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Items: 1 to 20 of 86

1.

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY.

Genes Dev. 2012 Aug 15;26(16):1780-96. doi: 10.1101/gad.193789.112. Epub 2012 Aug 1.

2.

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.

Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY.

Nat Neurosci. 2015 Sep;18(9):1236-46. doi: 10.1038/nn.4088. Epub 2015 Aug 10.

3.

A sustained increase in the intracellular Ca²⁺ concentration induces proteolytic cleavage of EAG2 channel.

Shimizu N, Sato N, Kikuchi T, Ishizaki T, Kobayashi K, Kita K, Takimoto K.

Int J Biochem Cell Biol. 2015 Feb;59:126-34. doi: 10.1016/j.biocel.2014.12.007. Epub 2014 Dec 24.

PMID:
25542181
4.

Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma.

Lau KM, Chan QK, Pang JC, Ma FM, Li KK, Yeung WW, Cheng AS, Feng H, Chung NY, Li HM, Zhou L, Wang Y, Mao Y, Ng HK.

Acta Neuropathol. 2012 Apr;123(4):553-71. doi: 10.1007/s00401-011-0934-8. Epub 2012 Jan 17.

PMID:
22249617
5.

Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells.

Furukawa T, Tanji E, Kuboki Y, Hatori T, Yamamoto M, Shimizu K, Shibata N, Shiratori K.

Mol Cancer. 2012 Dec 10;11:88. doi: 10.1186/1476-4598-11-88.

6.

IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.

Borowiec AS, Hague F, Harir N, Guénin S, Guerineau F, Gouilleux F, Roudbaraki M, Lassoued K, Ouadid-Ahidouch H.

J Cell Physiol. 2007 Sep;212(3):690-701.

PMID:
17520698
7.

Differential expression of potassium ion channels in human renal cell carcinoma.

Wadhwa S, Wadhwa P, Dinda AK, Gupta NP.

Int Urol Nephrol. 2009;41(2):251-7. doi: 10.1007/s11255-008-9459-z. Epub 2008 Sep 8.

PMID:
18777199
8.

Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex.

Saganich MJ, Vega-Saenz de Miera E, Nadal MS, Baker H, Coetzee WA, Rudy B.

J Neurosci. 1999 Dec 15;19(24):10789-802.

9.

MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma.

Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Vecchio LD, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M.

PLoS One. 2009;4(3):e4998. doi: 10.1371/journal.pone.0004998. Epub 2009 Mar 24.

10.

MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma.

de Antonellis P, Medaglia C, Cusanelli E, Andolfo I, Liguori L, De Vita G, Carotenuto M, Bello A, Formiggini F, Galeone A, De Rosa G, Virgilio A, Scognamiglio I, Sciro M, Basso G, Schulte JH, Cinalli G, Iolascon A, Zollo M.

PLoS One. 2011;6(9):e24584. doi: 10.1371/journal.pone.0024584. Epub 2011 Sep 12.

11.
12.

Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.

Kawabata T, Tanimura S, Asai K, Kawasaki R, Matsumaru Y, Kohno M.

J Biol Chem. 2012 Mar 23;287(13):10289-300. doi: 10.1074/jbc.M111.319426. Epub 2012 Jan 23.

13.

Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications.

Menéndez ST, Villaronga MA, Rodrigo JP, Alvarez-Teijeiro S, García-Carracedo D, Urdinguio RG, Fraga MF, Pardo LA, Viloria CG, Suárez C, García-Pedrero JM.

J Mol Med (Berl). 2012 Oct;90(10):1173-84. doi: 10.1007/s00109-012-0893-0. Epub 2012 Mar 31.

PMID:
22466864
14.

Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration.

Afrasiabi E, Hietamäki M, Viitanen T, Sukumaran P, Bergelin N, Törnquist K.

Cell Signal. 2010 Jan;22(1):57-64. doi: 10.1016/j.cellsig.2009.09.010. Epub 2009 Sep 15.

PMID:
19765650
15.

Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia.

de Oliveira RM, Martin S, de Oliveira CL, Milani H, Schiavon AP, Joca S, Pardo LA, Stühmer W, Del Bel EA.

J Neurosci Res. 2012 Mar;90(3):632-40. doi: 10.1002/jnr.22772. Epub 2011 Oct 18.

PMID:
22006722
16.

Erg channel is critical in controlling cell volume during cell cycle in embryonic stem cells.

Abdelhady S, Kitambi SS, Lundin V, Aufschnaiter R, Sekyrova P, Sinha I, Lundgren KT, Castelo-Branco G, Linnarsson S, Wedlich-Söldner R, Teixeira A, Andäng M.

PLoS One. 2013 Aug 2;8(8):e72409. doi: 10.1371/journal.pone.0072409. Print 2013. Erratum in: PLoS One. 2014;9(3):e90271.

17.

The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancy.

Li Y, Lal B, Kwon S, Fan X, Saldanha U, Reznik TE, Kuchner EB, Eberhart C, Laterra J, Abounader R.

Cancer Res. 2005 Oct 15;65(20):9355-62.

18.

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.

Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R, Kroemer G.

Oncogene. 2004 May 27;23(25):4353-61.

PMID:
15048074
19.

p38 MAPK regulates the expression of ether à go-go potassium channel in human osteosarcoma cells.

Wu X, Zhong D, Lin B, Zhai W, Ding Z, Wu J.

Radiol Oncol. 2013 Mar;47(1):42-9. doi: 10.2478/v10019-012-0043-x. Epub 2013 Feb 1.

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