Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 122

1.

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.

Nature. 2012 Aug 16;488(7411):404-8. doi: 10.1038/nature11262.

PMID:
22842901
[PubMed - indexed for MEDLINE]
2.

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.

Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18439-44. Epub 2007 Nov 14.

PMID:
18003914
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.

Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng S, Che KH, Podoll J, Heightman TD, Oppermann U, Schreiber SL, Wang X.

J Am Chem Soc. 2011 Jun 22;133(24):9451-6. doi: 10.1021/ja201597b. Epub 2011 May 31.

PMID:
21585201
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A.

PLoS One. 2010 Nov 23;5(11):e15535. doi: 10.1371/journal.pone.0015535.

PMID:
21124847
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.

Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez ED.

Nat Commun. 2013;4:2035. doi: 10.1038/ncomms3035. Erratum in: Nat Commun. 2013;4:2639.

PMID:
23792809
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A new horizon for epigenetic medicine?

Chen S, Shi Y.

Cell Res. 2013 Mar;23(3):326-8. doi: 10.1038/cr.2012.136. Epub 2012 Sep 18.

PMID:
22986503
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structural insights into histone lysine demethylation.

Hou H, Yu H.

Curr Opin Struct Biol. 2010 Dec;20(6):739-48. doi: 10.1016/j.sbi.2010.09.006. Epub 2010 Oct 21. Review.

PMID:
20970991
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.

Chen S, Ma J, Wu F, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y.

Genes Dev. 2012 Jun 15;26(12):1364-75. doi: 10.1101/gad.186056.111.

PMID:
22713873
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.

Miller SA, Mohn SE, Weinmann AS.

Mol Cell. 2010 Nov 24;40(4):594-605. doi: 10.1016/j.molcel.2010.10.028.

PMID:
21095589
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.

Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C.

J Biol Chem. 2014 Jun 27;289(26):18302-13. doi: 10.1074/jbc.M114.555052. Epub 2014 May 5.

PMID:
24798337
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.

De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G.

Cell. 2007 Sep 21;130(6):1083-94. Epub 2007 Sep 6.

PMID:
17825402
[PubMed - indexed for MEDLINE]
Free Article
12.

Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors.

Lohse B, Nielsen AL, Kristensen JB, Helgstrand C, Cloos PA, Olsen L, Gajhede M, Clausen RP, Kristensen JL.

Angew Chem Int Ed Engl. 2011 Sep 19;50(39):9100-3. doi: 10.1002/anie.201101849. Epub 2011 Aug 25. No abstract available.

PMID:
21919140
[PubMed - indexed for MEDLINE]
13.

Identification of non-histone substrates for JMJD2A-C histone demethylases.

Ponnaluri VK, Vavilala DT, Putty S, Gutheil WG, Mukherji M.

Biochem Biophys Res Commun. 2009 Dec 11;390(2):280-4. doi: 10.1016/j.bbrc.2009.09.107. Epub 2009 Sep 30.

PMID:
19799855
[PubMed - indexed for MEDLINE]
14.

Comparative expression analysis of the H3K27 demethylases, JMJD3 and UTX, with the H3K27 methylase, EZH2, in Xenopus.

Kawaguchi A, Ochi H, Sudou N, Ogino H.

Int J Dev Biol. 2012;56(4):295-300. doi: 10.1387/ijdb.113360ak.

PMID:
22562205
[PubMed - indexed for MEDLINE]
Free Article
15.

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A.

J Med Chem. 2012 Jul 26;55(14):6639-43. doi: 10.1021/jm300677j. Epub 2012 Jul 11.

PMID:
22724510
[PubMed - indexed for MEDLINE]
16.

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.

Kristensen LH, Nielsen AL, Helgstrand C, Lees M, Cloos P, Kastrup JS, Helin K, Olsen L, Gajhede M.

FEBS J. 2012 Jun;279(11):1905-14. doi: 10.1111/j.1742-4658.2012.08567.x. Epub 2012 May 2.

PMID:
22420752
[PubMed - indexed for MEDLINE]
17.

Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.

Upadhyay AK, Horton JR, Zhang X, Cheng X.

Curr Opin Struct Biol. 2011 Dec;21(6):750-60. doi: 10.1016/j.sbi.2011.08.003. Epub 2011 Aug 25.

PMID:
21872465
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors.

Mulji A, Haslam C, Brown F, Randle R, Karamshi B, Smith J, Eagle R, Munoz-Muriedas J, Taylor J, Sheikh A, Bridges A, Gill K, Jepras R, Smee P, Barker M, Woodrow M, Liddle J, Thomas P, Jones E, Gordon L, Tanner R, Leveridge M, Hutchinson S, Martin M, Brown M, Kruidenier L, Katso R.

J Biomol Screen. 2012 Jan;17(1):108-20. doi: 10.1177/1087057111418229.

PMID:
22223398
[PubMed - indexed for MEDLINE]
19.

Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development.

Canovas S, Cibelli JB, Ross PJ.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2400-5. doi: 10.1073/pnas.1119112109. Epub 2012 Jan 30.

PMID:
22308433
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A histone H3 lysine 27 demethylase regulates animal posterior development.

Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.

Nature. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.

PMID:
17851529
[PubMed - indexed for MEDLINE]
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk