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Items: 1 to 20 of 117


The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines.

Lucero CM, Vega OA, Osorio MM, Tapia JC, Antonelli M, Stein GS, van Wijnen AJ, Galindo MA.

J Cell Physiol. 2013 Apr;228(4):714-23. doi: 10.1002/jcp.24218.


Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells.

San Martin IA, Varela N, Gaete M, Villegas K, Osorio M, Tapia JC, Antonelli M, Mancilla EE, Pereira BP, Nathan SS, Lian JB, Stein JL, Stein GS, van Wijnen AJ, Galindo M.

J Cell Physiol. 2009 Dec;221(3):560-71. doi: 10.1002/jcp.21894.


MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma.

van der Deen M, Taipaleenmäki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ.

J Biol Chem. 2013 Jul 19;288(29):21307-19. doi: 10.1074/jbc.M112.445890. Epub 2013 May 29.


Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma.

Thomas DM, Johnson SA, Sims NA, Trivett MK, Slavin JL, Rubin BP, Waring P, McArthur GA, Walkley CR, Holloway AJ, Diyagama D, Grim JE, Clurman BE, Bowtell DD, Lee JS, Gutierrez GM, Piscopo DM, Carty SA, Hinds PW.

J Cell Biol. 2004 Dec 6;167(5):925-34.


The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts.

Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ.

J Biol Chem. 2005 May 27;280(21):20274-85. Epub 2005 Mar 21.


Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.

Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan RI.

Cancer Res. 2010 Jul 1;70(13):5577-86. doi: 10.1158/0008-5472.CAN-09-4602. Epub 2010 Jun 8.


Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).

Pereira BP, Zhou Y, Gupta A, Leong DT, Aung KZ, Ling L, Pho RW, Galindo M, Salto-Tellez M, Stein GS, Cool SM, van Wijnen AJ, Nathan SS.

J Cell Physiol. 2009 Dec;221(3):778-88. doi: 10.1002/jcp.21921.


Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility.

van der Deen M, Akech J, Lapointe D, Gupta S, Young DW, Montecino MA, Galindo M, Lian JB, Stein JL, Stein GS, van Wijnen AJ.

J Biol Chem. 2012 Feb 10;287(7):4503-17. doi: 10.1074/jbc.M111.287771. Epub 2011 Dec 9.


RUNX2 expression in developing human bones and various bone tumors.

Sugawara M, Kato N, Tsuchiya T, Motoyama T.

Pathol Int. 2011 Oct;61(10):565-71. doi: 10.1111/j.1440-1827.2011.02706.x. Epub 2011 Aug 9.


Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells.

Sung JY, Park SY, Kim JH, Kang HG, Yoon JH, Na YS, Kim YN, Park BK.

Cell Death Dis. 2014 May 15;5:e1224. doi: 10.1038/cddis.2014.189.


Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation.

Bodo M, Lilli C, Bellucci C, Carinci P, Calvitti M, Pezzetti F, Stabellini G, Bellocchio S, Balducci C, Carinci F, Baroni T.

Mol Med. 2002 Jul;8(7):393-404.


Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma.

Nathan SS, Pereira BP, Zhou YF, Gupta A, Dombrowski C, Soong R, Pho RW, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ.

Mol Biol Rep. 2009 Jan;36(1):153-8. doi: 10.1007/s11033-008-9378-1. Epub 2008 Oct 18.


Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.

Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A.

J Biol Chem. 2006 Mar 17;281(11):7118-28. Epub 2006 Jan 9.


RUNX2 and Osteosarcoma.

Li N, Luo D, Hu X, Luo W, Lei G, Wang Q, Zhu T, Gu J, Lu Y, Zheng Q.

Anticancer Agents Med Chem. 2015;15(7):881-7. Review.


Developmental pathways hijacked by osteosarcoma.

Mortus JR, Zhang Y, Hughes DP.

Adv Exp Med Biol. 2014;804:93-118. doi: 10.1007/978-3-319-04843-7_5. Review.


Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma.

Su Y, Wagner ER, Luo Q, Huang J, Chen L, He BC, Zuo GW, Shi Q, Zhang BQ, Zhu G, Bi Y, Luo J, Luo X, Kim SH, Shen J, Rastegar F, Huang E, Gao Y, Gao JL, Yang K, Wietholt C, Li M, Qin J, Haydon RC, He TC, Luu HH.

Oncogene. 2011 Sep 15;30(37):3907-17. doi: 10.1038/onc.2011.97. Epub 2011 Apr 4.


MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma.

Zhang K, Tian F, Zhang Y, Zhu Q, Xue N, Zhu H, Wang H, Guo X.

Tumour Biol. 2014 Mar;35(3):2537-48. doi: 10.1007/s13277-013-1335-5. Epub 2013 Oct 27.


Ascorbic acid induces either differentiation or apoptosis in MG-63 osteosarcoma lineage.

Valenti MT, Zanatta M, Donatelli L, Viviano G, Cavallini C, Scupoli MT, Dalle Carbonare L.

Anticancer Res. 2014 Apr;34(4):1617-27.


Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma.

Yang J, Zhao L, Tian W, Liao Z, Zheng H, Wang G, Chen K.

BMC Med Genomics. 2013 Dec 15;6:56. doi: 10.1186/1755-8794-6-56.


Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway.

Hsu YL, Huang MS, Yang CJ, Hung JY, Wu LY, Kuo PL.

J Biol Chem. 2011 Oct 28;286(43):37335-46. doi: 10.1074/jbc.M111.256156. Epub 2011 Sep 1.

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