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Results: 1 to 20 of 99

1.

High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.

Cerignoli F, Charlot D, Whittaker R, Ingermanson R, Gehalot P, Savchenko A, Gallacher DJ, Towart R, Price JH, McDonough PM, Mercola M.

J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):246-56. doi: 10.1016/j.vascn.2012.08.167. Epub 2012 Aug 25.

PMID:
22926323
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.

Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):500-7. doi: 10.1016/j.taap.2013.09.017. Epub 2013 Oct 1.

PMID:
24095675
[PubMed - indexed for MEDLINE]
3.

Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds.

Himmel HM.

J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):97-111. doi: 10.1016/j.vascn.2013.05.005. Epub 2013 May 20.

PMID:
23702537
[PubMed - indexed for MEDLINE]
4.

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment.

Abassi YA, Xi B, Li N, Ouyang W, Seiler A, Watzele M, Kettenhofen R, Bohlen H, Ehlich A, Kolossov E, Wang X, Xu X.

Br J Pharmacol. 2012 Mar;165(5):1424-41. doi: 10.1111/j.1476-5381.2011.01623.x.

PMID:
21838757
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Development of high content imaging methods for cell death detection in human pluripotent stem cell-derived cardiomyocytes.

Mioulane M, Foldes G, Ali NN, Schneider MD, Harding SE.

J Cardiovasc Transl Res. 2012 Oct;5(5):593-604. Epub 2012 Aug 16.

PMID:
22896035
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards.

Mordwinkin NM, Burridge PW, Wu JC.

J Cardiovasc Transl Res. 2013 Feb;6(1):22-30. doi: 10.1007/s12265-012-9423-2. Epub 2012 Nov 15. Review.

PMID:
23229562
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models.

Kraushaar U, Meyer T, Hess D, Gepstein L, Mummery CL, Braam SR, Guenther E.

Expert Opin Drug Saf. 2012 Mar;11(2):285-98. doi: 10.1517/14740338.2012.639358. Epub 2011 Nov 22. Review.

PMID:
22103746
[PubMed - indexed for MEDLINE]
8.

Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes.

Kang J, Chen XL, Ji J, Lei Q, Rampe D.

J Pharmacol Exp Ther. 2012 May;341(2):510-7. doi: 10.1124/jpet.112.192609. Epub 2012 Feb 21.

PMID:
22353878
[PubMed - indexed for MEDLINE]
Free Article
9.

Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.

Guo L, Abrams RM, Babiarz JE, Cohen JD, Kameoka S, Sanders MJ, Chiao E, Kolaja KL.

Toxicol Sci. 2011 Sep;123(1):281-9. doi: 10.1093/toxsci/kfr158. Epub 2011 Jun 20.

PMID:
21693436
[PubMed - indexed for MEDLINE]
Free Article
10.

Induced pluripotent stem cells in cardiovascular drug discovery.

Mercola M, Colas A, Willems E.

Circ Res. 2013 Feb 1;112(3):534-48. doi: 10.1161/CIRCRESAHA.111.250266. Review.

PMID:
23371902
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Caveats and limitations of plate reader-based high-throughput kinetic measurements of intracellular calcium levels.

Heusinkveld HJ, Westerink RH.

Toxicol Appl Pharmacol. 2011 Aug 15;255(1):1-8. doi: 10.1016/j.taap.2011.05.020. Epub 2011 Jun 12.

PMID:
21684299
[PubMed - indexed for MEDLINE]
12.

In vitro uses of human pluripotent stem cell-derived cardiomyocytes.

Matsa E, Denning C.

J Cardiovasc Transl Res. 2012 Oct;5(5):581-92. Epub 2012 May 26. Review.

PMID:
22639342
[PubMed - indexed for MEDLINE]
13.

Evaluation of novel high-throughput embryonic stem cell tests with new molecular markers for screening embryotoxic chemicals in vitro.

Suzuki N, Ando S, Yamashita N, Horie N, Saito K.

Toxicol Sci. 2011 Dec;124(2):460-71. doi: 10.1093/toxsci/kfr250. Epub 2011 Sep 29.

PMID:
21964422
[PubMed - indexed for MEDLINE]
Free Article
14.

Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System.

Xi B, Wang T, Li N, Ouyang W, Zhang W, Wu J, Xu X, Wang X, Abassi YA.

J Lab Autom. 2011 Dec;16(6):415-21. doi: 10.1016/j.jala.2011.09.002.

PMID:
22093298
[PubMed - indexed for MEDLINE]
Free Article
15.

Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants.

Qian JY, Guo L.

Toxicol In Vitro. 2010 Apr;24(3):960-72. doi: 10.1016/j.tiv.2009.12.027. Epub 2010 Jan 11.

PMID:
20064605
[PubMed - indexed for MEDLINE]
16.

Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes.

Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, Keller G, Kong CW, Li RA.

Circ Arrhythm Electrophysiol. 2013 Feb;6(1):191-201. doi: 10.1161/CIRCEP.111.973420. Epub 2013 Feb 7.

PMID:
23392582
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm.

Willems E, Spiering S, Davidovics H, Lanier M, Xia Z, Dawson M, Cashman J, Mercola M.

Circ Res. 2011 Aug 5;109(4):360-4. doi: 10.1161/CIRCRESAHA.111.249540. Epub 2011 Jul 7.

PMID:
21737789
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes.

Lee YK, Ng KM, Lai WH, Chan YC, Lau YM, Lian Q, Tse HF, Siu CW.

Stem Cell Rev. 2011 Nov;7(4):976-86. doi: 10.1007/s12015-011-9273-3.

PMID:
21614516
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Human embryonic and induced pluripotent stem cells in cardiovascular drug discovery: patents and patented uses.

Ivashchenko CY.

Recent Pat Cardiovasc Drug Discov. 2011 Sep;6(3):199-206. Review.

PMID:
21861824
[PubMed - indexed for MEDLINE]
20.

Human stem cells and drug screening: opportunities and challenges.

Ebert AD, Svendsen CN.

Nat Rev Drug Discov. 2010 May;9(5):367-72. doi: 10.1038/nrd3000. Epub 2010 Mar 26.

PMID:
20339370
[PubMed - indexed for MEDLINE]

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