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Results: 1 to 20 of 125

1.

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

Minond D, Cudic M, Bionda N, Giulianotti M, Maida L, Houghten RA, Fields GB.

J Biol Chem. 2012 Oct 19;287(43):36473-87. doi: 10.1074/jbc.M112.389114. Epub 2012 Aug 27.

PMID:
22927435
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.

Stawikowska R, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D.

J Biol Chem. 2013 Aug 2;288(31):22871-9. doi: 10.1074/jbc.M113.462267. Epub 2013 Jun 18.

PMID:
23779109
[PubMed - indexed for MEDLINE]
3.

ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha.

Le Gall SM, Bobé P, Reiss K, Horiuchi K, Niu XD, Lundell D, Gibb DR, Conrad D, Saftig P, Blobel CP.

Mol Biol Cell. 2009 Mar;20(6):1785-94. doi: 10.1091/mbc.E08-11-1135. Epub 2009 Jan 21.

PMID:
19158376
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

Moss ML, Rasmussen FH.

Anal Biochem. 2007 Jul 15;366(2):144-8. Epub 2007 May 3.

PMID:
17548045
[PubMed - indexed for MEDLINE]
5.

Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme.

Escrevente C, Morais VA, Keller S, Soares CM, Altevogt P, Costa J.

Biochim Biophys Acta. 2008 Jun;1780(6):905-13. doi: 10.1016/j.bbagen.2008.03.004. Epub 2008 Mar 13.

PMID:
18381078
[PubMed - indexed for MEDLINE]
Free Article
6.

The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential?

Saftig P, Reiss K.

Eur J Cell Biol. 2011 Jun-Jul;90(6-7):527-35. doi: 10.1016/j.ejcb.2010.11.005. Epub 2010 Dec 30. Review.

PMID:
21194787
[PubMed - indexed for MEDLINE]
7.

The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition.

Rapti M, Atkinson SJ, Lee MH, Trim A, Moss M, Murphy G.

Biochem J. 2008 Apr 15;411(2):433-9. doi: 10.1042/BJ20071430.

PMID:
18215140
[PubMed - indexed for MEDLINE]
Free Article
8.

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.

Chavaroche A, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D.

Anal Biochem. 2014 Mar 15;449:68-75. doi: 10.1016/j.ab.2013.12.018. Epub 2013 Dec 19.

PMID:
24361716
[PubMed - in process]
9.

Identification of ADAM10 as a major TNF sheddase in ADAM17-deficient fibroblasts.

Mezyk-Kopeć R, Bzowska M, Stalińska K, Chełmicki T, Podkalicki M, Jucha J, Kowalczyk K, Mak P, Bereta J.

Cytokine. 2009 Jun;46(3):309-15. doi: 10.1016/j.cyto.2009.03.002. Epub 2009 Apr 5.

PMID:
19346138
[PubMed - indexed for MEDLINE]
10.

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10.

Caescu CI, Jeschke GR, Turk BE.

Biochem J. 2009 Oct 23;424(1):79-88. doi: 10.1042/BJ20090549.

PMID:
19715556
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.

Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW.

J Biol Chem. 2011 Nov 25;286(47):40443-51. doi: 10.1074/jbc.M111.280495. Epub 2011 Sep 28.

PMID:
21956108
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.

Ebsen H, Schröder A, Kabelitz D, Janssen O.

PLoS One. 2013 Oct 9;8(10):e76853. doi: 10.1371/journal.pone.0076853. eCollection 2013.

PMID:
24130797
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.

Bakken AM, Protack CD, Roztocil E, Nicholl SM, Davies MG.

J Vasc Surg. 2009 May;49(5):1296-303. doi: 10.1016/j.jvs.2008.12.026.

PMID:
19394555
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.

Pruessmeyer J, Ludwig A.

Semin Cell Dev Biol. 2009 Apr;20(2):164-74. doi: 10.1016/j.semcdb.2008.09.005. Epub 2008 Sep 18. Review.

PMID:
18951988
[PubMed - indexed for MEDLINE]
15.

A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3).

Möller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J.

J Biol Chem. 2013 Nov 29;288(48):34529-44. doi: 10.1074/jbc.M113.488478. Epub 2013 Oct 11.

PMID:
24121505
[PubMed - indexed for MEDLINE]
16.

Acetylenic inhibitors of ADAM10 and ADAM17: in silico analysis of potency and selectivity.

Healy EF, Romano P, Mejia M, Lindfors G 3rd.

J Mol Graph Model. 2010 Nov;29(3):436-42. doi: 10.1016/j.jmgm.2010.08.006. Epub 2010 Sep 21.

PMID:
20863729
[PubMed - indexed for MEDLINE]
17.

Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.

Esselens CW, Malapeira J, Colomé N, Moss M, Canals F, Arribas J.

Biol Chem. 2008 Aug;389(8):1075-84.

PMID:
18979631
[PubMed - indexed for MEDLINE]
18.

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.

Chitadze G, Lettau M, Bhat J, Wesch D, Steinle A, Fürst D, Mytilineos J, Kalthoff H, Janssen O, Oberg HH, Kabelitz D.

Int J Cancer. 2013 Oct 1;133(7):1557-66. doi: 10.1002/ijc.28174. Epub 2013 Apr 18.

PMID:
23526433
[PubMed - indexed for MEDLINE]
19.

Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.

Deuss M, Reiss K, Hartmann D.

Curr Alzheimer Res. 2008 Apr;5(2):187-201. Review.

PMID:
18393804
[PubMed - indexed for MEDLINE]
20.

Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD.

Comb Chem High Throughput Screen. 2005 Mar;8(2):161-71. Review.

PMID:
15777180
[PubMed - indexed for MEDLINE]

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