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Results: 1 to 20 of 92

1.

Molecular insight in the multifunctional activities of Withaferin A.

Vanden Berghe W, Sabbe L, Kaileh M, Haegeman G, Heyninck K.

Biochem Pharmacol. 2012 Nov 15;84(10):1282-91. doi: 10.1016/j.bcp.2012.08.027. Epub 2012 Sep 6. Review.

PMID:
22981382
[PubMed - indexed for MEDLINE]
2.

Withaferin A is a potent inhibitor of angiogenesis.

Mohan R, Hammers HJ, Bargagna-Mohan P, Zhan XH, Herbstritt CJ, Ruiz A, Zhang L, Hanson AD, Conner BP, Rougas J, Pribluda VS.

Angiogenesis. 2004;7(2):115-22.

PMID:
15516832
[PubMed - indexed for MEDLINE]
3.

Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo.

Yang H, Wang Y, Cheryan VT, Wu W, Cui CQ, Polin LA, Pass HI, Dou QP, Rishi AK, Wali A.

PLoS One. 2012;7(8):e41214. doi: 10.1371/journal.pone.0041214. Epub 2012 Aug 17.

PMID:
22912669
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.

Vaishnavi K, Saxena N, Shah N, Singh R, Manjunath K, Uthayakumar M, Kanaujia SP, Kaul SC, Sekar K, Wadhwa R.

PLoS One. 2012;7(9):e44419. doi: 10.1371/journal.pone.0044419. Epub 2012 Sep 4.

PMID:
22973447
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Epoxide group relationship with cytotoxicity in withanolide derivatives from Withania somnifera.

Joshi P, Misra L, Siddique AA, Srivastava M, Kumar S, Darokar MP.

Steroids. 2014 Jan;79:19-27. doi: 10.1016/j.steroids.2013.10.008. Epub 2013 Nov 1.

PMID:
24184562
[PubMed - indexed for MEDLINE]
6.

Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes.

Grover A, Shandilya A, Bisaria VS, Sundar D.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S15. doi: 10.1186/1471-2164-11-S4-S15.

PMID:
21143798
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells.

Llanos GG, Araujo LM, Jiménez IA, Moujir LM, Bazzocchi IL.

Eur J Med Chem. 2012 Aug;54:499-511. doi: 10.1016/j.ejmech.2012.05.032. Epub 2012 Jun 1.

PMID:
22705001
[PubMed - indexed for MEDLINE]
8.

Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition.

Yang ES, Choi MJ, Kim JH, Choi KS, Kwon TK.

Chem Biol Interact. 2011 Mar 15;190(1):9-15. doi: 10.1016/j.cbi.2011.01.015. Epub 2011 Jan 21.

PMID:
21256832
[PubMed - indexed for MEDLINE]
9.

Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line.

Choudhary MI, Hussain S, Yousuf S, Dar A, Mudassar, Atta-ur-Rahman.

Phytochemistry. 2010 Dec;71(17-18):2205-9. doi: 10.1016/j.phytochem.2010.08.019. Epub 2010 Oct 31.

PMID:
21044792
[PubMed - indexed for MEDLINE]
10.

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells.

Choi MJ, Park EJ, Min KJ, Park JW, Kwon TK.

Toxicol In Vitro. 2011 Apr;25(3):692-8. doi: 10.1016/j.tiv.2011.01.010. Epub 2011 Jan 23.

PMID:
21266191
[PubMed - indexed for MEDLINE]
11.

Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.

Kaileh M, Vanden Berghe W, Heyerick A, Horion J, Piette J, Libert C, De Keukeleire D, Essawi T, Haegeman G.

J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.

PMID:
17150968
[PubMed - indexed for MEDLINE]
Free Article
12.

Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.

Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB.

Mol Cancer Ther. 2006 Jun;5(6):1434-45.

PMID:
16818501
[PubMed - indexed for MEDLINE]
Free Article
13.

Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha.

Ven Murthy MR, Ranjekar PK, Ramassamy C, Deshpande M.

Cent Nerv Syst Agents Med Chem. 2010 Sep 1;10(3):238-46. Review.

PMID:
20528765
[PubMed - indexed for MEDLINE]
14.

Unusual withanolides from aeroponically grown Withania somnifera.

Xu YM, Gao S, Bunting DP, Gunatilaka AA.

Phytochemistry. 2011 Apr;72(6):518-22. doi: 10.1016/j.phytochem.2010.12.020.

PMID:
21315384
[PubMed - indexed for MEDLINE]
15.

Paraminabeolides A-F, cytotoxic and anti-inflammatory marine withanolides from the soft coral Paraminabea acronocephala.

Chao CH, Chou KJ, Wen ZH, Wang GH, Wu YC, Dai CF, Sheu JH.

J Nat Prod. 2011 May 27;74(5):1132-41. doi: 10.1021/np2000705. Epub 2011 Mar 22.

PMID:
21425785
[PubMed - indexed for MEDLINE]
16.

Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity.

Kaileh M, Vanden Berghe W, Boone E, Essawi T, Haegeman G.

J Ethnopharmacol. 2007 Sep 25;113(3):510-6. Epub 2007 Jul 14.

PMID:
17716845
[PubMed - indexed for MEDLINE]
17.

Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.

Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA.

J Med Chem. 2014 Apr 10;57(7):2851-63. doi: 10.1021/jm401279n. Epub 2014 Mar 25.

PMID:
24625088
[PubMed - indexed for MEDLINE]
18.

Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, isoenzyme, polypeptide and withanolide profile diversity.

Chaurasiya ND, Sangwan RS, Misra LN, Tuli R, Sangwan NS.

Fitoterapia. 2009 Dec;80(8):496-505. doi: 10.1016/j.fitote.2009.06.012. Epub 2009 Jun 24.

PMID:
19559768
[PubMed - indexed for MEDLINE]
19.

2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.

Xu YM, Marron MT, Seddon E, McLaughlin SP, Ray DT, Whitesell L, Gunatilaka AA.

Bioorg Med Chem. 2009 Mar 15;17(6):2210-4. doi: 10.1016/j.bmc.2008.10.091. Epub 2008 Nov 12.

PMID:
19056281
[PubMed - indexed for MEDLINE]
20.

Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies.

Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J, Torres K, Langley RR, Lazar AJ, Hung MC, Lev D.

PLoS One. 2010 Apr 16;5(4):e10105. doi: 10.1371/journal.pone.0010105.

PMID:
20419128
[PubMed - indexed for MEDLINE]
Free PMC Article

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