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Items: 1 to 20 of 97


RSK2 as a key regulator in human skin cancer.

Cho YY, Lee MH, Lee CJ, Yao K, Lee HS, Bode AM, Dong Z.

Carcinogenesis. 2012 Dec;33(12):2529-37. doi: 10.1093/carcin/bgs271. Epub 2012 Aug 23.


Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.

Cho YY, Yao K, Kim HG, Kang BS, Zheng D, Bode AM, Dong Z.

Cancer Res. 2007 Sep 1;67(17):8104-12.


A regulatory mechanism for RSK2 NH(2)-terminal kinase activity.

Cho YY, Yao K, Pugliese A, Malakhova ML, Bode AM, Dong Z.

Cancer Res. 2009 May 15;69(10):4398-406. doi: 10.1158/0008-5472.CAN-08-4959. Epub 2009 May 12.


A Rising Cancer Prevention Target of RSK2 in Human Skin Cancer.

Arul N, Cho YY.

Front Oncol. 2013 Aug 5;3:201. doi: 10.3389/fonc.2013.00201. eCollection 2013.


RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity.

Lee CJ, Lee MH, Lee JY, Song JH, Lee HS, Cho YY.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):112-8. doi: 10.1016/j.bbrc.2013.09.042. Epub 2013 Sep 17.


Targeting of magnolin on ERKs inhibits Ras/ERKs/RSK2-signaling-mediated neoplastic cell transformation.

Lee CJ, Lee HS, Ryu HW, Lee MH, Lee JY, Li Y, Dong Z, Lee HK, Oh SR, Cho YY.

Carcinogenesis. 2014 Feb;35(2):432-41. doi: 10.1093/carcin/bgt306. Epub 2013 Sep 12.


Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation.

Liu K, Cho YY, Yao K, Nadas J, Kim DJ, Cho EJ, Lee MH, Pugliese A, Zhang J, Bode AM, Dong Z, Dong Z.

J Biol Chem. 2011 Jan 21;286(3):2057-66. doi: 10.1074/jbc.M110.147306. Epub 2010 Nov 22.


Molecular Targeting of ERKs/RSK2 Signaling Axis in Cancer Prevention.

Yoo SM, Cho SJ, Cho YY.

J Cancer Prev. 2015 Sep;20(3):165-71. doi: 10.15430/JCP.2015.20.3.165. Review.


Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway.

Peng C, Zhu F, Wen W, Yao K, Li S, Zykova T, Liu K, Li X, Ma WY, Bode AM, Dong Z.

J Biol Chem. 2012 Jul 27;287(31):25881-92. doi: 10.1074/jbc.M112.359521. Epub 2012 Jun 8.


5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer.

Lee KM, Lee KW, Byun S, Jung SK, Seo SK, Heo YS, Bode AM, Lee HJ, Dong Z.

Cancer Prev Res (Phila). 2010 Apr;3(4):454-65. doi: 10.1158/1940-6207.CAPR-09-0137. Epub 2010 Mar 16.


Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).

Zykova TA, Zhu F, Zhang Y, Bode AM, Dong Z.

Carcinogenesis. 2007 Jul;28(7):1543-51. Epub 2007 Apr 2.


Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots.

Berghe WV, De Naeyer A, Dijsselbloem N, David JP, De Keukeleire D, Haegeman G.

Endocr Metab Immune Disord Drug Targets. 2011 Sep 1;11(3):247-61.


p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.

Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J.

J Clin Invest. 2010 Apr;120(4):1165-77. doi: 10.1172/JCI40582. Epub 2010 Mar 15.


Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.

Kang S, Dong S, Guo A, Ruan H, Lonial S, Khoury HJ, Gu TL, Chen J.

J Biol Chem. 2008 Feb 22;283(8):4652-7. Epub 2007 Dec 21.


The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.

Ma C, Wang J, Gao Y, Gao TW, Chen G, Bower KA, Odetallah M, Ding M, Ke Z, Luo J.

Cancer Res. 2007 Aug 15;67(16):7756-64.


P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.

Li T, Zhang J, Zhu F, Wen W, Zykova T, Li X, Liu K, Peng C, Ma W, Shi G, Dong Z, Bode AM, Dong Z.

Carcinogenesis. 2011 May;32(5):659-66. doi: 10.1093/carcin/bgq271. Epub 2010 Dec 22.


Phosphorylation of histone H2B serine 32 is linked to cell transformation.

Lau AT, Lee SY, Xu YM, Zheng D, Cho YY, Zhu F, Kim HG, Li SQ, Zhang Z, Bode AM, Dong Z.

J Biol Chem. 2011 Jul 29;286(30):26628-37. doi: 10.1074/jbc.M110.215590. Epub 2011 Jun 6.


FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J.

Cancer Cell. 2007 Sep;12(3):201-14.

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