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Items: 1 to 20 of 110


Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo.

Paden CR, Forrest JC, Tibbetts SA, Speck SH.

PLoS Pathog. 2012 Sep;8(9):e1002906. doi: 10.1371/journal.ppat.1002906. Epub 2012 Sep 6.


ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication.

Forrest JC, Paden CR, Allen RD 3rd, Collins J, Speck SH.

J Virol. 2007 Nov;81(21):11957-71. Epub 2007 Aug 15.


A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

Hellert J, Weidner-Glunde M, Krausze J, Richter U, Adler H, Fedorov R, Pietrek M, Rückert J, Ritter C, Schulz TF, Lührs T.

PLoS Pathog. 2013;9(10):e1003640. doi: 10.1371/journal.ppat.1003640. Epub 2013 Oct 17.


Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome.

Paden CR, Forrest JC, Moorman NJ, Speck SH.

J Virol. 2010 Jul;84(14):7214-24. doi: 10.1128/JVI.00133-10. Epub 2010 May 5.


Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence.

Habison AC, Beauchemin C, Simas JP, Usherwood EJ, Kaye KM.

J Virol. 2012 Nov;86(21):11863-76. doi: 10.1128/JVI.01656-12. Epub 2012 Aug 22.


Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.

Salinas E, Byrum SD, Moreland LE, Mackintosh SG, Tackett AJ, Forrest JC.

J Virol. 2015 Nov 18;90(3):1397-413. doi: 10.1128/JVI.02022-15.


Kaposi's sarcoma-associated herpesvirus-encoded LANA recruits topoisomerase IIβ for latent DNA replication of the terminal repeats.

Purushothaman P, McDowell ME, McGuinness J, Salas R, Rumjahn SM, Verma SC.

J Virol. 2012 Sep;86(18):9983-94. doi: 10.1128/JVI.00839-12. Epub 2012 Jul 3.


The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA.

Jäger W, Santag S, Weidner-Glunde M, Gellermann E, Kati S, Pietrek M, Viejo-Borbolla A, Schulz TF.

J Virol. 2012 Jun;86(12):6745-57. doi: 10.1128/JVI.06840-11. Epub 2012 Apr 18.


Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen.

Liang X, Paden CR, Morales FM, Powers RP, Jacob J, Speck SH.

PLoS Pathog. 2011 Sep;7(9):e1002220. doi: 10.1371/journal.ppat.1002220. Epub 2011 Sep 8.


A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences.

Watanabe A, Higuchi M, Fukushi M, Ohsawa T, Takahashi M, Oie M, Fujii M.

Virus Genes. 2007 Apr;34(2):127-36. Epub 2006 Dec 2.

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