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Results: 1 to 20 of 101

1.

Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen.

Kim J, Coss CC, Barrett CM, Mohler ML, Bohl CE, Li CM, He Y, Veverka KA, Dalton JT.

Int J Cancer. 2013 Mar 15;132(6):1475-85. doi: 10.1002/ijc.27794. Epub 2012 Sep 14.

PMID:
22915089
[PubMed - indexed for MEDLINE]
2.

Sulfation of 4-hydroxy toremifene: individual variability, isoform specificity, and contribution to toremifene pharmacogenomics.

Edavana VK, Dhakal IB, Yu X, Williams S, Kadlubar S.

Drug Metab Dispos. 2012 Jun;40(6):1210-5. doi: 10.1124/dmd.111.044040. Epub 2012 Mar 20.

PMID:
22434874
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Influence of different combinations of tamoxifen and toremifene on estrogen receptor-positive breast cancer cell lines.

Coradini D, Biffi A, Cappelletti V, Di Fronzo G.

Cancer Detect Prev. 1995;19(4):348-54.

PMID:
7553677
[PubMed - indexed for MEDLINE]
4.

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.

Stearns V, Johnson MD, Rae JM, Morocho A, Novielli A, Bhargava P, Hayes DF, Desta Z, Flockhart DA.

J Natl Cancer Inst. 2003 Dec 3;95(23):1758-64.

PMID:
14652237
[PubMed - indexed for MEDLINE]
Free Article
5.

In vitro and in vivo binding of toremifene and its metabolites in rat uterus.

Simberg NH, Murai JT, Siiteri PK.

J Steroid Biochem. 1990 Jun 22;36(3):197-202.

PMID:
2142232
[PubMed - indexed for MEDLINE]
6.

Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.

Zhou SF.

Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000.

PMID:
19902987
[PubMed - indexed for MEDLINE]
7.

Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.

Kim SY, Suzuki N, Santosh Laxmi YR, Rieger R, Shibutani S.

Chem Res Toxicol. 2003 Sep;16(9):1138-44.

PMID:
12971802
[PubMed - indexed for MEDLINE]
8.

[Assessment of post-administration body distribution of toremifene and tamoxifen, and their administration regimens].

Masuoka H, Mori M, Nomura N, Sakurai M, Yoshida K, Usuda N, Shirai H, Shimokawara I, Asaishi K.

Gan To Kagaku Ryoho. 2002 Jun;29(6):881-7. Japanese.

PMID:
12090039
[PubMed - indexed for MEDLINE]
9.

CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.

Dehal SS, Kupfer D.

Cancer Res. 1997 Aug 15;57(16):3402-6.

PMID:
9270005
[PubMed - indexed for MEDLINE]
Free Article
10.

The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review.

Fleeman N, Martin Saborido C, Payne K, Boland A, Dickson R, Dundar Y, Fernández Santander A, Howell S, Newman W, Oyee J, Walley T.

Health Technol Assess. 2011 Sep;15(33):1-102. doi: 10.3310/hta15330. Review.

PMID:
21906462
[PubMed - indexed for MEDLINE]
Free Article
11.

DNA damage and altered gene expression of enzymes for metabolism and DNA repair by tamoxifen and toremifene in the female rat liver.

Hashiba M, Kasahara T, Kim SY, Shibutani S, Degawa M.

Cancer Sci. 2006 Jun;97(6):468-77.

PMID:
16734724
[PubMed - indexed for MEDLINE]
12.

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.

Borges S, Desta Z, Li L, Skaar TC, Ward BA, Nguyen A, Jin Y, Storniolo AM, Nikoloff DM, Wu L, Hillman G, Hayes DF, Stearns V, Flockhart DA.

Clin Pharmacol Ther. 2006 Jul;80(1):61-74.

PMID:
16815318
[PubMed - indexed for MEDLINE]
14.

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.

Lim YC, Li L, Desta Z, Zhao Q, Rae JM, Flockhart DA, Skaar TC.

J Pharmacol Exp Ther. 2006 Aug;318(2):503-12. Epub 2006 May 11.

PMID:
16690721
[PubMed - indexed for MEDLINE]
Free Article
15.

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.

Desta Z, Ward BA, Soukhova NV, Flockhart DA.

J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. Epub 2004 May 24.

PMID:
15159443
[PubMed - indexed for MEDLINE]
Free Article
16.

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.

Jin Y, Desta Z, Stearns V, Ward B, Ho H, Lee KH, Skaar T, Storniolo AM, Li L, Araba A, Blanchard R, Nguyen A, Ullmer L, Hayden J, Lemler S, Weinshilboum RM, Rae JM, Hayes DF, Flockhart DA.

J Natl Cancer Inst. 2005 Jan 5;97(1):30-9.

PMID:
15632378
[PubMed - indexed for MEDLINE]
Free Article
17.

Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.

Lim YC, Desta Z, Flockhart DA, Skaar TC.

Cancer Chemother Pharmacol. 2005 May;55(5):471-8. Epub 2005 Feb 1.

PMID:
15685451
[PubMed - indexed for MEDLINE]
18.

Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy.

Antunes MV, Linden R, Santos TV, Wallemacq P, Haufroid V, Classen JF, Andreolla H, Costa N, Fontanive TO, Rosa DD.

Ther Drug Monit. 2012 Aug;34(4):422-31. doi: 10.1097/FTD.0b013e318260b46e.

PMID:
22777153
[PubMed - indexed for MEDLINE]
19.

Tamoxifen metabolite isomer separation and quantification by liquid chromatography-tandem mass spectrometry.

Jaremko M, Kasai Y, Barginear MF, Raptis G, Desnick RJ, Yu C.

Anal Chem. 2010 Dec 15;82(24):10186-93. doi: 10.1021/ac102337d. Epub 2010 Nov 18.

PMID:
21086978
[PubMed - indexed for MEDLINE]
20.

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen.

Johnson MD, Zuo H, Lee KH, Trebley JP, Rae JM, Weatherman RV, Desta Z, Flockhart DA, Skaar TC.

Breast Cancer Res Treat. 2004 May;85(2):151-9.

PMID:
15111773
[PubMed - indexed for MEDLINE]

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