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Items: 1 to 20 of 125

1.

A kinetic-metabolic model based on cell energetic state: study of CHO cell behavior under Na-butyrate stimulation.

Ghorbaniaghdam A, Henry O, Jolicoeur M.

Bioprocess Biosyst Eng. 2013 Apr;36(4):469-87. doi: 10.1007/s00449-012-0804-3. Epub 2012 Sep 14.

PMID:
22976819
2.

Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells.

McMurray-Beaulieu V, Hisiger S, Durand C, Perrier M, Jolicoeur M.

J Biosci Bioeng. 2009 Aug;108(2):160-7. doi: 10.1016/j.jbiosc.2009.03.001.

PMID:
19619865
3.

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism.

Ma N, Ellet J, Okediadi C, Hermes P, McCormick E, Casnocha S.

Biotechnol Prog. 2009 Sep-Oct;25(5):1353-63. doi: 10.1002/btpr.238.

PMID:
19637321
4.

Parallel labeling experiments with [1,2-(13)C]glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism.

Ahn WS, Antoniewicz MR.

Metab Eng. 2013 Jan;15:34-47. doi: 10.1016/j.ymben.2012.10.001. Epub 2012 Oct 27.

PMID:
23111062
5.

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry.

Ahn WS, Antoniewicz MR.

Metab Eng. 2011 Sep;13(5):598-609. doi: 10.1016/j.ymben.2011.07.002. Epub 2011 Aug 2.

PMID:
21821143
6.

Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy.

Goudar C, Biener R, Boisart C, Heidemann R, Piret J, de Graaf A, Konstantinov K.

Metab Eng. 2010 Mar;12(2):138-49. doi: 10.1016/j.ymben.2009.10.007. Epub 2009 Nov 5.

PMID:
19896555
7.

An in-silico study of the regulation of CHO cells glycolysis.

Ghorbaniaghdam A, Henry O, Jolicoeur M.

J Theor Biol. 2014 Sep 21;357:112-22. doi: 10.1016/j.jtbi.2014.04.035. Epub 2014 May 4.

PMID:
24801859
8.

Metabolic analysis of antibody producing CHO cells in fed-batch production.

Dean J, Reddy P.

Biotechnol Bioeng. 2013 Jun;110(6):1735-47. doi: 10.1002/bit.24826. Epub 2013 Feb 15.

PMID:
23296898
9.

Metabolic flux analysis of CHO cell metabolism in the late non-growth phase.

Sengupta N, Rose ST, Morgan JA.

Biotechnol Bioeng. 2011 Jan;108(1):82-92. doi: 10.1002/bit.22890.

PMID:
20672285
10.

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process.

Luo J, Vijayasankaran N, Autsen J, Santuray R, Hudson T, Amanullah A, Li F.

Biotechnol Bioeng. 2012 Jan;109(1):146-56. doi: 10.1002/bit.23291. Epub 2011 Oct 16.

PMID:
21964570
11.

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition.

Carinhas N, Duarte TM, Barreiro LC, Carrondo MJ, Alves PM, Teixeira AP.

Biotechnol Bioeng. 2013 Dec;110(12):3244-57. doi: 10.1002/bit.24983. Epub 2013 Jul 7.

PMID:
23794452
12.

Effect of N-Acetylcystein on butyrate-treated Chinese hamster ovary cells to improve the production of recombinant human interferon-beta-1a.

Oh HK, So MK, Yang J, Yoon HC, Ahn JS, Lee JM, Kim JT, Yoo JU, Byun TH.

Biotechnol Prog. 2005 Jul-Aug;21(4):1154-64.

PMID:
16080696
13.

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption.

Martínez VS, Dietmair S, Quek LE, Hodson MP, Gray P, Nielsen LK.

Biotechnol Bioeng. 2013 Feb;110(2):660-6. doi: 10.1002/bit.24728. Epub 2012 Nov 5.

PMID:
22991240
14.

Towards industrial application of quasi real-time metabolic flux analysis for mammalian cell culture.

Goudar C, Biener R, Zhang C, Michaels J, Piret J, Konstantinov K.

Adv Biochem Eng Biotechnol. 2006;101:99-118.

PMID:
16989259
15.
16.

Modeling kinetics of a large-scale fed-batch CHO cell culture by Markov chain Monte Carlo method.

Xing Z, Bishop N, Leister K, Li ZJ.

Biotechnol Prog. 2010 Jan-Feb;26(1):208-19. doi: 10.1002/btpr.284.

PMID:
19834967
17.

Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells.

Burleigh SC, van de Laar T, Stroop CJ, van Grunsven WM, O'Donoghue N, Rudd PM, Davey GP.

BMC Biotechnol. 2011 Oct 18;11:95. doi: 10.1186/1472-6750-11-95.

18.

LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells.

Chong WP, Thng SH, Hiu AP, Lee DY, Chan EC, Ho YS.

Biotechnol Bioeng. 2012 Dec;109(12):3103-11. doi: 10.1002/bit.24580. Epub 2012 Jul 4.

PMID:
22711553
19.

Continuous modeling of metabolic networks with gene regulation in yeast and in vivo determination of rate parameters.

Moisset P, Vaisman D, Cintolesi A, Urrutia J, Rapaport I, Andrews BA, Asenjo JA.

Biotechnol Bioeng. 2012 Sep;109(9):2325-39. doi: 10.1002/bit.24503. Epub 2012 Apr 24.

PMID:
22447363
20.
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