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Items: 1 to 20 of 237


Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells.

Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A.

PLoS One. 2012;7(6):e40148. doi: 10.1371/journal.pone.0040148. Epub 2012 Jun 28.


The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin.

Metalli D, Lovat F, Tripodi F, Genua M, Xu SQ, Spinelli M, Alberghina L, Vanoni M, Baffa R, Gomella LG, Iozzo RV, Morrione A.

Am J Pathol. 2010 Jun;176(6):2997-3006. doi: 10.2353/ajpath.2010.090904. Epub 2010 Apr 15.


The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling.

Li M, Yin Y, Hua H, Sun X, Luo T, Wang J, Jiang Y.

J Biol Chem. 2010 Oct 1;285(40):30480-8. doi: 10.1074/jbc.M110.131698. Epub 2010 Jul 29.


Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility.

Mañes S, Mira E, Gómez-Mouton C, Zhao ZJ, Lacalle RA, Martínez-A C.

Mol Cell Biol. 1999 Apr;19(4):3125-35.


Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration.

Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross RS.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H627-38. doi: 10.1152/ajpheart.00444.2008. Epub 2009 Jan 9.


B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.

Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.

J Biol Chem. 2009 Aug 21;284(34):22865-77. doi: 10.1074/jbc.M109.013169. Epub 2009 Jun 26.


(alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.

Sekimoto H, Eipper-Mains J, Pond-Tor S, Boney CM.

Mol Endocrinol. 2005 Jul;19(7):1859-67. Epub 2005 Mar 10.


Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.

Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, Richardson P, Munshi NC, Kahn CR, Mitsiades C, Anderson KC.

Cancer Res. 2003 Sep 15;63(18):5850-8. Erratum in: Cancer Res. 2003 Nov 1;63(21):7543.


Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.

Iozzo RV, Buraschi S, Genua M, Xu SQ, Solomides CC, Peiper SC, Gomella LG, Owens RC, Morrione A.

J Biol Chem. 2011 Oct 7;286(40):34712-21. doi: 10.1074/jbc.M111.262766. Epub 2011 Aug 12.


Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation.

Sun CK, Man K, Ng KT, Ho JW, Lim ZX, Cheng Q, Lo CM, Poon RT, Fan ST.

Carcinogenesis. 2008 Nov;29(11):2096-105. doi: 10.1093/carcin/bgn203. Epub 2008 Sep 1.


Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex.

Monami G, Gonzalez EM, Hellman M, Gomella LG, Baffa R, Iozzo RV, Morrione A.

Cancer Res. 2006 Jul 15;66(14):7103-10.


Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.

Mur C, Valverde AM, Kahn CR, Benito M.

Diabetes. 2002 Mar;51(3):743-54.

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