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Results: 1 to 20 of 106

1.

The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.

Thompson R, Montano R, Eastman A.

PLoS One. 2012;7(8):e44021. doi: 10.1371/journal.pone.0044021. Epub 2012 Aug 24.

PMID:
22937147
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.

Limbo O, Porter-Goff ME, Rhind N, Russell P.

Mol Cell Biol. 2011 Feb;31(3):573-83. doi: 10.1128/MCB.00994-10. Epub 2010 Nov 22.

PMID:
21098122
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.

Lee J, Dunphy WG.

Mol Biol Cell. 2013 May;24(9):1343-53. doi: 10.1091/mbc.E13-01-0025. Epub 2013 Mar 6.

PMID:
23468519
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.

Montano R, Chung I, Garner KM, Parry D, Eastman A.

Mol Cancer Ther. 2012 Feb;11(2):427-38. doi: 10.1158/1535-7163.MCT-11-0406. Epub 2011 Dec 27.

PMID:
22203733
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.

PMID:
16905549
[PubMed - indexed for MEDLINE]
Free Article
6.

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase.

McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, Schwartz G, Tse A.

Cell Cycle. 2010 Mar 1;9(5):995-1004. Epub 2010 Mar 14.

PMID:
20160494
[PubMed - indexed for MEDLINE]
Free Article
7.

Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.

Forment JV, Blasius M, Guerini I, Jackson SP.

PLoS One. 2011;6(8):e23517. doi: 10.1371/journal.pone.0023517. Epub 2011 Aug 17.

PMID:
21858151
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock.

Seno JD, Dynlacht JR.

J Cell Physiol. 2004 May;199(2):157-70.

PMID:
15039997
[PubMed - indexed for MEDLINE]
9.

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.

Yu Z, Vogel G, Coulombe Y, Dubeau D, Spehalski E, H├ębert J, Ferguson DO, Masson JY, Richard S.

Cell Res. 2012 Feb;22(2):305-20. doi: 10.1038/cr.2011.128. Epub 2011 Aug 9.

PMID:
21826105
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.

PMID:
19060337
[PubMed - indexed for MEDLINE]
Free Article
11.

ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.

Ewald B, Sampath D, Plunkett W.

Cancer Res. 2008 Oct 1;68(19):7947-55. doi: 10.1158/0008-5472.CAN-08-0971.

PMID:
18829552
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.

Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K.

Cell Cycle. 2010 Jul 15;9(14):2866-77. Epub 2010 Jul 12.

PMID:
20647759
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.

Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.

Cell Cycle. 2011 Jul 1;10(13):2218-32. Epub 2011 Jul 1.

PMID:
21623170
[PubMed - indexed for MEDLINE]
Free Article
14.

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.

Wen Q, Scorah J, Phear G, Rodgers G, Rodgers S, Meuth M.

Mol Biol Cell. 2008 Apr;19(4):1693-705. doi: 10.1091/mbc.E07-09-0975. Epub 2008 Feb 6.

PMID:
18256278
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

Nakada D, Hirano Y, Sugimoto K.

Mol Cell Biol. 2004 Nov;24(22):10016-25.

PMID:
15509802
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair.

Dmitrieva NI, Bulavin DV, Burg MB.

Am J Physiol Renal Physiol. 2003 Aug;285(2):F266-74. Epub 2003 Apr 8.

PMID:
12684226
[PubMed - indexed for MEDLINE]
Free Article
17.

Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation.

Davies KD, Cable PL, Garrus JE, Sullivan FX, von Carlowitz I, Huerou YL, Wallace E, Woessner RD, Gross S.

Cancer Biol Ther. 2011 Nov 1;12(9):788-96. doi: 10.4161/cbt.12.9.17673. Epub 2011 Nov 1.

PMID:
21892012
[PubMed - indexed for MEDLINE]
Free Article
18.

Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.

Guzi TJ, Paruch K, Dwyer MP, Labroli M, Shanahan F, Davis N, Taricani L, Wiswell D, Seghezzi W, Penaflor E, Bhagwat B, Wang W, Gu D, Hsieh Y, Lee S, Liu M, Parry D.

Mol Cancer Ther. 2011 Apr;10(4):591-602. doi: 10.1158/1535-7163.MCT-10-0928. Epub 2011 Feb 14.

PMID:
21321066
[PubMed - indexed for MEDLINE]
Free Article
19.

PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin.

Di Virgilio M, Ying CY, Gautier J.

DNA Repair (Amst). 2009 Nov 2;8(11):1311-20. doi: 10.1016/j.dnarep.2009.07.006. Epub 2009 Aug 25.

PMID:
19709933
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation.

Kobayashi J, Kato A, Ota Y, Ohba R, Komatsu K.

Mol Cancer. 2010 Feb 9;9:34. doi: 10.1186/1476-4598-9-34.

PMID:
20144237
[PubMed - indexed for MEDLINE]
Free PMC Article

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