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Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.

Nemoto S, Taguchi K, Matsumoto T, Kamata K, Kobayashi T.

Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H893-902. doi: 10.1152/ajpheart.01128.2011. Epub 2012 Aug 10.


Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ET(A)-receptor expression.

Nemoto S, Taguchi K, Matsumoto T, Kamata K, Kobayashi T.

Peptides. 2012 Jan;33(1):109-19. doi: 10.1016/j.peptides.2011.11.018. Epub 2011 Nov 28.


Pravastatin normalizes endothelium-derived contracting factor-mediated response via suppression of Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat.

Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T.

Acta Physiol (Oxf). 2012 Jun;205(2):255-65. doi: 10.1111/j.1748-1716.2011.02403.x. Epub 2012 Jan 17.


Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats.

Nemoto S, Kobayashi T, Taguchi K, Matsumoto T, Kamata K.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2383-94. doi: 10.1152/ajpheart.00178.2011. Epub 2011 Sep 16.


Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.

Matsumoto T, Ishida K, Nakayama N, Kobayashi T, Kamata K.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. doi: 10.1152/ajpheart.00043.2009. Epub 2009 Mar 13.


Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes.

Matsumoto T, Nakayama N, Ishida K, Kobayashi T, Kamata K.

J Pharmacol Exp Ther. 2009 Apr;329(1):324-34. doi: 10.1124/jpet.108.148718. Epub 2009 Jan 22.


Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin.

Kajikuri J, Watanabe Y, Ito Y, Ito R, Yamamoto T, Itoh T.

Br J Pharmacol. 2009 Sep;158(2):621-32. doi: 10.1111/j.1476-5381.2009.00348.x. Epub 2009 Jul 23.


Aortic superoxide production at the early hyperglycemic stage in a rat type 2 diabetes model and the effects of pravastatin.

Kikuchi C, Kajikuri J, Hori E, Nagami C, Matsunaga T, Kimura K, Itoh T.

Biol Pharm Bull. 2014;37(6):996-1002. Epub 2014 Apr 4.


Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.

Kim YH, Kim YS, Park CH, Chung IY, Yoo JM, Kim JG, Lee BJ, Kang SS, Cho GJ, Choi WS.

Diabetes. 2008 Aug;57(8):2181-90. doi: 10.2337/db07-1431. Epub 2008 Apr 28.


Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK.

Kobayashi T, Nogami T, Taguchi K, Matsumoto T, Kamata K.

Br J Pharmacol. 2008 Dec;155(7):974-83. doi: 10.1038/bjp.2008.327. Epub 2008 Aug 18.


Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model.

Yu Y, Ohmori K, Chen Y, Sato C, Kiyomoto H, Shinomiya K, Takeuchi H, Mizushige K, Kohno M.

J Am Coll Cardiol. 2004 Aug 18;44(4):904-13.


Mechanisms underlying altered extracellular nucleotide-induced contractions in mesenteric arteries from rats in later-stage type 2 diabetes: effect of ANG II type 1 receptor antagonism.

Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1850-61. doi: 10.1152/ajpheart.00502.2011. Epub 2011 Aug 19.


Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes.

Matsumoto T, Noguchi E, Ishida K, Kobayashi T, Yamada N, Kamata K.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1165-H1176. doi: 10.1152/ajpheart.00486.2008. Epub 2008 Jul 18.


FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2.

Lee HY, Youn SW, Cho HJ, Kwon YW, Lee SW, Kim SJ, Park YB, Oh BH, Kim HS.

Cardiovasc Res. 2013 Jan 1;97(1):143-52. doi: 10.1093/cvr/cvs283. Epub 2012 Sep 21.


Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

Matsumoto T, Kobayashi T, Kamata K.

Eur J Pharmacol. 2006 May 24;538(1-3):132-40. Epub 2006 Apr 15.


The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway.

Lobato NS, Neves KB, Filgueira FP, Fortes ZB, Carvalho MH, Webb RC, Oliveira AM, Tostes RC.

Life Sci. 2012 Oct 15;91(13-14):600-6. doi: 10.1016/j.lfs.2012.04.013. Epub 2012 Apr 13.

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