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Efficient glycosylphosphatidylinositol (GPI) modification of membrane proteins requires a C-terminal anchoring signal of marginal hydrophobicity.

Galian C, Björkholm P, Bulleid N, von Heijne G.

J Biol Chem. 2012 May 11;287(20):16399-409. doi: 10.1074/jbc.M112.350009. Epub 2012 Mar 19.


Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins.

Ohishi K, Inoue N, Maeda Y, Takeda J, Riezman H, Kinoshita T.

Mol Biol Cell. 2000 May;11(5):1523-33.


A constitutive role for GPI anchors in Saccharomyces cerevisiae: cell wall targeting.

De Sampaïo G, Bourdineaud JP, Lauquin GJ.

Mol Microbiol. 1999 Oct;34(2):247-56.


MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.

Gaynor EC, Mondésert G, Grimme SJ, Reed SI, Orlean P, Emr SD.

Mol Biol Cell. 1999 Mar;10(3):627-48.


Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.

McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S.

ACS Chem Biol. 2012 Sep 21;7(9):1520-8. Epub 2012 Jun 22.


Activation mechanism, functional role and shedding of glycosylphosphatidylinositol-anchored Yps1p at the Saccharomyces cerevisiae cell surface.

Gagnon-Arsenault I, Parisé L, Tremblay J, Bourbonnais Y.

Mol Microbiol. 2008 Aug;69(4):982-93. doi: 10.1111/j.1365-2958.2008.06339.x. Epub 2008 Jun 28.


Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.

Hamburger D, Egerton M, Riezman H.

J Cell Biol. 1995 May;129(3):629-39.


Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.

Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T.

Mol Biol Cell. 2003 May;14(5):1780-9. Epub 2003 Jan 26.


GPI-anchor remodeling: potential functions of GPI-anchors in intracellular trafficking and membrane dynamics.

Fujita M, Kinoshita T.

Biochim Biophys Acta. 2012 Aug;1821(8):1050-8. doi: 10.1016/j.bbalip.2012.01.004. Epub 2012 Jan 11. Review.


Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.

Umemura M, Fujita M, Yoko-O T, Fukamizu A, Jigami Y.

Mol Biol Cell. 2007 Nov;18(11):4304-16. Epub 2007 Aug 29.


N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase.

Dubé AK, Bélanger M, Gagnon-Arsenault I, Bourbonnais Y.

BMC Microbiol. 2015 Feb 26;15:50. doi: 10.1186/s12866-015-0380-1.


Yeast Gpi8p is essential for GPI anchor attachment onto proteins.

Benghezal M, Benachour A, Rusconi S, Aebi M, Conzelmann A.

EMBO J. 1996 Dec 2;15(23):6575-83.

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