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Items: 1 to 20 of 103

1.

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A, Ramasamy G, Vainio S, Heidebrecht T, Perrakis A, Pagie L, van Steensel B, Myler PJ, Borst P.

Cell. 2012 Aug 31;150(5):909-21. doi: 10.1016/j.cell.2012.07.030.

2.

Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma brucei.

Reynolds D, Cliffe L, Förstner KU, Hon CC, Siegel TN, Sabatini R.

Nucleic Acids Res. 2014 Sep;42(15):9717-29. doi: 10.1093/nar/gku714. Epub 2014 Aug 7.

3.

Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing.

Genest PA, Baugh L, Taipale A, Zhao W, Jan S, van Luenen HG, Korlach J, Clark T, Luong K, Boitano M, Turner S, Myler PJ, Borst P.

Nucleic Acids Res. 2015 Feb 27;43(4):2102-15. doi: 10.1093/nar/gkv095. Epub 2015 Feb 6.

4.

Transcription: base J blocks the way.

Hazelbaker DZ, Buratowski S.

Curr Biol. 2012 Nov 20;22(22):R960-2. doi: 10.1016/j.cub.2012.10.010.

5.

Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.

Cliffe LJ, Siegel TN, Marshall M, Cross GA, Sabatini R.

Nucleic Acids Res. 2010 Jul;38(12):3923-35. doi: 10.1093/nar/gkq146. Epub 2010 Mar 9.

6.

Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

van Leeuwen F, Kieft R, Cross M, Borst P.

Mol Cell Biol. 1998 Oct;18(10):5643-51.

7.

The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase.

Yu Z, Genest PA, ter Riet B, Sweeney K, DiPaolo C, Kieft R, Christodoulou E, Perrakis A, Simmons JM, Hausinger RP, van Luenen HG, Rigden DJ, Sabatini R, Borst P.

Nucleic Acids Res. 2007;35(7):2107-15. Epub 2007 Mar 27.

8.

Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J.

Vainio S, Genest PA, ter Riet B, van Luenen H, Borst P.

Mol Biochem Parasitol. 2009 Apr;164(2):157-61. doi: 10.1016/j.molbiopara.2008.12.001. Epub 2008 Dec 9.

PMID:
19114062
9.

Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding.

Heidebrecht T, Fish A, von Castelmur E, Johnson KA, Zaccai G, Borst P, Perrakis A.

J Am Chem Soc. 2012 Aug 15;134(32):13357-65. doi: 10.1021/ja303423t. Epub 2012 Jul 31.

PMID:
22775585
10.

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei.

Reynolds D, Hofmeister BT, Cliffe L, Alabady M, Siegel TN, Schmitz RJ, Sabatini R.

PLoS Genet. 2016 Jan 21;12(1):e1005758. doi: 10.1371/journal.pgen.1005758. eCollection 2016 Jan.

11.

JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes.

Cliffe LJ, Kieft R, Southern T, Birkeland SR, Marshall M, Sweeney K, Sabatini R.

Nucleic Acids Res. 2009 Apr;37(5):1452-62. doi: 10.1093/nar/gkn1067. Epub 2009 Jan 9.

12.

Quantitative mass spectrometry-based analysis of β-D-glucosyl-5-hydroxymethyluracil in genomic DNA of Trypanosoma brucei.

Liu S, Ji D, Cliffe L, Sabatini R, Wang Y.

J Am Soc Mass Spectrom. 2014 Oct;25(10):1763-70. doi: 10.1007/s13361-014-0960-6. Epub 2014 Jul 31.

13.

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei.

Kieft R, Brand V, Ekanayake DK, Sweeney K, DiPaolo C, Reznikoff WS, Sabatini R.

Mol Biochem Parasitol. 2007 Nov;156(1):24-31. Epub 2007 Jun 28.

15.

Identification of the glucosyltransferase that converts hydroxymethyluracil to base J in the trypanosomatid genome.

Bullard W, Lopes da Rosa-Spiegler J, Liu S, Wang Y, Sabatini R.

J Biol Chem. 2014 Jul 18;289(29):20273-82. doi: 10.1074/jbc.M114.579821. Epub 2014 Jun 2.

16.

Base J: discovery, biosynthesis, and possible functions.

Borst P, Sabatini R.

Annu Rev Microbiol. 2008;62:235-51. doi: 10.1146/annurev.micro.62.081307.162750. Review.

PMID:
18729733
17.

beta-D-glucosyl-hydroxymethyluracil, a novel base in African trypanosomes and other Kinetoplastida.

Borst P, van Leeuwen F.

Mol Biochem Parasitol. 1997 Dec 1;90(1):1-8. Review.

PMID:
9497027
18.

Telomeric localization of the modified DNA base J in the genome of the protozoan parasite Leishmania.

Genest PA, Ter Riet B, Cijsouw T, van Luenen HG, Borst P.

Nucleic Acids Res. 2007;35(7):2116-24. Epub 2007 Feb 28.

19.

The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans.

Cross M, Kieft R, Sabatini R, Wilm M, de Kort M, van der Marel GA, van Boom JH, van Leeuwen F, Borst P.

EMBO J. 1999 Nov 15;18(22):6573-81.

20.

Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

van Leeuwen F, Kieft R, Cross M, Borst P.

Mol Biochem Parasitol. 2000 Jul;109(2):133-45.

PMID:
10960172
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