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Items: 1 to 20 of 97


The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing.

Wong AH, Zhou D, Rini JM.

J Biol Chem. 2012 Oct 26;287(44):36804-13. doi: 10.1074/jbc.M112.398842. Epub 2012 Aug 29.


Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition.

Ito K, Nakajima Y, Onohara Y, Takeo M, Nakashima K, Matsubara F, Ito T, Yoshimoto T.

J Biol Chem. 2006 Nov 3;281(44):33664-76. Epub 2006 Aug 2.


Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site.

Addlagatta A, Gay L, Matthews BW.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13339-44. Epub 2006 Aug 28.


Crystal structure of the leucine aminopeptidase from Pseudomonas putida reveals the molecular basis for its enantioselectivity and broad substrate specificity.

Kale A, Pijning T, Sonke T, Dijkstra BW, Thunnissen AM.

J Mol Biol. 2010 May 21;398(5):703-14. doi: 10.1016/j.jmb.2010.03.042. Epub 2010 Mar 30.


Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Velmourougane G, Harbut MB, Dalal S, McGowan S, Oellig CA, Meinhardt N, Whisstock JC, Klemba M, Greenbaum DC.

J Med Chem. 2011 Mar 24;54(6):1655-66. doi: 10.1021/jm101227t. Epub 2011 Mar 2.


Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.

Maruyama M, Hattori A, Goto Y, Ueda M, Maeda M, Fujiwara H, Tsujimoto M.

J Biol Chem. 2007 Jul 13;282(28):20088-96. Epub 2007 May 24.


Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW.

BMC Struct Biol. 2012 Jun 21;12:14. doi: 10.1186/1472-6807-12-14.


Simulated interactions between angiotensin-converting enzyme and substrate gonadotropin-releasing hormone: novel insights into domain selectivity.

Papakyriakou A, Spyroulias GA, Sturrock ED, Manessi-Zoupa E, Cordopatis P.

Biochemistry. 2007 Jul 31;46(30):8753-65. Epub 2007 Jul 3.


Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.

Ascher DB, Cromer BA, Morton CJ, Volitakis I, Cherny RA, Albiston AL, Chai SY, Parker MW.

Biochemistry. 2011 Apr 5;50(13):2611-22. doi: 10.1021/bi101893w. Epub 2011 Mar 9.


Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.

Su J, Wang Q, Feng J, Zhang C, Zhu D, Wei T, Xu W, Gu L.

Bioorg Med Chem. 2011 May 1;19(9):2991-6. doi: 10.1016/j.bmc.2011.03.028. Epub 2011 Mar 21.


Structure of signal peptide peptidase A with C-termini bound in the active sites: insights into specificity, self-processing, and regulation.

Nam SE, Paetzel M.

Biochemistry. 2013 Dec 10;52(49):8811-22. doi: 10.1021/bi4011489. Epub 2013 Nov 25.


Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.

Knapp K, Zebisch M, Pippel J, El-Tayeb A, Müller CE, Sträter N.

Structure. 2012 Dec 5;20(12):2161-73. doi: 10.1016/j.str.2012.10.001. Epub 2012 Nov 8.


The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations.

Jones PM, Robinson MW, Dalton JP, George AM.

PLoS One. 2011;6(12):e28589. doi: 10.1371/journal.pone.0028589. Epub 2011 Dec 21.


Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.

McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2537-42. doi: 10.1073/pnas.0807398106. Epub 2009 Feb 5.


Structural features of angiotensin-I converting enzyme catalytic sites: conformational studies in solution, homology models and comparison with other zinc metallopeptidases.

Spyroulias GA, Galanis AS, Pairas G, Manessi-Zoupa E, Cordopatis P.

Curr Top Med Chem. 2004;4(4):403-29. Review.


Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica.

Stamper CC, Bienvenue DL, Bennett B, Ringe D, Petsko GA, Holz RC.

Biochemistry. 2004 Aug 3;43(30):9620-8.


Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.

Unno H, Yamashita T, Ujita S, Okumura N, Otani H, Okumura A, Nagai K, Kusunoki M.

J Biol Chem. 2008 Oct 3;283(40):27289-99. doi: 10.1074/jbc.M801657200. Epub 2008 Jun 12.


Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.

Kyrieleis OJ, Goettig P, Kiefersauer R, Huber R, Brandstetter H.

J Mol Biol. 2005 Jun 17;349(4):787-800. Epub 2005 Apr 26.

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