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Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive rats via PKCα/β2 signal pathway.

Qiu Z, Zhang W, Fan F, Li H, Wu C, Ye Y, Du Q, Li Z, Hu X, Zhao G, Sun A, Bao Z, Ge J.

J Cell Mol Med. 2012 Dec;16(12):3052-61. doi: 10.1111/j.1582-4934.2012.01632.x.


The therapeutic effect of rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats.

Zhang WB, Du QJ, Li H, Sun AJ, Qiu ZH, Wu CN, Zhao G, Gong H, Hu K, Zou YZ, Ge JB.

J Cell Mol Med. 2012 Sep;16(9):2227-37. doi: 10.1111/j.1582-4934.2012.01536.x.


Changes in myocardial gene expression associated with beta-blocker therapy in patients with chronic heart failure.

Yasumura Y, Takemura K, Sakamoto A, Kitakaze M, Miyatake K.

J Card Fail. 2003 Dec;9(6):469-74.


Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat.

Loch D, Chan V, Hoey A, Brown L.

Basic Clin Pharmacol Toxicol. 2009 Oct;105(4):262-70. doi: 10.1111/j.1742-7843.2009.00440.x. Epub 2009 Jul 2.


Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.

Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM.

Circ Res. 2005 Dec 9;97(12):1314-22. Epub 2005 Nov 3.


Effect of farnesyltransferase inhibition on cardiac remodeling in spontaneously hypertensive rats.

Li X, Han J, Li L, Wang KJ, Hu SJ.

Int J Cardiol. 2013 Oct 9;168(4):3340-7. doi: 10.1016/j.ijcard.2013.04.038. Epub 2013 May 9.


PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms.

Deres L, Bartha E, Palfi A, Eros K, Riba A, Lantos J, Kalai T, Hideg K, Sumegi B, Gallyas F, Toth K, Halmosi R.

PLoS One. 2014 Jul 11;9(7):e102148. doi: 10.1371/journal.pone.0102148. eCollection 2014.


The onset of left ventricular diastolic dysfunction in SHR rats is not related to hypertrophy or hypertension.

Dupont S, Maizel J, Mentaverri R, Chillon JM, Six I, Giummelly P, Brazier M, Choukroun G, Tribouilloy C, Massy ZA, Slama M.

Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1524-32. doi: 10.1152/ajpheart.00955.2010. Epub 2012 Jan 27.


Effects of atorvastatin on calcium-regulating proteins: a possible mechanism to repair cardiac dysfunction in spontaneously hypertensive rats.

Yao L, Chen GP, Lu X, Zheng LR, Mou Y, Hu SJ.

Basic Res Cardiol. 2009 May;104(3):258-68. doi: 10.1007/s00395-008-0751-y. Epub 2008 Oct 3.


Plasma concentration of amino-terminal pro-brain natriuretic peptide in chronic heart failure: prediction of cardiovascular events and interaction with the effects of rosuvastatin: a report from CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure).

Cleland JG, McMurray JJ, Kjekshus J, Cornel JH, Dunselman P, Fonseca C, Hjalmarson A, Korewicki J, Lindberg M, Ranjith N, van Veldhuisen DJ, Waagstein F, Wedel H, Wikstrand J; CORONA Study Group.

J Am Coll Cardiol. 2009 Nov 10;54(20):1850-9. doi: 10.1016/j.jacc.2009.06.041.


Effects of rosuvastatin correlated with the down-regulation of CYP4A1 in spontaneously hypertensive rats.

Li DB, Xu HW, Yang GJ, Yang JM, Fang H, Tang JY.

Microvasc Res. 2015 Mar;98:88-93. doi: 10.1016/j.mvr.2015.01.005. Epub 2015 Jan 28.


Effect of angiotensin converting enzyme inhibitor on the calcium transients and calcium handling proteins in ventricular myocytes from rats with heart failure.

Wang LC, Ma H, He JG, Liao XX, Chen WF, Leng XY, Ma L, Mai WY, Tao J, Zeng WT, Liu J, Dong YG, Tang AL, Feng C.

Chin Med J (Engl). 2005 May 5;118(9):731-7.


CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation.

Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, Seipelt R, Schöndube FA, Hasenfuss G, Maier LS.

Circ Res. 2010 Apr 2;106(6):1134-44. doi: 10.1161/CIRCRESAHA.109.203836. Epub 2010 Jan 7.


β-adrenergic receptor blockade reduces endoplasmic reticulum stress and normalizes calcium handling in a coronary embolization model of heart failure in canines.

George I, Sabbah HN, Xu K, Wang N, Wang J.

Cardiovasc Res. 2011 Aug 1;91(3):447-55. doi: 10.1093/cvr/cvr106. Epub 2011 Apr 14.


Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection.

Peng F, Lin J, Lin L, Tang H.

Int J Mol Med. 2012 Dec;30(6):1376-86. doi: 10.3892/ijmm.2012.1153. Epub 2012 Oct 9.


Astragalosides rescue both cardiac function and sarcoplasmic reticulum Ca²⁺ transport in rats with chronic heart failure.

Wang Y, Ji Y, Xing Y, Li X, Gao X.

Phytother Res. 2012 Feb;26(2):231-8. doi: 10.1002/ptr.3492. Epub 2011 Jun 7.


Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.

Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D.

Circulation. 2012 May 1;125(17):2059-70. doi: 10.1161/CIRCULATIONAHA.111.067306. Epub 2012 Mar 28.

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