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Items: 1 to 20 of 96

1.

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis.

Weingärtner S, Zerr P, Tomcik M, Palumbo-Zerr K, Distler A, Dees C, Beyer C, Shankar SL, Cedzik D, Schafer PH, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 Nov;71(11):1895-9. doi: 10.1136/annrheumdis-2012-201784. Epub 2012 Aug 17.

PMID:
22904257
2.

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis.

Akhmetshina A, Venalis P, Dees C, Busch N, Zwerina J, Schett G, Distler O, Distler JH.

Arthritis Rheum. 2009 Jan;60(1):219-24. doi: 10.1002/art.24186.

3.

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.

Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, Cordazzo C, Zerr P, Akhmetshina A, Ruat M, Distler O, Beyer C, Schett G, Distler JH.

Ann Rheum Dis. 2012 May;71(5):785-9. doi: 10.1136/annrheumdis-2011-200883. Epub 2012 Mar 8.

PMID:
22402139
4.

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.

Reich N, Tomcik M, Zerr P, Lang V, Dees C, Avouac J, Palumbo K, Horn A, Akhmetshina A, Beyer C, Xie W, Bennett BL, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 May;71(5):737-45. doi: 10.1136/annrheumdis-2011-200412. Epub 2012 Jan 18.

PMID:
22258492
5.

Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis.

Tomcik M, Zerr P, Pitkowski J, Palumbo-Zerr K, Avouac J, Distler O, Becvar R, Senolt L, Schett G, Distler JH.

Ann Rheum Dis. 2014 Jun;73(6):1215-22. doi: 10.1136/annrheumdis-2012-203095. Epub 2013 May 9.

PMID:
23661493
6.

Activation of pregnane X receptor inhibits experimental dermal fibrosis.

Beyer C, Skapenko A, Distler A, Dees C, Reichert H, Munoz L, Leipe J, Schulze-Koops H, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2013 Apr;72(4):621-5. doi: 10.1136/annrheumdis-2012-202476. Epub 2013 Jan 4.

PMID:
23291432
7.

Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis.

Yoshizaki A, Yanaba K, Yoshizaki A, Iwata Y, Komura K, Ogawa F, Takenaka M, Shimizu K, Asano Y, Hasegawa M, Fujimoto M, Sato S.

Arthritis Rheum. 2010 Aug;62(8):2476-87. doi: 10.1002/art.27498.

8.

Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis.

Beyer C, Reich N, Schindler SC, Akhmetshina A, Dees C, Tomcik M, Hirth-Dietrich C, von Degenfeld G, Sandner P, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 Jun;71(6):1019-26. doi: 10.1136/annrheumdis-2011-200862. Epub 2012 Jan 30.

PMID:
22294631
9.

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis.

Beyer C, Reichert H, Akan H, Mallano T, Schramm A, Dees C, Palumbo-Zerr K, Lin NY, Distler A, Gelse K, Varga J, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2013 Jul;72(7):1255-8. doi: 10.1136/annrheumdis-2012-202544. Epub 2013 Apr 17.

PMID:
23595143
10.

Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis.

Distler JH, Jüngel A, Huber LC, Schulze-Horsel U, Zwerina J, Gay RE, Michel BA, Hauser T, Schett G, Gay S, Distler O.

Arthritis Rheum. 2007 Jan;56(1):311-22.

11.

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

Avouac J, Palumbo K, Tomcik M, Zerr P, Dees C, Horn A, Maurer B, Akhmetshina A, Beyer C, Sadowski A, Schneider H, Shiozawa S, Distler O, Schett G, Allanore Y, Distler JH.

Arthritis Rheum. 2012 May;64(5):1642-52. doi: 10.1002/art.33501.

12.

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling.

Distler A, Deloch L, Huang J, Dees C, Lin NY, Palumbo-Zerr K, Beyer C, Weidemann A, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2013 Sep 1;72(9):1575-80. doi: 10.1136/annrheumdis-2012-202275. Epub 2012 Nov 12.

PMID:
23148305
13.

A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis.

Hasegawa M, Matsushita Y, Horikawa M, Higashi K, Tomigahara Y, Kaneko H, Shirasaki F, Fujimoto M, Takehara K, Sato S.

Arthritis Rheum. 2009 Nov;60(11):3465-75. doi: 10.1002/art.24934.

14.

Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis.

Desallais L, Avouac J, Fréchet M, Elhai M, Ratsimandresy R, Montes M, Mouhsine H, Do H, Zagury JF, Allanore Y.

Arthritis Res Ther. 2014 Jul 24;16(4):R157. doi: 10.1186/ar4672.

15.

Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis.

Avouac J, Fürnrohr BG, Tomcik M, Palumbo K, Zerr P, Horn A, Dees C, Akhmetshina A, Beyer C, Distler O, Schett G, Allanore Y, Distler JH.

Arthritis Rheum. 2011 Mar;63(3):800-9. doi: 10.1002/art.30171.

16.

The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis.

Yoshizaki A, Yanaba K, Ogawa A, Iwata Y, Ogawa F, Takenaka M, Shimizu K, Asano Y, Kadono T, Sato S.

Arthritis Rheum. 2011 Oct;63(10):3086-97. doi: 10.1002/art.30470.

17.

Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis.

Huber LC, Distler JH, Moritz F, Hemmatazad H, Hauser T, Michel BA, Gay RE, Matucci-Cerinic M, Gay S, Distler O, Jüngel A.

Arthritis Rheum. 2007 Aug;56(8):2755-64.

18.

Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis.

Ruzehaji N, Avouac J, Elhai M, Frechet M, Frantz C, Ruiz B, Distler JH, Allanore Y.

Arthritis Res Ther. 2015 May 30;17:145. doi: 10.1186/s13075-015-0659-5.

19.

The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis.

Akhmetshina A, Dees C, Busch N, Beer J, Sarter K, Zwerina J, Zimmer A, Distler O, Schett G, Distler JH.

Arthritis Rheum. 2009 Apr;60(4):1129-36. doi: 10.1002/art.24395.

20.

Inhibition of sumoylation prevents experimental fibrosis.

Khodzhigorova A, Distler A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 Nov;71(11):1904-8. doi: 10.1136/annrheumdis-2012-201746. Epub 2012 Aug 17. Erratum in: Ann Rheum Dis. 2013 Jun;72(6):1110.

PMID:
22904261
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