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Items: 1 to 20 of 140


Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.

Arita K, Isogai S, Oda T, Unoki M, Sugita K, Sekiyama N, Kuwata K, Hamamoto R, Tochio H, Sato M, Ariyoshi M, Shirakawa M.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12950-5. doi: 10.1073/pnas.1203701109. Epub 2012 Jul 25.


Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein.

Cheng J, Yang Y, Fang J, Xiao J, Zhu T, Chen F, Wang P, Li Z, Yang H, Xu Y.

J Biol Chem. 2013 Jan 11;288(2):1329-39. doi: 10.1074/jbc.M112.415398. Epub 2012 Nov 16.


UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail.

Xie S, Jakoncic J, Qian C.

J Mol Biol. 2012 Jan 13;415(2):318-28. doi: 10.1016/j.jmb.2011.11.012. Epub 2011 Nov 12.


The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.

Lallous N, Legrand P, McEwen AG, Ramón-Maiques S, Samama JP, Birck C.

PLoS One. 2011;6(11):e27599. doi: 10.1371/journal.pone.0027599. Epub 2011 Nov 11.


Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation.

Rothbart SB, Dickson BM, Ong MS, Krajewski K, Houliston S, Kireev DB, Arrowsmith CH, Strahl BD.

Genes Dev. 2013 Jun 1;27(11):1288-98. doi: 10.1101/gad.220467.113.


Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.

Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chédin F, Arrowsmith CH, Dhe-Paganon S.

J Biol Chem. 2011 Jul 8;286(27):24300-11. doi: 10.1074/jbc.M111.234104. Epub 2011 Apr 13.


Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation.

Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD.

Nat Struct Mol Biol. 2012 Nov;19(11):1155-60. doi: 10.1038/nsmb.2391. Epub 2012 Sep 30.


Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis.

Bronner C, Krifa M, Mousli M.

Biochem Pharmacol. 2013 Dec 15;86(12):1643-9. doi: 10.1016/j.bcp.2013.10.002. Epub 2013 Oct 14. Review.


Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.

Wang C, Shen J, Yang Z, Chen P, Zhao B, Hu W, Lan W, Tong X, Wu H, Li G, Cao C.

Cell Res. 2011 Sep;21(9):1379-82. doi: 10.1038/cr.2011.123. Epub 2011 Aug 2. No abstract available.


PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.

Rajakumara E, Wang Z, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y.

Mol Cell. 2011 Jul 22;43(2):275-84. doi: 10.1016/j.molcel.2011.07.006.


Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2.

Hu L, Li Z, Wang P, Lin Y, Xu Y.

Cell Res. 2011 Sep;21(9):1374-8. doi: 10.1038/cr.2011.124. Epub 2011 Aug 2. No abstract available.


The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation.

Chignola F, Gaetani M, Rebane A, Org T, Mollica L, Zucchelli C, Spitaleri A, Mannella V, Peterson P, Musco G.

Nucleic Acids Res. 2009 May;37(9):2951-61. doi: 10.1093/nar/gkp166. Epub 2009 Mar 17.


UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer.

Jin W, Chen L, Chen Y, Xu SG, Di GH, Yin WJ, Wu J, Shao ZM.

Breast Cancer Res Treat. 2010 Sep;123(2):359-73. doi: 10.1007/s10549-009-0652-2. Epub 2009 Nov 27.


The multi-domain protein Np95 connects DNA methylation and histone modification.

Rottach A, Frauer C, Pichler G, Bonapace IM, Spada F, Leonhardt H.

Nucleic Acids Res. 2010 Apr;38(6):1796-804. doi: 10.1093/nar/gkp1152. Epub 2009 Dec 21.


Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.

Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ.

Nature. 2006 Jul 6;442(7098):91-5. Epub 2006 May 21.


Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate.

Gelato KA, Tauber M, Ong MS, Winter S, Hiragami-Hamada K, Sindlinger J, Lemak A, Bultsma Y, Houliston S, Schwarzer D, Divecha N, Arrowsmith CH, Fischle W.

Mol Cell. 2014 Jun 19;54(6):905-19. doi: 10.1016/j.molcel.2014.04.004. Epub 2014 May 8.


Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1.

Yang N, Wang W, Wang Y, Wang M, Zhao Q, Rao Z, Zhu B, Xu RM.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17954-9. doi: 10.1073/pnas.1208517109. Epub 2012 Oct 17.


ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation.

Karagianni P, Amazit L, Qin J, Wong J.

Mol Cell Biol. 2008 Jan;28(2):705-17. Epub 2007 Oct 29.


Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.

Qiu Y, Liu L, Zhao C, Han C, Li F, Zhang J, Wang Y, Li G, Mei Y, Wu M, Wu J, Shi Y.

Genes Dev. 2012 Jun 15;26(12):1376-91. doi: 10.1101/gad.188359.112.

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