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Items: 1 to 20 of 81

1.

Mechanism of inverse agonist action of sarpogrelate at the constitutively active mutant of human 5-HT2A receptor revealed by molecular modeling.

Hossain M, Muntasir HA, Ishiguro M, Bhuiyan MA, Rashid M, Sugihara T, Nagatomo T.

Biol Pharm Bull. 2012;35(9):1553-9.

2.

Inverse agonist activity of sarpogrelate, a selective 5-HT2A-receptor antagonist, at the constitutively active human 5-HT2A receptor.

Muntasir HA, Bhuiyan MA, Ishiguro M, Ozaki M, Nagatomo T.

J Pharmacol Sci. 2006 Oct;102(2):189-95. Epub 2006 Oct 7.

3.

Identification of amino acid residues important for sarpogrelate binding to the human 5-hydroxytryptamine2A serotonin receptor.

Muntasir HA, Rashid M, Komiyama T, Kawakami J, Nagatomo T.

J Pharmacol Sci. 2006 Sep;102(1):55-63. Epub 2006 Sep 15.

4.
5.

Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling.

Rashid M, Manivet P, Nishio H, Pratuangdejkul J, Rajab M, Ishiguro M, Launay JM, Nagatomo T.

Life Sci. 2003 May 30;73(2):193-207.

PMID:
12738034
7.

Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft.

Kodama A, Komori K, Hattori K, Yamanouchi D, Kajikuri J, Itoh T.

J Vasc Surg. 2009 May;49(5):1272-81. doi: 10.1016/j.jvs.2008.11.071. Epub 2009 Feb 23.

9.

Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors.

Aira Z, Buesa I, García del Caño G, Salgueiro M, Mendiable N, Mingo J, Aguilera L, Bilbao J, Azkue JJ.

Pain. 2012 Jul;153(7):1418-25. doi: 10.1016/j.pain.2012.03.017. Epub 2012 Apr 19.

PMID:
22520172
10.

Site-directed mutagenesis of the serotonin 5-Hydroxytryptamine2c receptor: identification of amino acids responsible for sarpogrelate binding.

Muntasir HA, Takahashi J, Rashid M, Ahmed M, Komiyama T, Hossain M, Kawakami J, Nashimoto M, Nagatomo T.

Biol Pharm Bull. 2006 Aug;29(8):1645-50.

11.

Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT(2A) receptor.

Barclay Z, Dickson L, Robertson D, Johnson M, Holland P, Rosie R, Sun L, Jerina H, Lutz E, Fleetwood-Walker S, Mitchell R.

Cell Signal. 2013 Apr;25(4):814-21. doi: 10.1016/j.cellsig.2013.01.004. Epub 2013 Jan 11.

PMID:
23314176
12.

Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts.

Fujita M, Minamino T, Sanada S, Asanuma H, Hirata A, Ogita H, Okada K, Tsukamoto O, Takashima S, Tomoike H, Node K, Hori M, Kitakaze M.

J Mol Cell Cardiol. 2004 Dec;37(6):1219-23.

PMID:
15572052
13.

Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model.

Miyata K, Shimokawa H, Higo T, Yamawaki T, Katsumata N, Kandabashi T, Tanaka E, Takamura Y, Yogo K, Egashira K, Takeshita A.

J Cardiovasc Pharmacol. 2000 Feb;35(2):294-301.

PMID:
10672864
14.

[Involvement of peripheral 5-HT2A receptor activation in inflammatory pain].

Nakanishi O, Ishikawa T.

Nihon Rinsho. 2001 Sep;59(9):1675-80. Review. Japanese.

PMID:
11554035
15.

Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy.

Kobayashi S, Satoh M, Namikoshi T, Haruna Y, Fujimoto S, Arakawa S, Komai N, Tomita N, Sasaki T, Kashihara N.

Clin Exp Nephrol. 2008 Apr;12(2):119-25. doi: 10.1007/s10157-007-0011-8. Epub 2008 Jan 5.

PMID:
18175064
16.

Sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, attenuates neurogenic pain induced by nucleus pulposus in rats.

Hashizume H, Kawakami M, Yoshida M, Okada M, Enyo Y, Inomata Y.

Spine (Phila Pa 1976). 2007 Feb 1;32(3):315-20.

PMID:
17268262
17.

Contribution of the peripheral 5-HT 2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain.

Nitanda A, Yasunami N, Tokumo K, Fujii H, Hirai T, Nishio H.

Neurochem Int. 2005 Nov;47(6):394-400.

PMID:
16051396
18.

Regulation of antigen-specific CTL and Th1 cell activation through 5-Hydroxytryptamine 2A receptor.

Inoue M, Okazaki T, Kitazono T, Mizushima M, Omata M, Ozaki S.

Int Immunopharmacol. 2011 Jan;11(1):67-73. doi: 10.1016/j.intimp.2010.10.007. Epub 2010 Oct 23.

PMID:
20971187
19.

Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants.

Labasque M, Meffre J, Carrat G, Becamel C, Bockaert J, Marin P.

Mol Pharmacol. 2010 Nov;78(5):818-26. doi: 10.1124/mol.110.066035. Epub 2010 Aug 10.

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