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Items: 1 to 20 of 115


Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes.

O'Connor T, Frei N, Sponarova J, Schwarz P, Heikenwalder M, Aguzzi A.

PLoS Pathog. 2012;8(8):e1002867. doi: 10.1371/journal.ppat.1002867. Epub 2012 Aug 9.


Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells.

Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, Odermatt B, Pfeffer K, Aguzzi A.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):919-24. Epub 2002 Jan 15.


Prions and lymphoid organs: solved and remaining mysteries.

O'Connor T, Aguzzi A.

Prion. 2013 Mar-Apr;7(2):157-63. doi: 10.4161/pri.23536. Epub 2013 Jan 28.


Impaired prion replication in spleens of mice lacking functional follicular dendritic cells.

Montrasio F, Frigg R, Glatzel M, Klein MA, Mackay F, Aguzzi A, Weissmann C.

Science. 2000 May 19;288(5469):1257-9.


Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas.

Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A.

Immunity. 2008 Dec 19;29(6):998-1008. doi: 10.1016/j.immuni.2008.10.014.


A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep.

Maestrale C, Di Guardo G, Cancedda MG, Marruchella G, Masia M, Sechi S, Macciocu S, Santucciu C, Petruzzi M, Ligios C.

PLoS One. 2013 May 3;8(5):e62830. doi: 10.1371/journal.pone.0062830. Print 2013.


Current concepts and controversies in prion immunopathology.

Heikenwalder M, Prinz M, Heppner FL, Aguzzi A.

J Mol Neurosci. 2004;23(1-2):3-12. Review.


Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells.

Brown KL, Stewart K, Ritchie DL, Mabbott NA, Williams A, Fraser H, Morrison WI, Bruce ME.

Nat Med. 1999 Nov;5(11):1308-12.


Role of the GALT in scrapie agent neuroinvasion from the intestine.

Glaysher BR, Mabbott NA.

J Immunol. 2007 Mar 15;178(6):3757-66.


Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion.

Oldstone MB, Race R, Thomas D, Lewicki H, Homann D, Smelt S, Holz A, Koni P, Lo D, Chesebro B, Flavell R.

J Virol. 2002 May;76(9):4357-63.


Scrapie affects the maturation cycle and immune complex trapping by follicular dendritic cells in mice.

McGovern G, Mabbott N, Jeffrey M.

PLoS One. 2009 Dec 8;4(12):e8186. doi: 10.1371/journal.pone.0008186.


CD21-positive follicular dendritic cells: A possible source of PrPSc in lymph node macrophages of scrapie-infected sheep.

Herrmann LM, Cheevers WP, Davis WC, Knowles DP, O'Rourke KI.

Am J Pathol. 2003 Apr;162(4):1075-81.


Role of the draining lymph node in scrapie agent transmission from the skin.

Glaysher BR, Mabbott NA.

Immunol Lett. 2007 Mar 15;109(1):64-71. Epub 2007 Jan 31.


Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie.

Mabbott NA, Williams A, Farquhar CF, Pasparakis M, Kollias G, Bruce ME.

J Virol. 2000 Apr;74(7):3338-44.


Pathogenesis of scrapie in ARQ/ARQ sheep after subcutaneous infection: effect of lymphadenectomy and immune cell subset changes in relation to prion protein accumulation.

Chianini F, Sisó S, Ricci E, Eaton SL, Finlayson J, Pang Y, Hamilton S, Steele P, Reid HW, Cantile C, Sales J, Jeffrey M, Dagleish MP, González L.

Vet Immunol Immunopathol. 2013 Apr 15;152(3-4):348-58. doi: 10.1016/j.vetimm.2013.01.005. Epub 2013 Jan 21.

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