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Results: 1 to 20 of 99

1.

Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.

Stelniec-Klotz I, Legewie S, Tchernitsa O, Witzel F, Klinger B, Sers C, Herzel H, Blüthgen N, Schäfer R.

Mol Syst Biol. 2012;8:601. doi: 10.1038/msb.2012.32.

PMID:
22864383
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.

Tchernitsa OI, Sers C, Zuber J, Hinzmann B, Grips M, Schramme A, Lund P, Schwendel A, Rosenthal A, Schäfer R.

Oncogene. 2004 Jun 3;23(26):4536-55.

PMID:
15064704
[PubMed - indexed for MEDLINE]
3.

Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.

Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL.

Am J Pathol. 2010 Sep;177(3):1503-13. doi: 10.2353/ajpath.2010.090651. Epub 2010 Jul 16.

PMID:
20639455
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells.

Venkatesan N, Krishnakumar S, Deepa PR, Deepa M, Khetan V, Reddy MA.

Mol Vis. 2012;18:2420-37. Epub 2012 Oct 3.

PMID:
23077401
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.

Lawrenson K, Sproul D, Grun B, Notaridou M, Benjamin E, Jacobs IJ, Dafou D, Sims AH, Gayther SA.

Carcinogenesis. 2011 Oct;32(10):1540-9. doi: 10.1093/carcin/bgr140. Epub 2011 Aug 22.

PMID:
21859834
[PubMed - indexed for MEDLINE]
Free Article
6.

Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells.

Wang Y, Ngo VN, Marani M, Yang Y, Wright G, Staudt LM, Downward J.

Oncogene. 2010 Aug 19;29(33):4658-70. doi: 10.1038/onc.2010.218. Epub 2010 Jun 21.

PMID:
20562906
[PubMed - indexed for MEDLINE]
7.

Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.

Lo Ré AE, Fernández-Barrena MG, Almada LL, Mills LD, Elsawa SF, Lund G, Ropolo A, Molejon MI, Vaccaro MI, Fernandez-Zapico ME.

J Biol Chem. 2012 Jul 20;287(30):25325-34. doi: 10.1074/jbc.M112.370809. Epub 2012 Apr 25.

PMID:
22535956
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.

Steckel M, Molina-Arcas M, Weigelt B, Marani M, Warne PH, Kuznetsov H, Kelly G, Saunders B, Howell M, Downward J, Hancock DC.

Cell Res. 2012 Aug;22(8):1227-45. doi: 10.1038/cr.2012.82. Epub 2012 May 22.

PMID:
22613949
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

MicroRNA let-7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K-Ras and HMGA2 gene expression.

Wang YY, Ren T, Cai YY, He XY.

Cancer Biother Radiopharm. 2013 Mar;28(2):131-7. doi: 10.1089/cbr.2012.1307. Epub 2012 Nov 7.

PMID:
23134218
[PubMed - indexed for MEDLINE]
10.

Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma.

Jazaeri AA, Bryant JL, Park H, Li H, Dahiya N, Stoler MH, Ferriss JS, Dutta A.

Neoplasia. 2011 Oct;13(10):899-911.

PMID:
22028616
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

HMGA2 gene is a promising target for ovarian cancer silencing therapy.

Malek A, Bakhidze E, Noske A, Sers C, Aigner A, Schäfer R, Tchernitsa O.

Int J Cancer. 2008 Jul 15;123(2):348-56. doi: 10.1002/ijc.23491.

PMID:
18452175
[PubMed - indexed for MEDLINE]
12.

Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells.

Sudhir PR, Chen CH, Pavana Kumari M, Wang MJ, Tsou CC, Sung TY, Chen JY, Chen CH.

Mol Cell Proteomics. 2012 Oct;11(10):901-15. Epub 2012 Jul 3.

PMID:
22761399
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.

Yea S, Narla G, Zhao X, Garg R, Tal-Kremer S, Hod E, Villanueva A, Loke J, Tarocchi M, Akita K, Shirasawa S, Sasazuki T, Martignetti JA, Llovet JM, Friedman SL.

Gastroenterology. 2008 May;134(5):1521-31. doi: 10.1053/j.gastro.2008.02.015. Epub 2008 Feb 13. Erratum in: Gastroenterology. 2008 Jul;135(1):326.

PMID:
18471523
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer.

Seth R, Crook S, Ibrahem S, Fadhil W, Jackson D, Ilyas M.

Gut. 2009 Sep;58(9):1234-41. doi: 10.1136/gut.2008.159137. Epub 2009 May 26.

PMID:
19474002
[PubMed - indexed for MEDLINE]
15.

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, Toftgård R.

Nat Struct Mol Biol. 2010 Jun;17(6):718-25. doi: 10.1038/nsmb.1833. Epub 2010 May 30.

PMID:
20512148
[PubMed - indexed for MEDLINE]
16.

Colorectal tumors are effectively eradicated by combined inhibition of {beta}-catenin, KRAS, and the oncogenic transcription factor ITF2.

Mologni L, Dekhil H, Ceccon M, Purgante S, Lan C, Cleris L, Magistroni V, Formelli F, Gambacorti-Passerini CB.

Cancer Res. 2010 Sep 15;70(18):7253-63. doi: 10.1158/0008-5472.CAN-10-1108. Epub 2010 Sep 7.

PMID:
20823162
[PubMed - indexed for MEDLINE]
Free Article
17.

RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.

Mei FC, Young TW, Liu J, Cheng X.

FASEB J. 2006 Mar;20(3):497-9. Epub 2005 Dec 29.

PMID:
16384911
[PubMed - indexed for MEDLINE]
Free Article
18.

Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry.

Young TW, Mei FC, Yang G, Thompson-Lanza JA, Liu J, Cheng X.

Cancer Res. 2004 Jul 1;64(13):4577-84.

PMID:
15231669
[PubMed - indexed for MEDLINE]
Free Article
19.

Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.

Park SW, Davison JM, Rhee J, Hruban RH, Maitra A, Leach SD.

Gastroenterology. 2008 Jun;134(7):2080-90. doi: 10.1053/j.gastro.2008.02.084. Epub 2008 Mar 5.

PMID:
18549880
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Biology of Krüppel-like factor 6 transcriptional regulator in cell life and death.

Andreoli V, Gehrau RC, Bocco JL.

IUBMB Life. 2010 Dec;62(12):896-905. doi: 10.1002/iub.396. Review.

PMID:
21154818
[PubMed - indexed for MEDLINE]

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