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Items: 1 to 20 of 138

1.

Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles.

Emoto C, Yoda N, Uno Y, Iwasaki K, Umehara K, Kashiyama E, Yamazaki H.

Curr Drug Metab. 2013 Feb;14(2):239-52. Review.

PMID:
22963393
2.

Cynomolgus monkey CYPs: a comparison with human CYPs.

Iwasaki K, Uno Y.

Xenobiotica. 2009 Aug;39(8):578-81. doi: 10.1080/00498250903003135. Review.

PMID:
19622000
3.

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

Uehara S, Murayama N, Nakanishi Y, Zeldin DC, Yamazaki H, Uno Y.

J Pharmacol Exp Ther. 2011 Nov;339(2):654-61. doi: 10.1124/jpet.111.185009. Epub 2011 Aug 17.

4.

Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.

Yoda N, Emoto C, Date S, Kondo S, Miyake M, Nakazato S, Umehara K, Kashiyama E.

Xenobiotica. 2012 Aug;42(8):719-30. doi: 10.3109/00498254.2012.656732.

PMID:
22324396
6.

Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.

Nishimuta H, Sato K, Mizuki Y, Yabuki M, Komuro S.

Drug Metab Pharmacokinet. 2011 Jun;26(3):300-6. doi: 10.2133/dmpk.DMPK-10-SH-119. Epub 2011 Mar 4.

7.
8.

Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans.

Iwasaki K, Murayama N, Koizumi R, Uno Y, Yamazaki H.

Drug Metab Pharmacokinet. 2010;25(4):388-91.

9.

Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.

Uno Y, Uehara S, Kohara S, Murayama N, Yamazaki H.

Drug Metab Dispos. 2010 Sep;38(9):1486-92. doi: 10.1124/dmd.110.033274. Epub 2010 May 25.

10.

Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase.

Hosaka S, Murayama N, Satsukawa M, Shimizu M, Uehara S, Fujino H, Iwasaki K, Iwano S, Uno Y, Yamazaki H.

Drug Metab Dispos. 2015 Jan;43(1):27-33. doi: 10.1124/dmd.114.061275. Epub 2014 Oct 15.

11.

(+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver.

Prueksaritanont T, Dwyer LM, Cribb AE.

Biochem Pharmacol. 1995 Oct 26;50(9):1521-5.

PMID:
7503805
12.

Complementary DNA cloning and characterization of cytochrome P450 2D29 from Japanese monkey liver.

Hichiya H, Takemi C, Tsuzuki D, Yamamoto S, Asaoka K, Suzuki S, Satoh T, Shinoda S, Kataoka H, Narimatsu S.

Biochem Pharmacol. 2002 Oct 1;64(7):1101-10.

PMID:
12234613
13.

Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys.

Uehara S, Murayama N, Nakanishi Y, Nakamura C, Hashizume T, Zeldin DC, Yamazaki H, Uno Y.

Xenobiotica. 2014 Sep;44(9):769-74. doi: 10.3109/00498254.2014.895882. Epub 2014 Mar 5.

PMID:
24593267
14.

Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes.

Hanioka N, Yamamoto M, Iwabu H, Jinno H, Tanaka-Kagawa T, Naito S, Shimizu T, Masuda K, Katsu T, Narimatsu S.

Life Sci. 2007 Oct 27;81(19-20):1436-45. Epub 2007 Sep 15.

PMID:
17935737
15.

CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.

Uno Y, Fujino H, Kito G, Kamataki T, Nagata R.

Mol Pharmacol. 2006 Aug;70(2):477-86. Epub 2006 Apr 28.

16.

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey.

Uno Y, Uehara S, Kohara S, Iwasaki K, Nagata R, Fukuzaki K, Utoh M, Murayama N, Yamazaki H.

PLoS One. 2011 Feb 8;6(2):e16923. doi: 10.1371/journal.pone.0016923.

17.

Comparative study of the oxidation of propranolol enantiomers in hepatic and small intestinal microsomes from cynomolgus and marmoset monkeys.

Shimizudani T, Nagaoka K, Hanioka N, Yamano S, Narimatsu S.

Chem Biol Interact. 2010 Jan 5;183(1):67-78. doi: 10.1016/j.cbi.2009.10.007. Epub .

PMID:
19853591
18.

Diclofenac hydroxylation in monkeys: efficiency, regioselectivity, and response to inhibitors.

Tang C, Fang Y, Booth-Genthe C, Kuo Y, Kuduk SD, Rushmore TH, Carr BA.

Biochem Pharmacol. 2007 Mar 15;73(6):880-90. Epub 2006 Nov 25.

PMID:
17223083
19.

Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes.

Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH.

Biopharm Drug Dispos. 2000 Dec;21(9):353-64.

PMID:
11523064
20.

Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes.

Uno Y, Fujino H, Iwasaki K, Utoh M.

Curr Drug Metab. 2010 Feb;11(2):142-52. Review.

PMID:
20359284
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