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Results: 1 to 20 of 94

1.

Evaluation of drug supersaturation by thermodynamic and kinetic approaches for the prediction of oral absorbability in amorphous pharmaceuticals.

Ozaki S, Kushida I, Yamashita T, Hasebe T, Shirai O, Kano K.

J Pharm Sci. 2012 Nov;101(11):4220-30. doi: 10.1002/jps.23306. Epub 2012 Aug 28.

PMID:
22930424
[PubMed - indexed for MEDLINE]
2.

Supersaturation-nucleation behavior of poorly soluble drugs and its impact on the oral absorption of drugs in thermodynamically high-energy forms.

Ozaki S, Minamisono T, Yamashita T, Kato T, Kushida I.

J Pharm Sci. 2012 Jan;101(1):214-22. doi: 10.1002/jps.22760. Epub 2011 Sep 14.

PMID:
21918988
[PubMed - indexed for MEDLINE]
3.

Inhibition of crystal nucleation and growth by water-soluble polymers and its impact on the supersaturation profiles of amorphous drugs.

Ozaki S, Kushida I, Yamashita T, Hasebe T, Shirai O, Kano K.

J Pharm Sci. 2013 Jul;102(7):2273-81. doi: 10.1002/jps.23588. Epub 2013 May 8.

PMID:
23658029
[PubMed - indexed for MEDLINE]
4.

Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs.

Sarode AL, Wang P, Obara S, Worthen DR.

Eur J Pharm Biopharm. 2014 Apr;86(3):351-60. doi: 10.1016/j.ejpb.2013.10.005. Epub 2013 Oct 24.

PMID:
24161655
[PubMed - indexed for MEDLINE]
5.

Evolution of supersaturation of amorphous pharmaceuticals: the effect of rate of supersaturation generation.

Sun DD, Lee PI.

Mol Pharm. 2013 Nov 4;10(11):4330-46. doi: 10.1021/mp400439q. Epub 2013 Oct 14.

PMID:
24066837
[PubMed - indexed for MEDLINE]
6.

Quantitative analysis of the effect of supersaturation on in vivo drug absorption.

Takano R, Takata N, Saito R, Furumoto K, Higo S, Hayashi Y, Machida M, Aso Y, Yamashita S.

Mol Pharm. 2010 Oct 4;7(5):1431-40. doi: 10.1021/mp100109a. Epub 2010 Aug 12.

PMID:
20704264
[PubMed - indexed for MEDLINE]
7.

Supersaturation produces high bioavailability of amorphous danazol particles formed by evaporative precipitation into aqueous solution and spray freezing into liquid technologies.

Vaughn JM, McConville JT, Crisp MT, Johnston KP, Williams RO 3rd.

Drug Dev Ind Pharm. 2006 Jun;32(5):559-67.

PMID:
16720411
[PubMed - indexed for MEDLINE]
8.

In vitro-in vivo correlation of the effect of supersaturation on the intestinal absorption of BCS Class 2 drugs.

Higashino H, Hasegawa T, Yamamoto M, Matsui R, Masaoka Y, Kataoka M, Sakuma S, Yamashita S.

Mol Pharm. 2014 Mar 3;11(3):746-54. doi: 10.1021/mp400465p. Epub 2014 Feb 6.

PMID:
24460473
[PubMed - in process]
9.

Amorphous compositions using concentration enhancing polymers for improved bioavailability of itraconazole.

DiNunzio JC, Miller DA, Yang W, McGinity JW, Williams RO 3rd.

Mol Pharm. 2008 Nov-Dec;5(6):968-80. doi: 10.1021/mp800042d.

PMID:
19434851
[PubMed - indexed for MEDLINE]
10.

Prediction of the plasma concentration profiles of orally administered drugs in rats on the basis of gastrointestinal transit kinetics and absorbability.

Sawamoto T, Haruta S, Kurosaki Y, Higaki K, Kimura T.

J Pharm Pharmacol. 1997 Apr;49(4):450-7.

PMID:
9232547
[PubMed - indexed for MEDLINE]
11.

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.

Williams HD, Trevaskis NL, Yeap YY, Anby MU, Pouton CW, Porter CJ.

Pharm Res. 2013 Dec;30(12):2976-92. doi: 10.1007/s11095-013-1126-0. Epub 2013 Jul 4. Review.

PMID:
23824582
[PubMed - indexed for MEDLINE]
12.

Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels.

Sun DD, Ju TC, Lee PI.

Eur J Pharm Biopharm. 2012 May;81(1):149-58. doi: 10.1016/j.ejpb.2011.12.016. Epub 2012 Jan 2.

PMID:
22233548
[PubMed - indexed for MEDLINE]
13.

Amorphization strategy affects the stability and supersaturation profile of amorphous drug nanoparticles.

Cheow WS, Kiew TY, Yang Y, Hadinoto K.

Mol Pharm. 2014 May 5;11(5):1611-20. doi: 10.1021/mp400788p. Epub 2014 Apr 4.

PMID:
24669821
[PubMed - indexed for MEDLINE]
14.

Effect of surfactants, gastric emptying, and dosage form on supersaturation of dipyridamole in an in vitro model simulating the stomach and duodenum.

Mitra A, Fadda HM.

Mol Pharm. 2014 Aug 4;11(8):2835-44. doi: 10.1021/mp500196f. Epub 2014 Jul 15.

PMID:
25025699
[PubMed - in process]
15.

Design of potent amorphous drug nanoparticles for rapid generation of highly supersaturated media.

Matteucci ME, Brettmann BK, Rogers TL, Elder EJ, Williams RO 3rd, Johnston KP.

Mol Pharm. 2007 Sep-Oct;4(5):782-93. Epub 2007 Aug 24.

PMID:
17715989
[PubMed - indexed for MEDLINE]
16.

Physicochemical profiling (solubility, permeability and charge state).

Avdeef A.

Curr Top Med Chem. 2001 Sep;1(4):277-351. Review.

PMID:
11899112
[PubMed - indexed for MEDLINE]
17.

Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution study.

Fujioka Y, Kadono K, Fujie Y, Metsugi Y, Ogawara K, Higaki K, Kimura T.

J Control Release. 2007 Jun 4;119(2):222-8. Epub 2007 Mar 13.

PMID:
17442444
[PubMed - indexed for MEDLINE]
18.

Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis.

Murdande SB, Pikal MJ, Shanker RM, Bogner RH.

J Pharm Sci. 2010 Mar;99(3):1254-64. doi: 10.1002/jps.21903.

PMID:
19697391
[PubMed - indexed for MEDLINE]
19.

In vitro system to evaluate oral absorption of poorly water-soluble drugs: simultaneous analysis on dissolution and permeation of drugs.

Kataoka M, Masaoka Y, Yamazaki Y, Sakane T, Sezaki H, Yamashita S.

Pharm Res. 2003 Oct;20(10):1674-80.

PMID:
14620525
[PubMed - indexed for MEDLINE]
20.

Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport.

Mellaerts R, Mols R, Kayaert P, Annaert P, Van Humbeeck J, Van den Mooter G, Martens JA, Augustijns P.

Int J Pharm. 2008 Jun 5;357(1-2):169-79. doi: 10.1016/j.ijpharm.2008.01.049. Epub 2008 Feb 3.

PMID:
18325700
[PubMed - indexed for MEDLINE]
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