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Genetic screening for synthetic lethal partners of polynucleotide kinase/phosphatase: potential for targeting SHP-1-depleted cancers.

Mereniuk TR, Maranchuk RA, Schindler A, Penner-Chea J, Freschauf GK, Hegazy S, Lai R, Foley E, Weinfeld M.

Cancer Res. 2012 Nov 15;72(22):5934-44. doi: 10.1158/0008-5472.CAN-12-0939. Epub 2012 Sep 7.


Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase.

Mereniuk TR, El Gendy MA, Mendes-Pereira AM, Lord CJ, Ghosh S, Foley E, Ashworth A, Weinfeld M.

Mol Cancer Ther. 2013 Oct;12(10):2135-44. doi: 10.1158/1535-7163.MCT-12-1093. Epub 2013 Jul 24.


Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.

Freschauf GK, Mani RS, Mereniuk TR, Fanta M, Virgen CA, Dianov GL, Grassot JM, Hall DG, Weinfeld M.

J Biol Chem. 2010 Jan 22;285(4):2351-60. doi: 10.1074/jbc.M109.055764. Epub 2009 Nov 23.


Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.

Mandal SM, Hegde ML, Chatterjee A, Hegde PM, Szczesny B, Banerjee D, Boldogh I, Gao R, Falkenberg M, Gustafsson CM, Sarkar PS, Hazra TK.

J Biol Chem. 2012 Jan 20;287(4):2819-29. doi: 10.1074/jbc.M111.272179. Epub 2011 Nov 30.


Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.

Freschauf GK, Karimi-Busheri F, Ulaczyk-Lesanko A, Mereniuk TR, Ahrens A, Koshy JM, Rasouli-Nia A, Pasarj P, Holmes CF, Rininsland F, Hall DG, Weinfeld M.

Cancer Res. 2009 Oct 1;69(19):7739-46. doi: 10.1158/0008-5472.CAN-09-1805. Epub 2009 Sep 22.


Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair.

Reynolds JJ, Walker AK, Gilmore EC, Walsh CA, Caldecott KW.

Nucleic Acids Res. 2012 Aug;40(14):6608-19. doi: 10.1093/nar/gks318. Epub 2012 Apr 15.


Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

Weinfeld M, Mani RS, Abdou I, Aceytuno RD, Glover JN.

Trends Biochem Sci. 2011 May;36(5):262-71. doi: 10.1016/j.tibs.2011.01.006. Epub 2011 Feb 25. Review.


Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1.

Lu M, Mani RS, Karimi-Busheri F, Fanta M, Wang H, Litchfeld DW, Weinfeld M.

Nucleic Acids Res. 2010 Jan;38(2):510-21. doi: 10.1093/nar/gkp1023. Epub 2009 Nov 12.


Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.

Rodríguez-Ubreva FJ, Cariaga-Martinez AE, Cortés MA, Romero-De Pablos M, Ropero S, López-Ruiz P, Colás B.

Oncogene. 2010 Jan 21;29(3):345-55. doi: 10.1038/onc.2009.329. Epub 2009 Oct 19.


Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability.

Shimada M, Dumitrache LC, Russell HR, McKinnon PJ.

EMBO J. 2015 Oct 1;34(19):2465-80. doi: 10.15252/embj.201591363. Epub 2015 Aug 19.


SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases.

Wu C, Guan Q, Wang Y, Zhao ZJ, Zhou GW.

J Cell Biochem. 2003 Dec 1;90(5):1026-37.


The function of the protein tyrosine phosphatase SHP-1 in cancer.

Wu C, Sun M, Liu L, Zhou GW.

Gene. 2003 Mar 13;306:1-12. Review.


The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation.

Lee JH, Yeon JH, Kim H, Roh W, Chae J, Park HO, Kim DM.

PLoS One. 2012;7(9):e45023. doi: 10.1371/journal.pone.0045023. Epub 2012 Sep 13.


STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6948-53. Epub 2005 May 3.


Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair.

Tahbaz N, Subedi S, Weinfeld M.

Nucleic Acids Res. 2012 Apr;40(8):3484-95. doi: 10.1093/nar/gkr1245. Epub 2011 Dec 30.


Abnormal splicing of SHP-1 protein tyrosine phosphatase in human T cells. Implications for lymphomagenesis.

Ma XZ, Jin T, Sakac D, Fahim S, Zhang X, Katsman Y, Bali M, Branch DR.

Exp Hematol. 2003 Feb;31(2):131-42.


A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.

Lord CJ, McDonald S, Swift S, Turner NC, Ashworth A.

DNA Repair (Amst). 2008 Dec 1;7(12):2010-9. doi: 10.1016/j.dnarep.2008.08.014. Epub 2008 Oct 15.


Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.

Montano X.

Oncogene. 2009 Oct 29;28(43):3787-800. doi: 10.1038/onc.2009.143. Epub 2009 Sep 14.


[Inhibitory effect of SHP-1 gene transfer on the proliferation of breast cancer cell line MDA-MB-231].

Xie YL, Liang JZ, Liu FY, Zhang JY, Xie JM, Luo RC, Li R.

Nan Fang Yi Ke Da Xue Xue Bao. 2010 May;30(5):1024-7. Chinese.

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