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Items: 1 to 20 of 91

1.

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse.

Jacobsen JP, Medvedev IO, Caron MG.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 5;367(1601):2444-59. doi: 10.1098/rstb.2012.0109. Review.

2.

Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.

Jacobsen JP, Siesser WB, Sachs BD, Peterson S, Cools MJ, Setola V, Folgering JH, Flik G, Caron MG.

Mol Psychiatry. 2012 Jul;17(7):694-704. doi: 10.1038/mp.2011.50. Epub 2011 May 3.

3.

Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress.

Sachs BD, Ni JR, Caron MG.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2557-62. doi: 10.1073/pnas.1416866112. Epub 2015 Feb 9.

4.

The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine.

Sachs BD, Jacobsen JP, Thomas TL, Siesser WB, Roberts WL, Caron MG.

Transl Psychiatry. 2013 Aug 13;3:e291. doi: 10.1038/tp.2013.65.

5.

Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency.

Dzirasa K, Kumar S, Sachs BD, Caron MG, Nicolelis MA.

J Neurosci. 2013 Mar 6;33(10):4505-13. doi: 10.1523/JNEUROSCI.4891-12.2013.

6.

Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice.

Sachs BD, Salahi AA, Caron MG.

Neuropharmacology. 2014 Feb;77:177-84. doi: 10.1016/j.neuropharm.2013.09.010. Epub 2013 Sep 22.

7.

Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.

Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S.

J Neurosci. 2006 Jan 11;26(2):530-4.

8.

Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification.

Gutknecht L, Araragi N, Merker S, Waider J, Sommerlandt FM, Mlinar B, Baccini G, Mayer U, Proft F, Hamon M, Schmitt AG, Corradetti R, Lanfumey L, Lesch KP.

PLoS One. 2012;7(8):e43157. doi: 10.1371/journal.pone.0043157. Epub 2012 Aug 17.

9.

Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.

Cervo L, Canetta A, Calcagno E, Burbassi S, Sacchetti G, Caccia S, Fracasso C, Albani D, Forloni G, Invernizzi RW.

J Neurosci. 2005 Sep 7;25(36):8165-72.

10.

Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency.

Beaulieu JM, Zhang X, Rodriguiz RM, Sotnikova TD, Cools MJ, Wetsel WC, Gainetdinov RR, Caron MG.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1333-8. doi: 10.1073/pnas.0711496105. Epub 2008 Jan 22.

11.

Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice.

Siesser WB, Sachs BD, Ramsey AJ, Sotnikova TD, Beaulieu JM, Zhang X, Caron MG, Gainetdinov RR.

ACS Chem Neurosci. 2013 Jan 16;4(1):84-8. doi: 10.1021/cn300127h. Epub 2012 Oct 1.

12.

Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety.

Jahanshahi A, Le Maitre E, Temel Y, Lanfumey L, Hamon M, Lesch KP, Tordera RM, Del Río J, Aso E, Maldonado R, Hökfelt T, Steinbusch HW.

J Chem Neuroanat. 2011 Jul;41(4):227-33. doi: 10.1016/j.jchemneu.2011.05.015. Epub 2011 Jun 15.

PMID:
21704153
13.

Genetics of the serotonergic system in suicidal behavior.

Arango V, Huang YY, Underwood MD, Mann JJ.

J Psychiatr Res. 2003 Sep-Oct;37(5):375-86. Review.

PMID:
12849930
14.

A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism.

Kulikov AV, Osipova DV, Naumenko VS, Terenina E, Mormède P, Popova NK.

Behav Brain Res. 2012 Jul 15;233(1):113-9. doi: 10.1016/j.bbr.2012.04.031. Epub 2012 Apr 26.

PMID:
22561036
15.

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.

Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Sykes CE, Francescutti DM, Kuhn DM.

ACS Chem Neurosci. 2014 Oct 15;5(10):908-19. doi: 10.1021/cn500096g. Epub 2014 Aug 12.

16.

Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect.

Shishkina GT, Kalinina TS, Dygalo NN.

Neuroscience. 2007 Dec 5;150(2):404-12. Epub 2007 Sep 14.

PMID:
17950541
17.

Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis.

Mosienko V, Beis D, Pasqualetti M, Waider J, Matthes S, Qadri F, Bader M, Alenina N.

Behav Brain Res. 2015 Jan 15;277:78-88. doi: 10.1016/j.bbr.2014.06.005. Epub 2014 Jun 11. Review.

PMID:
24928769
18.

Targeting tryptophan hydroxylase 2 in affective disorder.

Popova NK, Kulikov AV.

Expert Opin Ther Targets. 2010 Nov;14(11):1259-71. doi: 10.1517/14728222.2010.524208. Review.

PMID:
20874521
19.

Sex differences in response to chronic mild stress and congenital serotonin deficiency.

Sachs BD, Ni JR, Caron MG.

Psychoneuroendocrinology. 2014 Feb;40:123-9. doi: 10.1016/j.psyneuen.2013.11.008. Epub 2013 Nov 19.

20.

Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice.

Izikki M, Hanoun N, Marcos E, Savale L, Barlier-Mur AM, Saurini F, Eddahibi S, Hamon M, Adnot S.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3.

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