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Items: 1 to 20 of 259

1.

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes.

Dong B, Qi D, Yang L, Huang Y, Xiao X, Tai N, Wen L, Wong FS.

Am J Physiol Heart Circ Physiol. 2012 Sep 15;303(6):H732-42. doi: 10.1152/ajpheart.00948.2011. Epub 2012 Jul 27.

2.

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.

Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108. doi: 10.1152/ajpheart.00452.2009. Epub 2009 Oct 2.

3.

Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes.

Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton AA, Yuan WJ, Lin L.

Cardiovasc Res. 2013 Jun 1;98(3):391-401. doi: 10.1093/cvr/cvt047. Epub 2013 Feb 27.

4.

FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation.

Yan X, Chen J, Zhang C, Zhou S, Zhang Z, Chen J, Feng W, Li X, Tan Y.

J Cell Mol Med. 2015 Jul;19(7):1557-68. doi: 10.1111/jcmm.12530. Epub 2015 Mar 30.

5.

Acute diabetes moderates trafficking of cardiac lipoprotein lipase through p38 mitogen-activated protein kinase-dependent actin cytoskeleton organization.

Kim MS, Kewalramani G, Puthanveetil P, Lee V, Kumar U, An D, Abrahani A, Rodrigues B.

Diabetes. 2008 Jan;57(1):64-76. Epub 2007 Oct 17.

6.

Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury.

Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, Goujon JM, Ogier-Denis E, Vandewalle A.

Cell Death Differ. 2010 Sep;17(9):1474-85. doi: 10.1038/cdd.2010.26. Epub 2010 Mar 12.

7.

Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy.

Pulinilkunnil T, Kienesberger PC, Nagendran J, Waller TJ, Young ME, Kershaw EE, Korbutt G, Haemmerle G, Zechner R, Dyck JR.

Diabetes. 2013 May;62(5):1464-77. doi: 10.2337/db12-0927. Epub 2013 Jan 24.

8.

Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.

Ueno M, Suzuki J, Zenimaru Y, Takahashi S, Koizumi T, Noriki S, Yamaguchi O, Otsu K, Shen WJ, Kraemer FB, Miyamori I.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1109-18. doi: 10.1152/ajpendo.00016.2008. Epub 2008 Apr 15.

9.

Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice.

Gülden E, Ihira M, Ohashi A, Reinbeck AL, Freudenberg MA, Kolb H, Burkart V.

PLoS One. 2013 Sep 23;8(9):e75385. doi: 10.1371/journal.pone.0075385. eCollection 2013.

10.

Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes.

Devaraj S, Tobias P, Jialal I.

Cytokine. 2011 Sep;55(3):441-5. doi: 10.1016/j.cyto.2011.03.023. Epub 2011 Apr 16. Erratum in: Cytokine. 2011 Dec;56(3):832.

PMID:
21498084
11.

TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle.

Zbinden-Foncea H, Raymackers JM, Deldicque L, Renard P, Francaux M.

Med Sci Sports Exerc. 2012 Aug;44(8):1463-72. doi: 10.1249/MSS.0b013e31824e0d5d.

PMID:
22330023
12.

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways.

Gorina R, Font-Nieves M, Márquez-Kisinousky L, Santalucia T, Planas AM.

Glia. 2011 Feb;59(2):242-55. doi: 10.1002/glia.21094.

PMID:
21125645
13.

Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice.

Zhang J, Cheng Y, Gu J, Wang S, Zhou S, Wang Y, Tan Y, Feng W, Fu Y, Mellen N, Cheng R, Ma J, Zhang C, Li Z, Cai L.

Clin Sci (Lond). 2016 Apr;130(8):625-41. doi: 10.1042/CS20150623. Epub 2016 Jan 21.

PMID:
26795437
14.

Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia.

Fallach R, Shainberg A, Avlas O, Fainblut M, Chepurko Y, Porat E, Hochhauser E.

J Mol Cell Cardiol. 2010 Jun;48(6):1236-44. doi: 10.1016/j.yjmcc.2010.02.020. Epub 2010 Mar 4.

PMID:
20211628
15.

Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes.

Ramírez E, Klett-Mingo M, Ares-Carrasco S, Picatoste B, Ferrarini A, Rupérez FJ, Caro-Vadillo A, Barbas C, Egido J, Tuñón J, Lorenzo Ó.

Cardiovasc Diabetol. 2013 Nov 21;12:172. doi: 10.1186/1475-2840-12-172.

16.

p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation.

Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Okigaki M, Adachi S, Tanaka H, Takamatsu T, Matsubara H.

Circ Heart Fail. 2012 Jan;5(1):106-15. doi: 10.1161/CIRCHEARTFAILURE.111.961565. Epub 2011 Nov 9. Erratum in: Circ Heart Fail. 2014 Mar 1;7(2):383.

17.

Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes.

Huang TH, Yang Q, Harada M, Uberai J, Radford J, Li GQ, Yamahara J, Roufogalis BD, Li Y.

Toxicol Appl Pharmacol. 2006 Jan 1;210(1-2):78-85. Epub 2005 Aug 29.

PMID:
16129467
18.

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.

Palomer X, Salvadó L, Barroso E, Vázquez-Carrera M.

Int J Cardiol. 2013 Oct 9;168(4):3160-72. doi: 10.1016/j.ijcard.2013.07.150. Epub 2013 Aug 6. Review.

PMID:
23932046
19.

Acute dexamethasone-induced increase in cardiac lipoprotein lipase requires activation of both Akt and stress kinases.

Kewalramani G, Puthanveetil P, Kim MS, Wang F, Lee V, Hau N, Beheshti E, Ng N, Abrahani A, Rodrigues B.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E137-47. doi: 10.1152/ajpendo.00004.2008. Epub 2008 May 6.

20.

Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice.

Riad A, Jäger S, Sobirey M, Escher F, Yaulema-Riss A, Westermann D, Karatas A, Heimesaat MM, Bereswill S, Dragun D, Pauschinger M, Schultheiss HP, Tschöpe C.

J Immunol. 2008 May 15;180(10):6954-61.

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