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Items: 1 to 20 of 90


A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation.

Radi M, Evensen L, Dreassi E, Zamperini C, Caporicci M, Falchi F, Musumeci F, Schenone S, Lorens JB, Botta M.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. doi: 10.1016/j.bmcl.2012.07.014. Epub 2012 Jul 13.


SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.

Cao ZX, Zheng RL, Lin HJ, Luo SD, Zhou Y, Xu YZ, Zeng XX, Wang Z, Zhou LN, Mao YQ, Yang L, Wei YQ, Yu LT, Yang SY, Zhao YL.

Cell Physiol Biochem. 2011;27(5):565-74. doi: 10.1159/000329978. Epub 2011 Jun 15.


Antiangiogenic mechanisms of PJ-8, a novel inhibitor of vascular endothelial growth factor receptor signaling.

Huang SW, Lien JC, Kuo SC, Huang TF.

Carcinogenesis. 2012 May;33(5):1022-30. doi: 10.1093/carcin/bgs127. Epub 2012 Mar 20.


In-silico fragment-based identification of novel angiogenesis inhibitors.

Dakshanamurthy S, Kim M, Brown ML, Byers SW.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4551-6. Epub 2007 Jun 15.


Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay.

Cross LM, Cook MA, Lin S, Chen JN, Rubinstein AL.

Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):911-2. No abstract available.


Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants.

Crawford AD, Liekens S, Kamuhabwa AR, Maes J, Munck S, Busson R, Rozenski J, Esguerra CV, de Witte PA.

PLoS One. 2011 Feb 17;6(2):e14694. doi: 10.1371/journal.pone.0014694.


Anti-angiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo.

Zhong ZF, Hoi PM, Wu GS, Xu ZT, Tan W, Chen XP, Cui L, Wu T, Wang YT.

J Ethnopharmacol. 2012 Jun 1;141(2):721-7. doi: 10.1016/j.jep.2011.08.052. Epub 2011 Sep 3.


Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation.

Mu X, Shi W, Sun L, Li H, Jiang Z, Zhang L.

Molecules. 2012 Jun 5;17(6):6854-68. doi: 10.3390/molecules17066854.


Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity.

Zhong H, Wang D, Wang N, Rios Y, Huang H, Li S, Wu X, Lin S.

Cell Res. 2011 Jul;21(7):1080-7. doi: 10.1038/cr.2011.41. Epub 2011 Mar 22.


CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.

Ruggeri B, Singh J, Gingrich D, Angeles T, Albom M, Yang S, Chang H, Robinson C, Hunter K, Dobrzanski P, Jones-Bolin S, Pritchard S, Aimone L, Klein-Szanto A, Herbert JM, Bono F, Schaeffer P, Casellas P, Bourie B, Pili R, Isaacs J, Ator M, Hudkins R, Vaught J, Mallamo J, Dionne C.

Cancer Res. 2003 Sep 15;63(18):5978-91. Erratum in: Cancer Res. 2003 Nov 1;63(21):7543.


Mammalian tumor xenografts induce neovascularization in zebrafish embryos.

Nicoli S, Ribatti D, Cotelli F, Presta M.

Cancer Res. 2007 Apr 1;67(7):2927-31.


Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.

Tran TC, Sneed B, Haider J, Blavo D, White A, Aiyejorun T, Baranowski TC, Rubinstein AL, Doan TN, Dingledine R, Sandberg EM.

Cancer Res. 2007 Dec 1;67(23):11386-92.


A novel poly-naphthol compound ST104P suppresses angiogenesis by attenuating matrix metalloproteinase-2 expression in endothelial cells.

Ma YL, Lin SW, Fang HC, Chou KJ, Bee YS, Chu TH, Chang MC, Weng WT, Wu CY, Cho CL, Tai MH.

Int J Mol Sci. 2014 Sep 19;15(9):16611-27. doi: 10.3390/ijms150916611.


Synthesis and antiangiogenic activity of novel gambogic acid derivatives.

Chen T, Zhang RH, He SC, Xu QY, Ma L, Wang GC, Qiu N, Peng F, Chen JY, Qiu JX, Peng AH, Chen LJ.

Molecules. 2012 May 25;17(6):6249-68. doi: 10.3390/molecules17066249.


Transcriptional profiling of angiogenesis activities of calycosin in zebrafish.

Li S, Lou S, Lei BU, Chan TF, Kwan YW, Chan SW, Leung GP, Tsui SK, Lee SM.

Mol Biosyst. 2011 Nov;7(11):3112-21. doi: 10.1039/c1mb05206c. Epub 2011 Sep 12.


Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways.

Li X, Wang X, Ye H, Peng A, Chen L.

Cancer Chemother Pharmacol. 2012 Sep;70(3):425-37. doi: 10.1007/s00280-012-1923-x. Epub 2012 Jul 20.


Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway.

Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X.

J Pharmacol Exp Ther. 2011 Nov;339(2):403-11. doi: 10.1124/jpet.111.181891. Epub 2011 Aug 9.


Resveratrol derivative, trans-3,5,4'-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation.

Alex D, Leong EC, Zhang ZJ, Yan GT, Cheng SH, Leong CW, Li ZH, Lam KH, Chan SW, Lee SM.

J Cell Biochem. 2010 Feb 1;109(2):339-46. doi: 10.1002/jcb.22405.


Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades.

Lee JH, Choi S, Lee Y, Lee HJ, Kim KH, Ahn KS, Bae H, Lee HJ, Lee EO, Ahn KS, Ryu SY, Lü J, Kim SH.

Mol Cancer Ther. 2010 Feb;9(2):389-99. doi: 10.1158/1535-7163.MCT-09-0775. Epub 2010 Jan 26.


Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo.

Chan JY, Koon JC, Liu X, Detmar M, Yu B, Kong SK, Fung KP.

J Ethnopharmacol. 2011 Sep 1;137(1):64-9. doi: 10.1016/j.jep.2011.04.021. Epub 2011 May 31.

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