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Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background.

Lau M, Tsantikos E, Maxwell MJ, Tarlinton DM, Anderson GP, Hibbs ML.

J Autoimmun. 2012 Dec;39(4):388-97. doi: 10.1016/j.jaut.2012.06.003. Epub 2012 Aug 4.


Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6.

Tsantikos E, Oracki SA, Quilici C, Anderson GP, Tarlinton DM, Hibbs ML.

J Immunol. 2010 Feb 1;184(3):1348-60. doi: 10.4049/jimmunol.0901878. Epub 2009 Dec 30.


Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity.

Beavitt SJ, Harder KW, Kemp JM, Jones J, Quilici C, Casagranda F, Lam E, Turner D, Brennan S, Sly PD, Tarlinton DM, Anderson GP, Hibbs ML.

J Immunol. 2005 Aug 1;175(3):1867-75.


Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL.

J Immunol. 2014 Feb 1;192(3):875-85. doi: 10.4049/jimmunol.1300683. Epub 2013 Dec 30.


STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination.

Linehan LA, Warren WD, Thompson PA, Grusby MJ, Berton MT.

J Immunol. 1998 Jul 1;161(1):302-10.


IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.

Gutierrez T, Mayeux JM, Ortega SB, Karandikar NJ, Li QZ, Rakheja D, Zhou XJ, Satterthwaite AB.

Eur J Immunol. 2013 Feb;43(2):382-93. doi: 10.1002/eji.201142095. Epub 2012 Dec 18.


B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.

Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):E823-32. doi: 10.1073/pnas.1107913108. Epub 2011 Sep 12.


Genetic evidence for Lyn as a negative regulator of IL-4 signaling.

Janas ML, Hodgkin P, Hibbs M, Tarlinton D.

J Immunol. 1999 Oct 15;163(8):4192-8.


B cell-specific loss of Lyn kinase leads to autoimmunity.

Lamagna C, Hu Y, DeFranco AL, Lowell CA.

J Immunol. 2014 Feb 1;192(3):919-28. doi: 10.4049/jimmunol.1301979. Epub 2013 Dec 27.


Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions.

Burgis S, Gessner A.

Int Arch Allergy Immunol. 2007;143(4):263-8. Epub 2007 Mar 9.


Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.

Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN.

Nature. 1996 Apr 18;380(6575):630-3.


STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells.

Miyata S, Matsuyama T, Kodama T, Nishioka Y, Kuribayashi K, Takeda K, Akira S, Sugita M.

Clin Exp Allergy. 1999 Jan;29(1):114-23.


Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice.

Tsantikos E, Quilici C, Harder KW, Wang B, Zhu HJ, Anderson GP, Tarlinton DM, Hibbs ML.

J Immunol. 2009 Aug 15;183(4):2484-94. doi: 10.4049/jimmunol.0804346. Epub 2009 Jul 20.


The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3.

Mari N, Hercor M, Denanglaire S, Leo O, Andris F.

Eur J Immunol. 2013 Jun;43(6):1489-98. doi: 10.1002/eji.201242938. Epub 2013 Apr 19.


Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.

Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR.

Cell. 1995 Oct 20;83(2):301-11.


CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice.

Oracki SA, Tsantikos E, Quilici C, Light A, Schmidt T, Lew AM, Martin JE, Smith KG, Hibbs ML, Tarlinton DM.

J Immunol. 2010 Jan 15;184(2):757-63. doi: 10.4049/jimmunol.0804349. Epub 2009 Dec 4.


Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice.

Gutierrez T, Halcomb KE, Coughran AJ, Li QZ, Satterthwaite AB.

Eur J Immunol. 2010 Jul;40(7):1897-905. doi: 10.1002/eji.200940043.


A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.

Hasegawa M, Fujimoto M, Poe JC, Steeber DA, Lowell CA, Tedder TF.

J Immunol. 2001 Sep 1;167(5):2469-78.


NFATc1 deletion in T lymphocytes inhibits the allergic trait in a murine model of asthma.

Koch S, Reppert S, Finotto S.

Clin Exp Allergy. 2015 Aug;45(8):1356-66. doi: 10.1111/cea.12493.

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