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The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein.

Guan D, Factor D, Liu Y, Wang Z, Kao HY.

Oncogene. 2013 Aug 15;32(33):3819-28. doi: 10.1038/onc.2012.406. Epub 2012 Sep 3. Erratum in: Oncogene. 2015 Oct 1;34(40):5206.


Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor α (TNFα) and interferon α (IFNα).

Cheng X, Liu Y, Chu H, Kao HY.

J Biol Chem. 2012 Jul 6;287(28):23356-67. doi: 10.1074/jbc.M112.340505. Epub 2012 May 15.


UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.

Zhou L, Shang Y, Jin Z, Zhang W, Lv C, Zhao X, Liu Y, Li N, Liang J.

Cancer Biol Ther. 2015;16(8):1241-51. doi: 10.1080/15384047.2015.1056411. Epub 2015 Jul 6.


Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1).

Dai C, Shi D, Gu W.

J Biol Chem. 2013 Jul 5;288(27):19581-92. doi: 10.1074/jbc.M113.476606. Epub 2013 May 15.


Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma.

Ma J, Peng J, Mo R, Ma S, Wang J, Zang L, Li W, Fan J.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):147-53. doi: 10.1016/j.bbrc.2015.06.104. Epub 2015 Jun 20.


Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies.

Geoffroy MC, Jaffray EG, Walker KJ, Hay RT.

Mol Biol Cell. 2010 Dec;21(23):4227-39. doi: 10.1091/mbc.E10-05-0449. Epub 2010 Oct 13.


KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.

Chen HY, Hu JY, Chen TH, Lin YC, Liu X, Lin MY, Lang YD, Yen Y, Chen RH.

Oncogene. 2015 Oct 1;34(40):5141-51. doi: 10.1038/onc.2014.435. Epub 2015 Jan 26.


Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation.

Gao C, Ho CC, Reineke E, Lam M, Cheng X, Stanya KJ, Liu Y, Chakraborty S, Shih HM, Kao HY.

Mol Cell Biol. 2008 Sep;28(18):5658-67. doi: 10.1128/MCB.00874-08. Epub 2008 Jul 14.


Epigenetic repression of regulator of G-protein signaling 2 by ubiquitin-like with PHD and ring-finger domain 1 promotes bladder cancer progression.

Ying L, Lin J, Qiu F, Cao M, Chen H, Liu Z, Huang Y.

FEBS J. 2015 Jan;282(1):174-82. doi: 10.1111/febs.13116. Epub 2014 Dec 3.


The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.

Rabellino A, Carter B, Konstantinidou G, Wu SY, Rimessi A, Byers LA, Heymach JV, Girard L, Chiang CM, Teruya-Feldstein J, Scaglioni PP.

Cancer Res. 2012 May 1;72(9):2275-84. doi: 10.1158/0008-5472.CAN-11-3159. Epub 2012 Mar 9.


β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.

Satow R, Shitashige M, Jigami T, Fukami K, Honda K, Kitabayashi I, Yamada T.

Gastroenterology. 2012 Mar;142(3):572-81. doi: 10.1053/j.gastro.2011.11.041. Epub 2011 Dec 9.


AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.

Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC.

Oncogene. 2011 Mar 10;30(10):1194-204. doi: 10.1038/onc.2010.499. Epub 2010 Nov 8.


E6AP promotes the degradation of the PML tumor suppressor.

Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y.

Cell Death Differ. 2009 Aug;16(8):1156-66. doi: 10.1038/cdd.2009.31. Epub 2009 Mar 27.


Role of SUMO in RNF4-mediated promyelocytic leukemia protein (PML) degradation: sumoylation of PML and phospho-switch control of its SUMO binding domain dissected in living cells.

Percherancier Y, Germain-Desprez D, Galisson F, Mascle XH, Dianoux L, Estephan P, Chelbi-Alix MK, Aubry M.

J Biol Chem. 2009 Jun 12;284(24):16595-608. doi: 10.1074/jbc.M109.006387. Epub 2009 Apr 20.


Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.

Liang C, Zhang X, Song S, Tian C, Yin Y, Xing G, He F, Zhang L.

Biochem Biophys Res Commun. 2013 Apr 19;433(4):415-9. doi: 10.1016/j.bbrc.2013.02.126. Epub 2013 Mar 26.


Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover.

Lim JH, Liu Y, Reineke E, Kao HY.

J Biol Chem. 2011 Dec 30;286(52):44403-11. doi: 10.1074/jbc.M111.289512. Epub 2011 Oct 27.


The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.

Fanelli M, Fantozzi A, De Luca P, Caprodossi S, Matsuzawa S, Lazar MA, Pelicci PG, Minucci S.

J Biol Chem. 2004 Feb 13;279(7):5374-9. Epub 2003 Nov 25.


Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death.

Guan D, Lim JH, Peng L, Liu Y, Lam M, Seto E, Kao HY.

Cell Death Dis. 2014 Jul 17;5:e1340. doi: 10.1038/cddis.2014.185.


The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.

Babbio F, Pistore C, Curti L, Castiglioni I, Kunderfranco P, Brino L, Oudet P, Seiler R, Thalman GN, Roggero E, Sarti M, Pinton S, Mello-Grand M, Chiorino G, Catapano CV, Carbone GM, Bonapace IM.

Oncogene. 2012 Nov 15;31(46):4878-87. doi: 10.1038/onc.2011.641. Epub 2012 Feb 13.


UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer.

Jin W, Chen L, Chen Y, Xu SG, Di GH, Yin WJ, Wu J, Shao ZM.

Breast Cancer Res Treat. 2010 Sep;123(2):359-73. doi: 10.1007/s10549-009-0652-2. Epub 2009 Nov 27.

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