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Items: 1 to 20 of 121

1.

Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels.

Schilling D, Düwel M, Molls M, Multhoff G.

Cell Stress Chaperones. 2013 Mar;18(2):183-91. doi: 10.1007/s12192-012-0369-8. Epub 2012 Aug 30.

2.

Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence.

Luo H, Yount C, Lang H, Yang A, Riemer EC, Lyons K, Vanek KN, Silvestri GA, Schulte BA, Wang GY.

Lung Cancer. 2013 Aug;81(2):167-73. doi: 10.1016/j.lungcan.2013.04.017. Epub 2013 May 16.

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Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo.

Lai CY, Tsai AC, Chen MC, Chang LH, Sun HL, Chang YL, Chen CC, Teng CM, Pan SL.

PLoS One. 2012;7(8):e42192. doi: 10.1371/journal.pone.0042192. Epub 2012 Aug 13.

6.

LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression.

Liu W, Dai Q, Lu N, Wei L, Ha J, Rong J, Mu R, You Q, Li Z, Guo Q.

Biochem Cell Biol. 2011 Jun;89(3):287-98. doi: 10.1139/O10-162. Epub 2011 Apr 14.

PMID:
21491996
7.

Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3.

Du W, Wu J, Walsh EM, Zhang Y, Chen CY, Xiao ZX.

J Biol Chem. 2009 Sep 25;284(39):26315-21. doi: 10.1074/jbc.M109.046904. Epub 2009 Jul 31.

8.

Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells.

Duan W, Gao L, Wu X, Zhang Y, Otterson GA, Villalona-Calero MA.

Exp Cell Res. 2006 Oct 15;312(17):3370-8. Epub 2006 Jul 21.

PMID:
16934800
9.

Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression.

Sachweh MC, Drummond CJ, Higgins M, Campbell J, Laín S.

Cell Death Dis. 2013 Mar 7;4:e533. doi: 10.1038/cddis.2013.61.

10.

Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction.

Zhang L, Zhang J, Hu C, Cao J, Zhou X, Hu Y, He Q, Yang B.

Anticancer Drugs. 2009 Jul;20(6):416-24.

PMID:
19579266
11.

Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2.

Cao C, Shinohara ET, Subhawong TK, Geng L, Kim KW, Albert JM, Hallahan DE, Lu B.

Mol Cancer Ther. 2006 Feb;5(2):411-7.

12.

Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway.

Koster R, Timmer-Bosscha H, Bischoff R, Gietema JA, de Jong S.

Cell Death Dis. 2011 Apr 21;2:e148. doi: 10.1038/cddis.2011.33.

13.

IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells.

Zuo S, Liu C, Wang J, Wang F, Xu W, Cui S, Yuan L, Chen X, Fan W, Cui M, Song G.

J Cancer Res Clin Oncol. 2012 Jun;138(6):1045-55. doi: 10.1007/s00432-012-1153-y. Epub 2012 Mar 6.

PMID:
22392074
14.

Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.

Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I.

Cancer Sci. 2011 Mar;102(3):605-13. doi: 10.1111/j.1349-7006.2010.01821.x. Epub 2011 Jan 12.

15.

Inhibition of the p53-MDM2 interaction by adenovirus delivery of ribosomal protein L23 stabilizes p53 and induces cell cycle arrest and apoptosis in gastric cancer.

Zhang Y, Shi Y, Li X, Du W, Luo G, Gou Y, Wang X, Guo X, Liu J, Ding J, Wu K, Fan D.

J Gene Med. 2010 Feb;12(2):147-56. doi: 10.1002/jgm.1424.

PMID:
20020415
16.

A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression.

Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T.

Eur J Cancer. 2012 Sep;48(14):2282-91. doi: 10.1016/j.ejca.2011.12.020. Epub 2012 Jan 13.

PMID:
22244827
17.

Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme.

Villalonga-Planells R, Coll-Mulet L, Martínez-Soler F, Castaño E, Acebes JJ, Giménez-Bonafé P, Gil J, Tortosa A.

PLoS One. 2011 Apr 5;6(4):e18588. doi: 10.1371/journal.pone.0018588.

18.

Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin.

Efeyan A, Ortega-Molina A, Velasco-Miguel S, Herranz D, Vassilev LT, Serrano M.

Cancer Res. 2007 Aug 1;67(15):7350-7.

19.

MDM-2 antagonists induce p53-dependent cell cycle arrest but not cell death in renal cancer cell lines.

Tsao CC, Corn PG.

Cancer Biol Ther. 2010 Dec 15;10(12):1315-25. Epub 2010 Dec 15.

PMID:
20953142
20.

Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.

Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S.

Leukemia. 2009 Nov;23(11):2090-101. doi: 10.1038/leu.2009.171. Epub 2009 Aug 27.

PMID:
19710698
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