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Results: 1 to 20 of 152

1.

A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia.

Dorn KV, Hughes CE, Rohatgi R.

Dev Cell. 2012 Oct 16;23(4):823-35. doi: 10.1016/j.devcel.2012.07.004. Epub 2012 Sep 13.

PMID:
22981989
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

Yang C, Chen W, Chen Y, Jiang J.

Cell Res. 2012 Nov;22(11):1593-604. doi: 10.1038/cr.2012.134. Epub 2012 Sep 18.

PMID:
22986504
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.

Caparrós-Martín JA, Valencia M, Reytor E, Pacheco M, Fernandez M, Perez-Aytes A, Gean E, Lapunzina P, Peters H, Goodship JA, Ruiz-Perez VL.

Hum Mol Genet. 2013 Jan 1;22(1):124-39. doi: 10.1093/hmg/dds409. Epub 2012 Oct 1.

PMID:
23026747
[PubMed - indexed for MEDLINE]
Free Article
4.

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.

Tukachinsky H, Lopez LV, Salic A.

J Cell Biol. 2010 Oct 18;191(2):415-28. doi: 10.1083/jcb.201004108.

PMID:
20956384
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.

Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R.

Dev Cell. 2014 Mar 10;28(5):483-96. doi: 10.1016/j.devcel.2014.01.021. Epub 2014 Feb 27.

PMID:
24582806
[PubMed - indexed for MEDLINE]
6.

Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus.

Blair HJ, Tompson S, Liu YN, Campbell J, MacArthur K, Ponting CP, Ruiz-Perez VL, Goodship JA.

BMC Biol. 2011 Feb 28;9:14. doi: 10.1186/1741-7007-9-14.

PMID:
21356043
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL.

PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534. eCollection 2014.

PMID:
24608250
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.

Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, Toftgård R, Liu A.

Dev Biol. 2009 Jun 15;330(2):452-60. doi: 10.1016/j.ydbio.2009.04.009. Epub 2009 Apr 14.

PMID:
19371734
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.

Chen Y, Sasai N, Ma G, Yue T, Jia J, Briscoe J, Jiang J.

PLoS Biol. 2011 Jun;9(6):e1001083. doi: 10.1371/journal.pbio.1001083. Epub 2011 Jun 14.

PMID:
21695114
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Patched1 regulates hedgehog signaling at the primary cilium.

Rohatgi R, Milenkovic L, Scott MP.

Science. 2007 Jul 20;317(5836):372-6.

PMID:
17641202
[PubMed - indexed for MEDLINE]
Free Article
11.

Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.

Bijlsma MF, Damhofer H, Roelink H.

Sci Signal. 2012 Aug 21;5(238):ra60. doi: 10.1126/scisignal.2002798.

PMID:
22912493
[PubMed - indexed for MEDLINE]
Free Article
12.

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling.

Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, Martelotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE.

EMBO Rep. 2013 Sep;14(9):837-44. doi: 10.1038/embor.2013.110. Epub 2013 Jul 23. Erratum in: EMBO Rep. 2013 Oct;14(10):945. Martellotto, Luciano G [corrected to Martelotto, Luciano G].

PMID:
23877428
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.

Wang Y, Arvanites AC, Davidow L, Blanchard J, Lam K, Yoo JW, Coy S, Rubin LL, McMahon AP.

ACS Chem Biol. 2012 Jun 15;7(6):1040-8. doi: 10.1021/cb300028a. Epub 2012 May 3.

PMID:
22554036
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.

Lu J, Chen M, Ren XR, Wang J, Lyerly HK, Barak L, Chen W.

PLoS One. 2013 May 3;8(5):e63353. doi: 10.1371/journal.pone.0063353. Print 2013.

PMID:
23671675
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.

Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W, Caron MG.

J Biol Chem. 2011 Aug 5;286(31):27676-86. doi: 10.1074/jbc.M111.234666. Epub 2011 Jun 8.

PMID:
21659505
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Widening the mutation spectrum of EVC and EVC2: ectopic expression of Weyer variants in NIH 3T3 fibroblasts disrupts Hedgehog signaling.

Valencia M, Lapunzina P, Lim D, Zannolli R, Bartholdi D, Wollnik B, Al-Ajlouni O, Eid SS, Cox H, Buoni S, Hayek J, Martinez-Frias ML, Antonio PA, Temtamy S, Aglan M, Goodship JA, Ruiz-Perez VL.

Hum Mutat. 2009 Dec;30(12):1667-75. doi: 10.1002/humu.21117.

PMID:
19810119
[PubMed - indexed for MEDLINE]
17.

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.

Rohatgi R, Milenkovic L, Corcoran RB, Scott MP.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3196-201. doi: 10.1073/pnas.0813373106. Epub 2009 Feb 13.

PMID:
19218434
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.

Wang Y, Zhou Z, Walsh CT, McMahon AP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2623-8. doi: 10.1073/pnas.0812110106. Epub 2009 Feb 5.

PMID:
19196978
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.

Wu VM, Chen SC, Arkin MR, Reiter JF.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13644-9. doi: 10.1073/pnas.1207170109. Epub 2012 Aug 3.

PMID:
22864913
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus.

Kim J, Kato M, Beachy PA.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21666-71. doi: 10.1073/pnas.0912180106. Epub 2009 Dec 8.

PMID:
19996169
[PubMed - indexed for MEDLINE]
Free PMC Article

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