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Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis.

Xi C, Hu Y, Buckhaults P, Moskophidis D, Mivechi NF.

J Biol Chem. 2012 Oct 12;287(42):35646-57. doi: 10.1074/jbc.M112.377481. Epub 2012 Jul 30.


HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer.

Schulz R, Streller F, Scheel AH, Rüschoff J, Reinert MC, Dobbelstein M, Marchenko ND, Moll UM.

Cell Death Dis. 2014 Jan 2;5:e980. doi: 10.1038/cddis.2013.508.


The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.

Brantley-Sieders DM, Zhuang G, Hicks D, Fang WB, Hwang Y, Cates JM, Coffman K, Jackson D, Bruckheimer E, Muraoka-Cook RS, Chen J.

J Clin Invest. 2008 Jan;118(1):64-78.


The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.

Whelan KA, Schwab LP, Karakashev SV, Franchetti L, Johannes GJ, Seagroves TN, Reginato MJ.

J Biol Chem. 2013 May 31;288(22):15865-77. doi: 10.1074/jbc.M112.426999. Epub 2013 Apr 12.


CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling.

Lo PK, Kanojia D, Liu X, Singh UP, Berger FG, Wang Q, Chen H.

Oncogene. 2012 May 24;31(21):2614-26. doi: 10.1038/onc.2011.439. Epub 2011 Sep 26.


PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.

Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP.

Mol Cell Biol. 2002 Aug;22(15):5281-95.


CdGAP is required for transforming growth factor β- and Neu/ErbB-2-induced breast cancer cell motility and invasion.

He Y, Northey JJ, Primeau M, Machado RD, Trembath R, Siegel PM, Lamarche-Vane N.

Oncogene. 2011 Mar 3;30(9):1032-45. doi: 10.1038/onc.2010.477. Epub 2010 Nov 1.


Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.

Lee RJ, Albanese C, Fu M, D'Amico M, Lin B, Watanabe G, Haines GK 3rd, Siegel PM, Hung MC, Yarden Y, Horowitz JM, Muller WJ, Pestell RG.

Mol Cell Biol. 2000 Jan;20(2):672-83.


Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.

Kim A, Liu B, Ordonez-Ercan D, Alvarez KM, Jones LD, McKimmey C, Edgerton SM, Yang X, Thor AD.

Breast Cancer Res. 2005;7(5):R708-18. Epub 2005 Jul 6.


Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.

Dankort D, Maslikowski B, Warner N, Kanno N, Kim H, Wang Z, Moran MF, Oshima RG, Cardiff RD, Muller WJ.

Mol Cell Biol. 2001 Mar;21(5):1540-51.


Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells.

Leontovich AA, Zhang S, Quatraro C, Iankov I, Veroux PF, Gambino MW, Degnim A, McCubrey J, Ingle J, Galanis E, D'Assoro AB.

Int J Oncol. 2012 Jun;40(6):1858-64. doi: 10.3892/ijo.2012.1407. Epub 2012 Mar 19.


Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.

Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H, Grünert S.

J Cell Biol. 2002 Jan 21;156(2):299-313. Epub 2002 Jan 14.


Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.

Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, Fodstad O, Tan M.

Oncogene. 2009 Oct 22;28(42):3689-701. doi: 10.1038/onc.2009.229. Epub 2009 Aug 10.


N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties.

Qian X, Anzovino A, Kim S, Suyama K, Yao J, Hulit J, Agiostratidou G, Chandiramani N, McDaid HM, Nagi C, Cohen HW, Phillips GR, Norton L, Hazan RB.

Oncogene. 2014 Jun 26;33(26):3411-21. doi: 10.1038/onc.2013.310. Epub 2013 Aug 26.


Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.

Meng L, Gabai VL, Sherman MY.

Oncogene. 2010 Sep 16;29(37):5204-13. doi: 10.1038/onc.2010.277. Epub 2010 Jul 12.


Atorvastatin modulates anti-proliferative and pro-proliferative signals in Her2/neu-positive mammary cancer.

Riganti C, Pinto H, Bolli E, Belisario DC, Calogero RA, Bosia A, Cavallo F.

Biochem Pharmacol. 2011 Nov 1;82(9):1079-89. doi: 10.1016/j.bcp.2011.07.079. Epub 2011 Jul 23.


P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.

McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M, Chodosh LA, Gunther EJ, Hilsenbeck SG, Rosen JM, Vargo-Gogola T.

Breast Cancer Res. 2010;12(5):R73. doi: 10.1186/bcr2643. Epub 2010 Sep 22.


Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.

So JY, Wahler JE, Yoon T, Smolarek AK, Lin Y, Shih WJ, Maehr H, Uskokovic M, Liby KT, Sporn MB, Suh N.

Cancer Prev Res (Phila). 2013 Sep;6(9):959-70. doi: 10.1158/1940-6207.CAPR-13-0087. Epub 2013 Jul 15.

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