko SK, Park YG, Chung SH.

Int J Mol Med. 2012 Jan;29(1):73-80. doi: 10.3892/ijmm.2011.805. Epub 2011 Oct 3.


Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH.

J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.


Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.

Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC, Singh G, Wright J, Tsakiridis T.

Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):221-9. doi: 10.1016/j.ijrobp.2010.03.005. Epub 2010 Jul 7.


Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase.

Wu Y, Song P, Xu J, Zhang M, Zou MH.

J Biol Chem. 2007 Mar 30;282(13):9777-88. Epub 2007 Jan 25.


MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.

Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K.

Circ Res. 2015 Jan 16;116(2):279-88. doi: 10.1161/CIRCRESAHA.116.304707. Epub 2014 Oct 31.


Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.

Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q.

Nat Chem Biol. 2015 May;11(5):339-46. doi: 10.1038/nchembio.1788. Epub 2015 Mar 30.

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