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Results: 1 to 20 of 105

1.

Classification of active and weakly active ST inhibitors of HIV-1 integrase using a support vector machine.

Yan A, Xuan S, Hu X.

Comb Chem High Throughput Screen. 2012 Dec;15(10):792-805.

PMID:
22934952
[PubMed - indexed for MEDLINE]
2.

Prediction of bioactivity of HIV-1 integrase ST inhibitors by multilinear regression analysis and support vector machine.

Xuan S, Wu Y, Chen X, Liu J, Yan A.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1648-55. doi: 10.1016/j.bmcl.2013.01.081. Epub 2013 Jan 27.

PMID:
23395655
[PubMed - indexed for MEDLINE]
3.

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.

Melamed JY, Egbertson MS, Varga S, Vacca JP, Moyer G, Gabryelski L, Felock PJ, Stillmock KA, Witmer MV, Schleif W, Hazuda DJ, Leonard Y, Jin L, Ellis JD, Young SD.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5307-10. doi: 10.1016/j.bmcl.2008.08.038. Epub 2008 Aug 14.

PMID:
18774711
[PubMed - indexed for MEDLINE]
4.

Design and synthesis of novel β-diketo derivatives as HIV-1 integrase inhibitors.

Hu L, Zhang S, He X, Luo Z, Wang X, Liu W, Qin X.

Bioorg Med Chem. 2012 Jan 1;20(1):177-82. doi: 10.1016/j.bmc.2011.11.014. Epub 2011 Nov 22.

PMID:
22154762
[PubMed - indexed for MEDLINE]
5.

Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.

Di Santo R, Costi R, Roux A, Miele G, Crucitti GC, Iacovo A, Rosi F, Lavecchia A, Marinelli L, Di Giovanni C, Novellino E, Palmisano L, Andreotti M, Amici R, Galluzzo CM, Nencioni L, Palamara AT, Pommier Y, Marchand C.

J Med Chem. 2008 Aug 14;51(15):4744-50. doi: 10.1021/jm8001422. Epub 2008 Jul 23.

PMID:
18646746
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Hazuda DJ, Anthony NJ, Gomez RP, Jolly SM, Wai JS, Zhuang L, Fisher TE, Embrey M, Guare JP Jr, Egbertson MS, Vacca JP, Huff JR, Felock PJ, Witmer MV, Stillmock KA, Danovich R, Grobler J, Miller MD, Espeseth AS, Jin L, Chen IW, Lin JH, Kassahun K, Ellis JD, Wong BK, Xu W, Pearson PG, Schleif WA, Cortese R, Emini E, Summa V, Holloway MK, Young SD.

Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11233-8. Epub 2004 Jul 26.

PMID:
15277684
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.

Walker MA, Johnson T, Ma Z, Banville J, Remillard R, Kim O, Zhang Y, Staab A, Wong H, Torri A, Samanta H, Lin Z, Deminie C, Terry B, Krystal M, Meanwell N.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2920-4. Epub 2006 Mar 20.

PMID:
16546383
[PubMed - indexed for MEDLINE]
8.

Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.

Yang L, Xu X, Huang Y, Zhang B, Zeng C, He H, Wang C, Hu L.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5469-71. doi: 10.1016/j.bmcl.2010.07.087. Epub 2010 Jul 25.

PMID:
20709544
[PubMed - indexed for MEDLINE]
9.

Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.

Patil S, Kamath S, Sanchez T, Neamati N, Schinazi RF, Buolamwini JK.

Bioorg Med Chem. 2007 Feb 1;15(3):1212-28. Epub 2006 Nov 16.

PMID:
17158051
[PubMed - indexed for MEDLINE]
10.

Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.

Ma K, Wang P, Fu W, Wan X, Zhou L, Chu Y, Ye D.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6724-7. doi: 10.1016/j.bmcl.2011.09.054. Epub 2011 Sep 20.

PMID:
21996518
[PubMed - indexed for MEDLINE]
11.

Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.

Sechi M, Derudas M, Dallocchio R, Dessì A, Bacchi A, Sannia L, Carta F, Palomba M, Ragab O, Chan C, Shoemaker R, Sei S, Dayam R, Neamati N.

J Med Chem. 2004 Oct 7;47(21):5298-310.

PMID:
15456274
[PubMed - indexed for MEDLINE]
12.

Probing a chemical space for fragmental topology-activity landscapes (FRAGTAL): application for diketo acid and catechol HIV integrase inhibitor offspring fragments.

Bak A, Magdziarz T, Kurczyk A, Serafin K, Polanski J.

Comb Chem High Throughput Screen. 2013 May;16(4):274-87.

PMID:
23330876
[PubMed - indexed for MEDLINE]
13.

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.

Sharma H, Patil S, Sanchez TW, Neamati N, Schinazi RF, Buolamwini JK.

Bioorg Med Chem. 2011 Mar 15;19(6):2030-45. doi: 10.1016/j.bmc.2011.01.047. Epub 2011 Mar 1.

PMID:
21371895
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Design of novel bioisosteres of beta-diketo acid inhibitors of HIV-1 integrase.

Sechi M, Sannia L, Carta F, Palomba M, Dallocchio R, Dessì A, Derudas M, Zawahir Z, Neamati N.

Antivir Chem Chemother. 2005;16(1):41-61.

PMID:
15739621
[PubMed - indexed for MEDLINE]
15.

Correlation of biological activity with active site binding modes of geminal disulfone HIV-1 integrase inhibitors.

Meadows DC, Tantillo DJ, Gervay-Hague J.

ChemMedChem. 2006 Sep;1(9):959-64. Review. No abstract available.

PMID:
16952140
[PubMed - indexed for MEDLINE]
16.

QSAR study of carboxylic acid derivatives as HIV-1 Integrase inhibitors.

Cheng Z, Zhang Y, Fu W.

Eur J Med Chem. 2010 Sep;45(9):3970-80. doi: 10.1016/j.ejmech.2010.05.052. Epub 2010 Jun 1.

PMID:
20561721
[PubMed - indexed for MEDLINE]
17.

Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.

Di Santo R, Costi R, Roux A, Artico M, Lavecchia A, Marinelli L, Novellino E, Palmisano L, Andreotti M, Amici R, Galluzzo CM, Nencioni L, Palamara AT, Pommier Y, Marchand C.

J Med Chem. 2006 Mar 23;49(6):1939-45.

PMID:
16539381
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A platform for designing HIV integrase inhibitors. Part 1: 2-hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores.

Kawasuji T, Yoshinaga T, Sato A, Yodo M, Fujiwara T, Kiyama R.

Bioorg Med Chem. 2006 Dec 15;14(24):8430-45. Epub 2006 Sep 28.

PMID:
17010623
[PubMed - indexed for MEDLINE]
19.

Ethyl malonate amides: a diketo acid offspring fragment for HIV integrase inhibition.

Serafin K, Mazur P, Bak A, Laine E, Tchertanov L, Mouscadet JF, Polanski J.

Bioorg Med Chem. 2011 Aug 15;19(16):5000-5. doi: 10.1016/j.bmc.2011.06.054. Epub 2011 Jun 29.

PMID:
21767953
[PubMed - indexed for MEDLINE]
20.

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Bioorg Med Chem Lett. 2011 May 15;21(10):2986-90. doi: 10.1016/j.bmcl.2011.03.047. Epub 2011 Mar 21.

PMID:
21493066
[PubMed - indexed for MEDLINE]
Free PMC Article

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