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Results: 1 to 20 of 108

1.

Lead optimization through VLAK protocol: new annelated pyrrolo-pyrimidine derivatives as antitumor agents.

Lauria A, Patella C, Abbate I, Martorana A, Almerico AM.

Eur J Med Chem. 2012 Sep;55:375-83. doi: 10.1016/j.ejmech.2012.07.046. Epub 2012 Aug 4.

PMID:
22892346
[PubMed - indexed for MEDLINE]
2.

New annelated thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines, with potent anticancer activity, designed through VLAK protocol.

Lauria A, Abbate I, Patella C, Martorana A, Dattolo G, Almerico AM.

Eur J Med Chem. 2013 Apr;62:416-24. doi: 10.1016/j.ejmech.2013.01.019. Epub 2013 Jan 23.

PMID:
23395722
[PubMed - indexed for MEDLINE]
3.

Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line.

Jung MH, Kim H, Choi WK, El-Gamal MI, Park JH, Yoo KH, Sim TB, Lee SH, Baek D, Hah JM, Cho JH, Oh CH.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6538-43. doi: 10.1016/j.bmcl.2009.10.051. Epub 2009 Oct 15.

PMID:
19857963
[PubMed - indexed for MEDLINE]
4.

Synthesis and antiproliferative activity of 2,4-disubstituted 6-aryl-7H-pyrrolo[3,2-d]pyrimidin-7-one 5-oxides.

Pudziuvelyte E, Ríos-Luci C, León LG, Cikotiene I, Padrón JM.

Bioorg Med Chem. 2009 Jul 15;17(14):4955-60. doi: 10.1016/j.bmc.2009.05.078. Epub 2009 Jun 6.

PMID:
19527934
[PubMed - indexed for MEDLINE]
5.

Diarylureas and diarylamides with pyrrolo[2,3-d]pyrimidine scaffold as broad-spectrum anticancer agents.

El-Gamal MI, Oh CH.

Chem Pharm Bull (Tokyo). 2014;62(1):25-34.

PMID:
24390490
[PubMed - indexed for MEDLINE]
Free Article
6.

Novel water-soluble substituted pyrrolo[3,2-d]pyrimidines: design, synthesis, and biological evaluation as antitubulin antitumor agents.

Gangjee A, Pavana RK, Li W, Hamel E, Westbrook C, Mooberry SL.

Pharm Res. 2012 Nov;29(11):3033-9. doi: 10.1007/s11095-012-0816-3. Epub 2012 Jul 20.

PMID:
22814902
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Antitumor activity of novel pyrrolo[2,3-d]pyrimidin-4-ones.

Atapour-Mashhad H, Tayarani-Najaran Z, Davoodnia A, Moloudi R, Mousavi SH.

Drug Chem Toxicol. 2011 Jul;34(3):271-6. doi: 10.3109/01480545.2010.545066.

PMID:
21649481
[PubMed - indexed for MEDLINE]
9.

An unexpected Dimroth rearrangement leading to annelated thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidines with potent antitumor activity.

Lauria A, Patella C, Abbate I, Martorana A, Almerico AM.

Eur J Med Chem. 2013 Jul;65:381-8. doi: 10.1016/j.ejmech.2013.05.012. Epub 2013 May 20.

PMID:
23747807
[PubMed - indexed for MEDLINE]
10.

Synthesis of novel pyrrole and pyrrolo[2,3-d]pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents.

Ghorab MM, Ragab FA, Heiba HI, Youssef HA, El-Gazzar MG.

Bioorg Med Chem Lett. 2010 Nov 1;20(21):6316-20. doi: 10.1016/j.bmcl.2010.08.005. Epub 2010 Aug 7.

PMID:
20850308
[PubMed - indexed for MEDLINE]
11.

Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.

Shanab K, Schirmer E, Wulz E, Weissenbacher B, Lassnig S, Slanz R, Fösleitner G, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.

Bioorg Med Chem Lett. 2011 May 15;21(10):3117-21. doi: 10.1016/j.bmcl.2011.03.013. Epub 2011 Mar 30.

PMID:
21458262
[PubMed - indexed for MEDLINE]
12.

Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.

Shanab K, Schirmer E, Knafl H, Wulz E, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3950-2. doi: 10.1016/j.bmcl.2010.05.003. Epub 2010 May 7.

PMID:
20537894
[PubMed - indexed for MEDLINE]
13.
15.

2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance.

Gangjee A, Namjoshi OA, Keller SN, Smith CD.

Bioorg Med Chem. 2011 Jul 15;19(14):4355-65. doi: 10.1016/j.bmc.2011.05.030. Epub 2011 May 23.

PMID:
21680190
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities.

Abou El Ella DA, Ghorab MM, Noaman E, Heiba HI, Khalil AI.

Bioorg Med Chem. 2008 Mar 1;16(5):2391-402. Epub 2007 Nov 29.

PMID:
18086527
[PubMed - indexed for MEDLINE]
17.

Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines.

Pudlo JS, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB.

J Med Chem. 1990 Jul;33(7):1984-92.

PMID:
2163454
[PubMed - indexed for MEDLINE]
18.

Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors.

Gangjee A, Kurup S, Smith CD.

Bioorg Med Chem. 2013 Mar 1;21(5):1180-9. doi: 10.1016/j.bmc.2012.12.029. Epub 2013 Jan 3.

PMID:
23352482
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.

Gangjee A, Vidwans A, Elzein E, McGuire JJ, Queener SF, Kisliuk RL.

J Med Chem. 2001 Jun 7;44(12):1993-2003.

PMID:
11384244
[PubMed - indexed for MEDLINE]

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