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Results: 1 to 20 of 97

1.

Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.

Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY.

Neuron. 2012 Aug 9;75(3):425-36. doi: 10.1016/j.neuron.2012.03.043.

PMID:
22884327
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Critical role for hypothalamic mTOR activity in energy balance.

Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG Jr, Guan KL.

Cell Metab. 2009 Apr;9(4):362-74. doi: 10.1016/j.cmet.2009.03.005.

PMID:
19356717
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009.

PMID:
19759305
[PubMed - indexed for MEDLINE]
Free Article
4.

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ.

Diabetes. 2011 Mar;60(3):735-45. doi: 10.2337/db10-1055. Epub 2011 Jan 24.

PMID:
21266325
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.

PMID:
16794735
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.

PMID:
17671657
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.

Varela L, Martínez-Sánchez N, Gallego R, Vázquez MJ, Roa J, Gándara M, Schoenmakers E, Nogueiras R, Chatterjee K, Tena-Sempere M, Diéguez C, López M.

J Pathol. 2012 Jun;227(2):209-22. doi: 10.1002/path.3984. Epub 2012 Feb 17.

PMID:
22294347
[PubMed - indexed for MEDLINE]
8.

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides.

Shimokawa T, Kumar MV, Lane MD.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):66-71. Epub 2001 Dec 26.

PMID:
11756683
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats.

Gyte A, Pritchard LE, Jones HB, Brennand JC, White A.

J Neuroendocrinol. 2007 Dec;19(12):941-51.

PMID:
18001323
[PubMed - indexed for MEDLINE]
10.

Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice.

Swart I, Jahng JW, Overton JM, Houpt TA.

Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1020-6.

PMID:
12376393
[PubMed - indexed for MEDLINE]
11.

5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus.

Hisadome K, Smith MA, Choudhury AI, Claret M, Withers DJ, Ashford ML.

Neuroscience. 2009 Mar 3;159(1):83-93. doi: 10.1016/j.neuroscience.2008.12.003. Epub 2008 Dec 14.

PMID:
19135134
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964.

PMID:
18382766
[PubMed - indexed for MEDLINE]
Free PMC Article
13.
14.

Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons.

Roepke TA, Smith AW, Rønnekleiv OK, Kelly MJ.

Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1399-406. doi: 10.1152/ajpendo.00565.2011. Epub 2012 Mar 20.

PMID:
22436698
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice.

Arens J, Moar KM, Eiden S, Weide K, Schmidt I, Mercer JG, Simon E, Korf HW.

Physiol Genomics. 2003 Dec 16;16(1):38-46.

PMID:
14559977
[PubMed - indexed for MEDLINE]
16.

Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females.

Qiu J, Xue C, Bosch MA, Murphy JG, Fan W, Rønnekleiv OK, Kelly MJ.

Mol Pharmacol. 2007 Oct;72(4):885-96. Epub 2007 Jul 10.

PMID:
17622577
[PubMed - indexed for MEDLINE]
Free Article
17.

Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.

Sousa-Ferreira L, Álvaro AR, Aveleira C, Santana M, Brandão I, Kügler S, de Almeida LP, Cavadas C.

PLoS One. 2011 May 11;6(5):e19745. doi: 10.1371/journal.pone.0019745.

PMID:
21589937
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.

Weston MC, Chen H, Swann JW.

J Neurosci. 2012 Aug 15;32(33):11441-52. doi: 10.1523/JNEUROSCI.1283-12.2012.

PMID:
22895726
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways.

Wang JH, Wang F, Yang MJ, Yu DF, Wu WN, Liu J, Ma LQ, Cai F, Chen JG.

Neuroscience. 2008 Sep 22;156(1):89-98. doi: 10.1016/j.neuroscience.2008.04.079. Epub 2008 Jun 5.

PMID:
18588949
[PubMed - indexed for MEDLINE]
20.

Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain.

Itateyama E, Chiba S, Sakata T, Yoshimatsu H.

Exp Biol Med (Maywood). 2003 Nov;228(10):1132-7.

PMID:
14610251
[PubMed - indexed for MEDLINE]

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