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Items: 1 to 20 of 125

1.

Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL.

Dorababu P, Naushad SM, Linga VG, Gundeti S, Nagesh N, Kutala VK, Reddanna P, Digumarti R.

Pharmacogenomics. 2012 Jul;13(9):1001-8. doi: 10.2217/pgs.12.70.

PMID:
22838948
2.

Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.

Dorababu P, Nagesh N, Linga VG, Gundeti S, Kutala VK, Reddanna P, Digumarti R.

Eur J Clin Pharmacol. 2012 Apr;68(4):379-87. doi: 10.1007/s00228-011-1133-1. Epub 2011 Oct 19.

PMID:
22009189
3.

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia.

Farfan MJ, Salas C, Canales C, Silva F, Villarroel M, Kopp K, Torres JP, Santolaya ME, Morales J.

BMC Cancer. 2014 Apr 28;14:299. doi: 10.1186/1471-2407-14-299.

4.

Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer.

Naushad SM, Pavani A, Digumarti RR, Gottumukkala SR, Kutala VK.

Mol Biol Rep. 2011 Nov;38(8):4893-901. doi: 10.1007/s11033-010-0631-z. Epub 2010 Dec 14.

PMID:
21161404
5.

Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine.

Wan Rosalina WR, Teh LK, Mohamad N, Nasir A, Yusoff R, Baba AA, Salleh MZ.

J Clin Pharm Ther. 2012 Apr;37(2):237-41. doi: 10.1111/j.1365-2710.2011.01272.x. Epub 2011 May 5.

PMID:
21545474
6.

Thiopurine S-methyltransferase phenotype-genotype correlation in children with acute lymphoblastic leukemia.

Chrzanowska M, Kuehn M, Januszkiewicz-Lewandowska D, Kurzawski M, Droździk M.

Acta Pol Pharm. 2012 May-Jun;69(3):405-10.

7.

Influence of age, sex, and haplotypes of thiopurine methyltransferase (TPMT) gene on 6- mercaptopurine toxicity in children with acute lymphoblastic leukemia.

Uppugunduri CR, Ansari M.

Eur J Clin Pharmacol. 2012 May;68(5):887-8; author reply 885-6. doi: 10.1007/s00228-011-1185-2. Epub 2011 Dec 14. No abstract available.

PMID:
22166935
8.

Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis.

Peregud-Pogorzelski J, Tetera-Rudnicka E, Kurzawski M, Brodkiewicz A, Adrianowska N, Mlynarski W, Januszkiewicz D, Drozdzik M.

Pediatr Blood Cancer. 2011 Oct;57(4):578-82. doi: 10.1002/pbc.23013. Epub 2011 Feb 11.

PMID:
21319286
9.

Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.

Albayrak M, Konyssova U, Kaya Z, Gursel T, Guntekin S, Percin EF, Kocak U.

Cancer Chemother Pharmacol. 2011 Nov;68(5):1155-9. doi: 10.1007/s00280-011-1599-7. Epub 2011 Mar 13.

PMID:
21400026
11.

Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia.

Dokmanovic L, Urosevic J, Janic D, Jovanovic N, Petrucev B, Tosic N, Pavlovic S.

Ther Drug Monit. 2006 Dec;28(6):800-6.

PMID:
17164697
12.

Association between reduced folate carrier G80A polymorphism and methotrexate toxicity in childhood acute lymphoblastic leukemia: a meta-analysis.

He HR, Liu P, He GH, Dong WH, Wang MY, Dong YL, Lu J.

Leuk Lymphoma. 2014 Dec;55(12):2793-800. doi: 10.3109/10428194.2014.898761. Epub 2014 Apr 3.

PMID:
24597986
13.

Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: a possible association between survival rate and ITPA polymorphism.

Kim H, Kang HJ, Kim HJ, Jang MK, Kim NH, Oh Y, Han BD, Choi JY, Kim CW, Lee JW, Park KD, Shin HY, Ahn HS.

PLoS One. 2012;7(9):e45558. doi: 10.1371/journal.pone.0045558. Epub 2012 Sep 24.

14.

Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia.

Erčulj N, Kotnik BF, Debeljak M, Jazbec J, Dolžan V.

Leuk Lymphoma. 2012 Jun;53(6):1096-104. doi: 10.3109/10428194.2011.639880. Epub 2012 Feb 3.

PMID:
22074251
15.
16.

Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in Chinese ALL children and possible association with mercaptopurine related toxicity.

Ma X, Zheng J, Jin M, Li W, Gao C, Zhang D, Chen Y, Li X, Xie J.

Int J Clin Exp Pathol. 2014 Jun 15;7(7):4552-6. eCollection 2014.

17.

[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia].

Ma XL, Zhu P, Wu MY, Li ZG, Hu YM.

Zhonghua Er Ke Za Zhi. 2003 Dec;41(12):929-33. Chinese.

PMID:
14723818
18.

Association between SNPs in genes involved in folate metabolism and preterm birth risk.

Wang BJ, Liu MJ, Wang Y, Dai JR, Tao JY, Wang SN, Zhong N, Chen Y.

Genet Mol Res. 2015 Feb 2;14(1):850-9. doi: 10.4238/2015.February.2.9.

19.

Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.

Shimasaki N, Mori T, Torii C, Sato R, Shimada H, Tanigawara Y, Kosaki K, Takahashi T.

J Pediatr Hematol Oncol. 2008 May;30(5):347-52. doi: 10.1097/MPH.0b013e318165b25d.

PMID:
18458567
20.

Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression.

Patiño-García A, Zalacaín M, Marrodán L, San-Julián M, Sierrasesúmaga L.

J Pediatr. 2009 May;154(5):688-93. doi: 10.1016/j.jpeds.2008.11.030. Epub 2009 Jan 21.

PMID:
19159907
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